ChemicalBook > CAS DataBase List > 3-(1-Piperazinyl)-1,2-benzisothiazole

3-(1-Piperazinyl)-1,2-benzisothiazole

Product Name
3-(1-Piperazinyl)-1,2-benzisothiazole
CAS No.
87691-87-0
Chemical Name
3-(1-Piperazinyl)-1,2-benzisothiazole
Synonyms
3-Piperazinyl-1,2-benzisothiazole (PRB);lurasidone-1;AKOS B030093;3-Piperazinyl-1;Lurasidone INT 2;2-benzisothiazole;Lurasidone Impurity 13;Lurasidone BIP Impurity;Antidepressant agent 10;ASINEX-REAG BAS 13031053
CBNumber
CB3783377
Molecular Formula
C11H13N3S
Formula Weight
219.31
MOL File
87691-87-0.mol
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3-(1-Piperazinyl)-1,2-benzisothiazole Property

Melting point:
89.0 to 93.0 °C
Boiling point:
320.2±35.0 °C(Predicted)
Density 
1.256
storage temp. 
2-8°C
solubility 
soluble in Methanol
form 
powder to crystal
pka
8.52±0.10(Predicted)
color 
White to Light yellow
BRN 
4253627
InChI
InChI=1S/C11H13N3S/c1-2-4-10-9(3-1)11(13-15-10)14-7-5-12-6-8-14/h1-4,12H,5-8H2
InChIKey
KRDOFMHJLWKXIU-UHFFFAOYSA-N
SMILES
S1C2=C(C=CC=C2)C(N2CCNCC2)=N1
LogP
2.14
CAS DataBase Reference
87691-87-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,T
Risk Statements 
25-36/38
Safety Statements 
26-45
RIDADR 
UN 2811 6.1 / PGIII
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29349990
Storage Class
6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects
Hazard Classifications
Acute Tox. 3 Oral
Eye Irrit. 2
Skin Irrit. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
728519
Product name
3-(1-Piperazinyl)-1,2-benzisothiazole
Purity
≥98% (HPLC)
Packaging
5g
Price
$140
Updated
2025/07/31
Sigma-Aldrich
Product number
728519
Product name
3-(1-Piperazinyl)-1,2-benzisothiazole
Purity
≥98% (HPLC)
Packaging
1g
Price
$57.5
Updated
2023/06/20
TCI Chemical
Product number
P2064
Product name
3-(1-Piperazinyl)-1,2-benzisothiazole
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$60
Updated
2025/07/31
TCI Chemical
Product number
P2064
Product name
3-(1-Piperazinyl)-1,2-benzisothiazole
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$176
Updated
2025/07/31
TRC
Product number
P480600
Product name
3-(1-Piperazinyl)-1,2-benzisothiazole
Packaging
10g
Price
$155
Updated
2021/12/16
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3-(1-Piperazinyl)-1,2-benzisothiazole Chemical Properties,Usage,Production

Chemical Properties

3-(1-Piperazinyl)-1,2-benzisothiazole is Yellow Solid

Uses

3-(1-Piperazinyl)-1,2-benzisothiazole is a reagent used to synthesize Ziprasidione

Definition

ChEBI: ID11614 is a N-arylpiperazine.

IC 50

5-HT1A Receptor: 190 nM (IC50); 5-HT2 Receptor: 110 nM (IC50)

References

[1] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 23, p. 6552 - 6563
[2] Patent: CN108440520, 2018, A. Location in patent: Paragraph 0054; 0056; 0062; 0063
[3] Journal of Medicinal Chemistry, 1986, vol. 29, # 3, p. 359 - 369
[4] Patent: WO2010/38948, 2010, A2. Location in patent: Page/Page column 54-55
[5] Chemical and Pharmaceutical Bulletin, 1995, vol. 43, # 12, p. 2139 - 2151

3-(1-Piperazinyl)-1,2-benzisothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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3-(1-Piperazinyl)-1,2-benzisothiazole Suppliers

