ChemicalBook > CAS DataBase List > EPAC 5376753
EPAC 5376753
- Product Name
- EPAC 5376753
- CAS No.
- 302826-61-5
- Chemical Name
- EPAC 5376753
- Synonyms
- EPAC 5376753;4,6(1H,5H)-Pyrimidinedione, 5-[[5-(2,4-dichlorophenyl)-2-furanyl]methylene]dihydro-2-thioxo-
- CBNumber
- CB38054392
- Molecular Formula
- C15H8Cl2N2O3S
- Formula Weight
- 367.21
- MOL File
- 302826-61-5.mol
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EPAC 5376753 Property
- Density
- 1.63±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (up to 15 mg/ml) or in DMF (up to 10 mg/ml)
- pka
- 4.86±0.20(Predicted)
- form
- solid
- color
- Orange-red
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or DMF may be stored at -20°C for up to 3 months.
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EPAC 5376753 Chemical Properties,Usage,Production
Description
EPAC 5376753 (302826-61-5) is an allosteric inhibitor of Epac1, IC50= 4 μM.1 Does not inhibit PKA or adenylyl cyclase. Inhibits biological functions mediated by Epac including cAMP-induced increase in migration of cardiac fibroblasts. A useful tool for probing the role of Epac in cellular physiology and pathophysiology.2
References
1) Brown et al. (2014), Allosteric inhibition of Epac: computational modeling and experimental validation to identify allosteric sites and inhibitors; J. Biol. Chem., 289 29148 2) Parnell et al. (2015), The future of EPAC-targeted therapies: agonism versus antagonism; Trends Pharmacol. Sci., 36 203
EPAC 5376753 Preparation Products And Raw materials
Raw materials
Preparation Products
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EPAC 5376753 Suppliers
- Tel
- 010-60605840 15801484223;
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 29774
- Advantage
- 58
- Tel
- 4008200310
- marketing@tsbiochem.com
- Country
- China
- ProdList
- 24647
- Advantage
- 58
- Tel
- 021-65675885 18964387627
- customer_service@efebio.com
- Country
- China
- ProdList
- 11974
- Advantage
- 58
- Tel
- 025-85560043 15850508050
- Fax
- 025-85563444
- cindy.huang@synzest.com
- Country
- China
- ProdList
- 12005
- Advantage
- 58