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ASN007

Product Name
ASN007
CAS No.
2055597-12-9
Chemical Name
ASN007
Synonyms
ASN007;ERK-IN-3;ASN007 free base;ASN007(ERAS 007);ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
CBNumber
CB38080025
Molecular Formula
C22H25ClFN7O2
Formula Weight
473.93
MOL File
2055597-12-9.mol
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ASN007 Property

Density 
1.48±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO : 250 mg/mL (527.50 mM; Need ultrasonic)
pka
12.73±0.46(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0131841
Product name
ERK-IN-3
Purity
98.44%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0131841
Product name
ERK-IN-3
Purity
98.44%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0131841
Product name
ERK-IN-3
Purity
98.44%
Packaging
25mg
Price
$550
Updated
2021/12/16
ChemScene
Product number
CS-0131841
Product name
ERK-IN-3
Purity
98.44%
Packaging
50mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0131841
Product name
ERK-IN-3
Purity
98.44%
Packaging
100mg
Price
$1550
Updated
2021/12/16
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ASN007 Chemical Properties,Usage,Production

Biological Activity

ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].

References

[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

ASN007 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASN007 Suppliers

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 17702719238
Email
sales@sun-shinechem.com
Country
China
ProdList
918
Advantage
64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3427
Advantage
58
ShangHai Biochempartner Co.,Ltd
Tel
17754423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8011
Advantage
62
Kaixin Chemical (Hong Kong) Limited
Tel
010-88886666-01 13112345678
Fax
CDXH21@126.com
Email
loyson@tcypharm.com
Country
China
ProdList
595
Advantage
55
Amatek Scientific Co. Ltd.
Tel
0512-56316828
Fax
0512-56316826
Email
info@amateksci.com
Country
China
ProdList
28820
Advantage
58
Wuhan Sun-shine Bio-technology Corporation Limited
Tel
+86-027-6552-2453
Email
sales@sun-shinechem.com
Country
China
ProdList
727
Advantage
58
DC Chemicals
Tel
021-58447131 13564518121
Email
sales@dcchemicals.com
Country
China
ProdList
9412
Advantage
58
Chunchuang (Wuhan) Technology Co., Ltd
Tel
15342225168
Email
yutianchun2007@126.com
Country
China
ProdList
10011
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3061
Advantage
58

2055597-12-9, ASN007Related Search:


  • ASN007
  • ASN007 free base
  • N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide
  • ERK-IN-3
  • ASN007(ERAS 007)
  • ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3
  • 1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
  • 2055597-12-9