Canada 3 China 356 Europe 1 Germany 2 India 50 Japan 1 Russia 1 Switzerland 2 The Netherlands 1 Ukraine 1 United Kingdom 10 United States 39 Global 467
Jinan Million Pharmaceutical Co., Ltd
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0531-68659554 13031714605
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3299907431@qq.com
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China
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Shanghai Qiao Chemical Science Co., Ltd
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021-58892003
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info@qiaochem.com
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China
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Jinan Jianfeng Chemical Co., Ltd.
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0531-88110457; 18954159893
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demi@pharmachemm.com
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China
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Shanghai Witofly Chemical Co. ,Ltd.
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02150630626 17717886015
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sales@witofly.com
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Jinan Billion Pharmaceutical Technology Co., Ltd
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+86-15589952515
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80912934@qq.com
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Huaian Jiamu Biotechnology Co., Ltd.
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0517-83187139 18205232085
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cai@jiamu-bio.com
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China
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Anhui Sun-wise Pharmaceutical Co., Ltd.
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18856027890
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055165691851
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sales@sunwisepharm.com
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China
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Suzhou Quanhui Bio-technology Co., ltd
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0512-66368286 18994391916
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fxqhchem@vip.126.com
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China
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J & K SCIENTIFIC LTD.
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18210857532; 18210857532
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86-10-82849933
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jkinfo@jkchemical.com
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China
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Chembest Research Laboratories Limited
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+86-21-20908456
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021-58180499
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sales@BioChemBest.com
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View Lastest Price from 3-(1-Piperazinyl)-1,2-benzisothiazole manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-07-11
Jinan Million Pharmaceutical Co., Ltd
Product
3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price
US $2.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1200KG/M
Release date
2023-08-15
Henan Aochuang Chemical Co.,Ltd.
Product
3-(1-Piperazinyl)-1,2-benzisothiazole 87691-87-0
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1ton
Release date
2022-09-29

87691-87-0, 3-(1-Piperazinyl)-1,2-benzisothiazoleRelated Search:

Methylchloroisothiazolinone/methylisothiazolinone mixture (MCIT/MIT) Isothiazole 1,2-Benzisothiazol-3(2H)-one 2,2'-Dithiobis(benzothiazole) Probenazole 2-Mercaptobenzothiazole 2-Methyl-4-isothiazolin-3-one Benzothiazole Ziprasidone hydrochloride monohydrate Ziprasidone QT Ziprasidone IMpurity (6-Chloro-5-(2-Chloro-1-Hydroxy-Ethyl)-1,3-Dihydro-Indol-2-One) 3-Oxo Ziprasidone (Ziprasidone Impurity B) Ziprasidone Sulfoxide 5,5'-Bis(2-(4-(benzo[d]isothiazol-3-yl)piperazin-1-yl)ethyl)-6,6'-dichloro-3-hydroxy-3,3'-biindoline-2,2'-dione Ziprasidone Ring-opened IMpurity (IMpurity C) Ziprasidone Impurity 3 Isopropylidene ziprasidone 1,1-DIMETHYLETHYL 4-(1,2-BENZISOTHIAZOLE-3-YL)-1-PIPERAZINECARBOXYLATE

  • Ziprasidone Impurity 6（Ziprasidone EP Impurity A）
  • lurasidone-1
  • 3-Piperazinyl-1,2-benzisothiazole (PRB)
  • ASINEX-REAG BAS 13031053
  • 3-(1-PIPERAZINYL)-1,2-BENZISOTHIAZOLE
  • 1,2-BENZISOTHIAZOLE-3-(1-PIPERAZINYL)
  • 1-(1,2-BENZISOTHIAZOL-3-YL)PIPERAZINE
  • 1-(1,2-BENZISOTHIAZOL-3-YL)-PIPERAZINE (BASE)
  • 3-Piperazinyl-1,2-Benzisothiazole Hcl
  • AKOS B030093
  • 3-PIPERAZIN-1-YL-BENZO[D]ISOTHIAZOLE
  • 3-PIPERAZINYL-1,2-BENZISOTHIAZOLE
  • 3-PIPERAZINOBENZISOTHIAZOLE
  • 4-(1,2-BENZISOTHIAZOL-3-YL)-1-PIPERAZINE
  • 2-benzisothiazole
  • 3-Piperazinyl-1
  • BENZTHIAZOLE PIPERAZINE HCL
  • 3-(Piperazin-1-yl)benzoisothiazole
  • N-(3-Benzisothiazolyl)piperazine
  • Lurasidone INT 2
  • 3-piperazin-1-yl-1,2-benzothiazole
  • Ziprasidone EP Impurity A
  • Lurasidone Impurity 13
  • 3-(1-Piperazinyl)-1,2-benzisothiazole&gt
  • Lurasidone BIP Impurity
  • 3-(1-PIPERAZINYL)-1 2-BENZISOTHIAZOLE BA SE
  • 3-(1-Piperazinyl)-1,2-benzisothiazole (Lurasidone Impurity)
  • Ziprasidone EP Impurity A/Ziprasidone RC A
  • Ziprasidone?EP Impurity A/ Ziprasidone?Related Compound A
  • 3-(1-Piperazinyl)benzisothiazole
  • 3-Piperazin-1-yl-benzo[d]isothiazo
  • ZiprasidoneEPImpurityA-d8
  • 3-(Piperazin-1-yl)benzo[djisothiazole
  • Antidepressant agent 10
  • 87691-87-0
  • 876891-87-0
  • 116856-87-0
  • C11H13N3S
  • Sulphur Derivatives
  • API intermediates
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Sulfur & Selenium Compounds
  • Starting Raw Materials & Intermediates
  • 87691-87-0