ASN007
- Product Name
- ASN007
- CAS No.
- 2055597-12-9
- Chemical Name
- ASN007
- Synonyms
- ASN007;ERK-IN-3;ASN007 free base;ASN007（ERAS 007）;ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
- CBNumber
- CB38080025
- Molecular Formula
- C22H25ClFN7O2
- Formula Weight
- 473.93
- MOL File
- 2055597-12-9.mol
ASN007 Property
- Density
- 1.48±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 250 mg/mL (527.50 mM; Need ultrasonic)
- pka
- 12.73±0.46(Predicted)
N-Bromosuccinimide Price
- Product number
- CS-0131841
- Product name
- ERK-IN-3
- Purity
- 98.44%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0131841
- Product name
- ERK-IN-3
- Purity
- 98.44%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0131841
- Product name
- ERK-IN-3
- Purity
- 98.44%
- Packaging
- 25mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0131841
- Product name
- ERK-IN-3
- Purity
- 98.44%
- Packaging
- 50mg
- Price
- $950
- Updated
- 2021/12/16
- Product number
- CS-0131841
- Product name
- ERK-IN-3
- Purity
- 98.44%
- Packaging
- 100mg
- Price
- $1550
- Updated
- 2021/12/16
ASN007 Chemical Properties,Usage,Production
Biological Activity
ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].
References
[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).
ASN007 Preparation Products And Raw materials
Raw materials
Preparation Products
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