(+)-EPIBATIDINE DIHYDROCHLORIDE

Product Name: (+)-EPIBATIDINE DIHYDROCHLORIDE
CAS No.: 148152-66-3
Chemical Name: (+)-EPIBATIDINE DIHYDROCHLORIDE
Synonyms: CMI 545;(±)Epibatidine,(±) Epibatidine;(+/-)-EPIBATIDINE HYDROCHLORIDE;(+)-EPIBATIDINE DIHYDROCHLORIDE;2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel-;(+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE;7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO-;EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE;EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE
CBNumber: CB3795844
Molecular Formula: C11H13ClN2
Formula Weight: 208.69
MOL File: 148152-66-3.mol

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(+)-EPIBATIDINE DIHYDROCHLORIDE Property

Boiling point:: 336.7±32.0 °C(Predicted)
Density: 1.223±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: insoluble in H2O; <24.55mg/ml in ethanol
form: solid
pka: 10.07±0.40(Predicted)
color: Off White
Water Solubility: Soluble to 5 mM in water and to 100 mM in ethanol

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: E582200
Product name: (±)-Epibatidine
Packaging: 2.5mg
Price: $195
Updated: 2021/12/16

TRC

Product number: E582200
Product name: (±)-Epibatidine
Packaging: 5mg
Price: $430
Updated: 2021/12/16

TRC

Product number: E582200
Product name: (±)-Epibatidine
Packaging: 25mg
Price: $1540
Updated: 2021/12/16

ApexBio Technology

Product number: B6406
Product name: (±)-Epibatidine
Packaging: 10mg
Price: $448
Updated: 2021/12/16

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(+)-EPIBATIDINE DIHYDROCHLORIDE Chemical Properties,Usage,Production

Uses

(-)-Epibatidine has binding affinities for α4β2 and α3β4 nicotinic receptors.

Definition

ChEBI: 3-(6-chloro-3-pyridinyl)-7-azabicyclo[2.2.1]heptane is an alkaloid.

Biological Activity

(+)-aj 76 hydrochloride is an antagonist of dopamine autoreceptor with pki values of 6.95, 6.67, 6.37, 6.21 and 6.07 for hd3, hd4, hd2s, hd2l and rd2 receptors, respectively.dopamine receptor is a g protein-coupled receptor and mainly exists in the vertebrate central nervous system (cns). dopamine receptor is a receptor for dopamine and plays a critical role in memory, learning, pleasure, cognition, motivation and fine motor control.(+)-aj 76 hydrochloride is a dopamine receptor antagonist. in rats, aj76 stimulated locomotor activity and increased the levels of 3,4-dihydroxyphenylacetic acid (dopac) and hva in brain, which were dopamine metabolites [1]. in rats injected with cocaine, (+)-a j76 increased the locomotor stimulation during the first 30 min. however, (+)-aj76 inhibited the later more intense locomotor stimulation and cocaine-induced stereotypies [2]. in vivo, (+)-aj76 induced dopamine release mainly through interaction with dopamine receptors in the terminal regions of the a9 and a10 dopaminergic fibers. however, (+)-aj76 increased the level of dopac via the somatodendritic autoreceptors [3].

storage

Desiccate at +4°C

References

[1]. kullingsjö h, carlsson a, svensson k. effects of repeated administration of the preferential dopamine autoreceptor antagonist, (+)-aj76, on locomotor activity and brain da metabolism in the rat. eur j pharmacol, 1991, 205(3): 241-246.
[2]. piercey mf, lum jt, hoffmann we, et al. antagonism of cocaine's pharmacological effects by the stimulant dopaminergic antagonists, (+)-aj76 and (+)-uh232. brain res, 1992; 588(2): 217-222.
[3]. waters n, hansson l, löfberg l, et al. intracerebral infusion of (+)-aj76 and (+)-uh232: effects on dopamine release and metabolism in vivo. eur j pharmacol, 1994, 251(2-3): 181-190.

(+)-EPIBATIDINE DIHYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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(+)-EPIBATIDINE DIHYDROCHLORIDE Suppliers

China 7 Germany 1 India 1 Japan 1 Switzerland 1 United Kingdom 1 United States 3 Global 15

3B Pharmachem (Wuhan) International Co.,Ltd.

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Henan Fengda Chemical Co., Ltd

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View Lastest Price from (+)-EPIBATIDINE DIHYDROCHLORIDE manufacturers

Henan Fengda Chemical Co., Ltd

Product: (+)-EPIBATIDINE DIHYDROCHLORIDE 148152-66-3
Price: US $8.00-0.80/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-08

148152-66-3, (+)-EPIBATIDINE DIHYDROCHLORIDERelated Search:

3-[2-(METHYLAMINO)ETHYL]PYRIDINE DIHYDROCHLORIDE 3-Pyridinepropanamine dihydrochloride 7-Azabicyclo[2,2,1]heptane hydrochloride (+/-)-EPIBATIDINE (+)-EPIBATIDINE DIHYDROCHLORIDE (+/-)-EPIBATIDINE DIHYDROCHLORIDE 3-Pyrrolidin-3-yl-pyridinedihydrochloride

(+)-EPIBATIDINE DIHYDROCHLORIDE

(+/-)-EPIBATIDINE HYDROCHLORIDE

EXO-(+)-1R,2R,4S-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE

EXO[+/-]-2-[6-CHLORO-3-PYRIDINYL]-7-AZABICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE

(+/-)-EXO-2-(6-CHLORO-3-PYRIDINYL)-7-AZABICYCLO[2.2.1]HEPTANE HYDROCHLORIDE

2-(6-CHLORO-PYRIDIN-3-YL)-7-AZA-BICYCLO[2.2.1]HEPTANE DIHYDROCHLORIDE

7-AZABICYCLO[2.2.1]HEPTANE, 2-(6-CHLORO-3-PYRIDINYL)-, DIHYDROCHLORIDE, EXO-

CMI 545

7-Azabicyclo[2.2.1]heptane, 2-(6-chloro-3-pyridinyl)-, (1R,2R,4S)-rel-

(±)Epibatidine,(±) Epibatidine

148152-66-3