ASN007

Product Name: ASN007
CAS No.: 2055597-12-9
Chemical Name: ASN007
Synonyms: ASN007;ERK-IN-3;ASN007 free base;ASN007（ERAS 007）;ERK-IN-3, 10 mM in DMSO;ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide;N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide;(S)-N-(2-Amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide;1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-
CBNumber: CB38080025
Molecular Formula: C22H25ClFN7O2
Formula Weight: 473.93
MOL File: 2055597-12-9.mol

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ASN007 Property

Density: 1.48±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 250 mg/mL (527.50 mM; Need ultrasonic)
form: Solid
pka: 12.73±0.46(Predicted)
color: White to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 25mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 50mg
Price: $950
Updated: 2021/12/16

ChemScene

Product number: CS-0131841
Product name: ERK-IN-3
Purity: 98.44%
Packaging: 100mg
Price: $1550
Updated: 2021/12/16

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ASN007 Chemical Properties,Usage,Production

Uses

ASN007 (ERK-IN-3) is a potent and orally active inhibitor of ERK. ASN007 inhibits ERK1/2 with low single-digit nM IC50 values. ASN007 can be used for the research of cancers driven by RAS mutations[1].

Biological Activity

ERK-IN-3 is a potent and orally active inhibitor of ERK. ERK-IN-3 inhibits ERK1/2 with low single-digit nM IC50 values. ERK-IN-3 can be used for the research of cancers driven by RAS mutations[1]. ERK-IN-3 inhibits the phosphorylation of ERK1/2 substrates such as RSK1, FRA1, and Elk1 in various cell lines[1].ERK-IN-3 showes single-digit nanomolar antiproliferative activity that is selective for MAPK-pathway dependent cancer cell lines[1]. ERK-IN-3 (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses[1].

in vivo

ASN007 (ERK-IN-3) (daily p.o.) inhibits tumor growth in multiple BRAF and KRAS mutant xenograft models in mice and was well tolerated at efficacious doses^[1].

IC 50

ERK1; ERK2

References

[1]. Sanjeeva PR, et, al. Abstract B150: ASN007, a novel oral ERK inhibitor, shows robust antitumor activity in RAS mutant cancer models. Molecular Cancer Therapeutics. 2018 Jan; 17(1).

ASN007 Preparation Products And Raw materials

Raw materials

Preparation Products

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ASN007 Suppliers

China 30 United States 2 Global 32

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 18971495150;
Email: sales@sun-shinechem.com
Country: China
ProdList: 1136
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ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 18149758185 18149758185;
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 3505
Advantage: 58

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 7998
Advantage: 62

Kaixin Chemical (Hong Kong) Limited

Tel: 010-88886666-01 13112345678
Fax: CDXH21@126.com
Email: loyson@tcypharm.com
Country: China
ProdList: 597
Advantage: 55

Amatek Scientific Co. Ltd.

Tel: 0512-56316828
Fax: 0512-56316826
Email: info@amateksci.com
Country: China
ProdList: 28774
Advantage: 58

Wuhan Sun-shine Bio-technology Corporation Limited

Tel: +86-027-6552-2453
Email: sales@sun-shinechem.com
Country: China
ProdList: 727
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Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15727060112
Email: yutianchun2007@126.com
Country: China
ProdList: 9835
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Nantong Hi-Future Biotechnology Co., Ltd

Tel: 18051384581
Email: sales@chemhifuture.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
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InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
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2055597-12-9, ASN007Related Search:

ASN007

ASN007 free base

N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-{5-methyl-2-[(oxan-4-yl)amino]pyrimidin-4-yl}-1H-imidazole-4-carboxamide

ERK-IN-3

ASN007（ERAS 007）

ERK1/2,inhibit,ERK,Inhibitor,ERK IN 3,RAS,Extracellular signal regulated kinases,cancer,ERKIN3

1H-Imidazole-4-carboxamide, N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-[(tetrahydro-2H-pyran-4-yl)amino]-4-pyrimidinyl]-

N-[(1S)-2-amino-1-(3-chloro-5-fluorophenyl)ethyl]-1-[5-methyl-2-(oxan-4-ylamino)pyrimidin-4-yl]imidazole-4-carboxamide

(S)-N-(2-Amino-1-(3-chloro-5-fluorophenyl)ethyl)-1-(5-methyl-2-((tetrahydro-2H-pyran-4-yl)amino)pyrimidin-4-yl)-1H-imidazole-4-carboxamide

ERK-IN-3, 10 mM in DMSO

2055597-12-9