3-(1-Piperazinyl)-1,2-benzisothiazole

Product Name: 3-(1-Piperazinyl)-1,2-benzisothiazole
CAS No.: 87691-87-0
Chemical Name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Synonyms: 3-Piperazinyl-1,2-benzisothiazole (PRB);lurasidone-1;AKOS B030093;3-Piperazinyl-1;Lurasidone INT 2;2-benzisothiazole;Lurasidone Impurity 13;Lurasidone BIP Impurity;Antidepressant agent 10;ASINEX-REAG BAS 13031053
CBNumber: CB3783377
Molecular Formula: C11H13N3S
Formula Weight: 219.31
MOL File: 87691-87-0.mol

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3-(1-Piperazinyl)-1,2-benzisothiazole Property

Melting point:: 89.0 to 93.0 °C
Boiling point:: 320.2±35.0 °C(Predicted)
Density: 1.256
storage temp.: 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 8.52±0.10(Predicted)
color: White to Light yellow
BRN: 4253627
InChI: InChI=1S/C11H13N3S/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14/h1-4,12H,5-8H2
InChIKey: KRDOFMHJLWKXIU-UHFFFAOYSA-N
SMILES: S1C2=C(C=CC=C2)C(N2CCNCC2)=N1
LogP: 2.14
CAS DataBase Reference: 87691-87-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,T
Risk Statements: 25-36/38
Safety Statements: 26-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 728519
Product name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Purity: ≥98% (HPLC)
Packaging: 5g
Price: $140
Updated: 2025/07/31

Sigma-Aldrich

Product number: 728519
Product name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Purity: ≥98% (HPLC)
Packaging: 1g
Price: $57.5
Updated: 2023/06/20

TCI Chemical

Product number: P2064
Product name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $60
Updated: 2025/07/31

TCI Chemical

Product number: P2064
Product name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $176
Updated: 2025/07/31

TRC

Product number: P480600
Product name: 3-(1-Piperazinyl)-1,2-benzisothiazole
Packaging: 25g
Price: $240
Updated: 2021/12/16

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3-(1-Piperazinyl)-1,2-benzisothiazole Chemical Properties,Usage,Production

Chemical Properties

3-(1-Piperazinyl)-1,2-benzisothiazole is Yellow Solid

Uses

3-(1-Piperazinyl)-1,2-benzisothiazole is a reagent used to synthesize Ziprasidione

Definition

ChEBI: ID11614 is a N-arylpiperazine.

IC 50

5-HT_1A Receptor: 190 nM (IC₅₀); 5-HT₂ Receptor: 110 nM (IC₅₀)

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6552 - 6563
[2] Patent: CN108440520, 2018, A. Location in patent: Paragraph 0054; 0056; 0062; 0063
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 3, p. 359 - 369
[4] Patent: WO2010/38948, 2010, A2. Location in patent: Page/Page column 54-55
[5] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2139 - 2151

3-(1-Piperazinyl)-1,2-benzisothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-Piperazinyl)-1,2-benzisothiazole Suppliers

Canada 3 China 356 Europe 1 Germany 2 India 50 Japan 1 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 39 Global 467

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View Lastest Price from 3-(1-Piperazinyl)-1,2-benzisothiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd

Product: 3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1000kg
Release date: 2025-07-11

Jinan Million Pharmaceutical Co., Ltd

Product: 3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price: US $2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1200KG/M
Release date: 2023-08-15

Henan Aochuang Chemical Co.,Ltd.

Product: 3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1ton
Release date: 2022-09-29

87691-87-0, 3-(1-Piperazinyl)-1,2-benzisothiazoleRelated Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Isothiazole 1,2-Benzisothiazol-3(2H)-one 2,2'-Dithiobis(benzothiazole) Probenazole 2-Mercaptobenzothiazole 2-Methyl-4-isothiazolin-3-one Benzothiazole Ziprasidone hydrochloride monohydrate Ziprasidone QT Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One) 3-Oxo Ziprasidone (Ziprasidone Impurity B) Ziprasidone Sulfoxide 5,5'-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6'-dichloro-3-hydroxy-3,3'-biindoline-2,2'-dione Ziprasidone Ring-opened IMpurity (IMpurity C) Ziprasidone Impurity 3 Isopropylidene ziprasidone 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE

Ziprasidone Impurity 6（Ziprasidone EP Impurity A）

lurasidone-1

3-Piperazinyl-1,2-benzisothiazole (PRB)

ASINEX-REAG BAS 13031053

3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE

1,2-BENZISOTHIAZOLE-3-(1-PIPERAZINYL)

1-(1,2-BENZISOTHIAZOL-3-YL)PIPERAZINE

1-(1,2-BENZISOTHIAZOL-3-YL)-PIPERAZINE (BASE)

3-Piperazinyl-1,2-Benzisothiazole Hcl

AKOS B030093

3-PIPERAZIN-1-YL-BENZO[D]ISOTHIAZOLE

3-PIPERAZINYL-1,2-BENZISOTHIAZOLE

3-PIPERAZINOBENZISOTHIAZOLE

4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINE

2-benzisothiazole

3-Piperazinyl-1

BENZTHIAZOLE PIPERAZINE HCL

3-(Piperazin-1-yl)benzoisothiazole

N-(3-Benzisothiazolyl)piperazine

Lurasidone INT 2

3-piperazin-1-yl-1,2-benzothiazole

Ziprasidone EP Impurity A

Lurasidone Impurity 13

3-(1-Piperazinyl)-1,2-benzisothiazole&gt

Lurasidone BIP Impurity

3-(1-PIPERAZINYL)-1 2-BENZISOTHIAZOLE BA SE

3-(1-Piperazinyl)-1,2-benzisothiazole (Lurasidone Impurity)

Ziprasidone EP Impurity A/Ziprasidone RC A

Ziprasidone?EP Impurity A/ Ziprasidone?Related Compound A

3-(1-Piperazinyl)benzisothiazole

3-Piperazin-1-yl-benzo[d]isothiazo

ZiprasidoneEPImpurityA-d8

3-(Piperazin-1-yl)benzo[djisothiazole

Antidepressant agent 10

87691-87-0

876891-87-0

116856-87-0

C11H13N3S

Sulphur Derivatives

API intermediates

Aromatics

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Sulfur & Selenium Compounds

Starting Raw Materials & Intermediates

87691-87-0