ChemicalBook > CAS DataBase List > 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-

Product Name
4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
CAS No.
2360851-29-0
Chemical Name
4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
Synonyms
RBN012759;RBN012759, 10 mM in DMSO;7-(Cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone;7-(Cyclopropylmethoxy)-5-fluoro-2-(((trans-4-hydroxycyclohexyl)thio)methyl)quinazolin-4(1H)-one;4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-;poly ADP ribose polymerase,pro-tumor,cancer,PARP14,PARP,RBN012759,macrophage,RBN 012759,Inhibitor,inflammatory,inhibit,RBN-012759
CBNumber
CB38095876
Molecular Formula
C19H23FN2O3S
Formula Weight
378.46
MOL File
2360851-29-0.mol
More
Less

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Property

storage temp. 
4°C, protect from light
solubility 
DMSO : 250 mg/mL (660.57 mM; Need ultrasonic)
form 
A solid
color 
White to off-white
InChI
InChI=1S/C19H23FN2O3S/c20-15-7-13(25-9-11-1-2-11)8-16-18(15)19(24)22-17(21-16)10-26-14-5-3-12(23)4-6-14/h7-8,11-12,14,23H,1-6,9-10H2,(H,21,22,24)/t12-,14-
InChIKey
NKZDEFKPZSLQRF-MQMHXKEQSA-N
SMILES
N1C2=C(C(F)=CC(OCC3CC3)=C2)C(=O)NC=1CS[C@@H]1CC[C@@H](O)CC1
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0135639
Product name
RBN012759
Purity
99.88%
Packaging
5mg
Price
$400
Updated
2021/12/16
ChemScene
Product number
CS-0135639
Product name
RBN012759
Purity
99.88%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0135639
Product name
RBN012759
Purity
99.88%
Packaging
25mg
Price
$1350
Updated
2021/12/16
ChemScene
Product number
CS-0135639
Product name
RBN012759
Purity
99.88%
Packaging
50mg
Price
$2200
Updated
2021/12/16
ChemScene
Product number
CS-0135639
Product name
RBN012759
Purity
99.88%
Packaging
100mg
Price
$3400
Updated
2021/12/16
More
Less

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Chemical Properties,Usage,Production

Uses

RBN012759 is an inhibitor of PARP14, which is useful in the treatment of cancer and inflammatory diseases.

in vivo

RBN012759 (500 mg/kg BID; p.o.) is well-tolerated in mice with repeat dosing[1].
? RBN012759 (100 mg/kg; p.o.) exhibits moderate orally bioavailability (30%) and short plasma half-life (0.4 h) due to moderate clearance (54 mL/min/kg) and low steady-state volume of distribution (1.4 L/kg) in mice[1].

IC 50

PARP14: <3 nM (IC50); PARP4: 10 μM (IC50); PARP5a: 8 μM (IC50); PARP5b: 10 μM (IC50); PARP6: 4 μM (IC50); PARP7: 4 μM (IC50); PARP8: 20 μM (IC50); PARP10: 1 μM (IC50); PARP11: 1 μM (IC50); PARP12: 5 μM (IC50); PARP15: 3 μM (IC50); PARP16: 6 μM (IC50)

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Suppliers

CHINA 43 United States 4 Global 47
ShangHai ChuanQian Chemcial Technique Centre
Tel
15869524721
Email
3525679403@qq.com
Country
China
ProdList
4989
Advantage
58
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
16075
Advantage
64
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4768
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
ShangHai Biochempartner Co.,Ltd
Tel
177-54423994 17754423994
Fax
QQ:2853530913
Email
2853530910@QQ.com
Country
China
ProdList
8000
Advantage
62
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9125
Advantage
58
Changzhou Chenhong Biotechnology Co., Ltd.
Tel
+86-0519-85788828 +86-13775037613
Email
sales@chemrenpharm.com
Country
China
ProdList
3934
Advantage
58
Suzhou Chenrui Biotechnology Co. LTD
Tel
17625585511
Fax
qq：1580084073
Email
1580084073@qq.com
Country
China
ProdList
961
Advantage
58
cjbscvictory
Tel
13348960310
Email
3003867561@qq.com
Country
China
ProdList
10503
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
2998
Advantage
58
SINO High Goal Chemical Technology Co., Ltd.
Tel
021-57646680 18306277365
Email
guoxin@chembiobanksh.com
Country
China
ProdList
2666
Advantage
58
JinOu Biomedical (Nanjing) Co., Ltd.
Tel
13000000000
Fax
jinoupharma@163
Email
jinoupharma@163.com
Country
China
ProdList
11721
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
59936
Advantage
58
InvivoChem
Tel
13549236410
Email
sales@invivochem.cn
Country
China
ProdList
6753
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24961
Advantage
58
Henan Alpha Chemical Co., Ltd.
Tel
0371-55013243 15324716602
Email
2853979810@qq.com
Country
China
ProdList
9898
Advantage
58
Jiangsu Zhixinting Technology Co., Ltd
Tel
18221391031
Email
1204449826@qq.com
Country
China
ProdList
504
Advantage
58
Suzhou Haiben Pharmaceutical Co., Ltd
Tel
19353112242
Email
1816280386@qq.com
Country
China
ProdList
8045
Advantage
58
Beijing Huiyue Technology Co., Ltd
Tel
17710807091
Email
1210335793@qq.com
Country
China
ProdList
240
Advantage
58
https://hanhongsci.com/
Tel
021-54306202 18917919676
Email
info@hanhongsci.com
Country
China
ProdList
29995
Advantage
58
Hangzhou Bingochem Co., Ltd.
Tel
0571-8512-5372
Email
sales@bingochem.com
Country
China
ProdList
21669
Advantage
58
Nanjing Shizhou Biology Technology Co.,Ltd
Tel
025-85560043 15850508050
Fax
025-85563444
Email
cindy.huang@synzest.com
Country
China
ProdList
12000
Advantage
58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 13167063860
Email
anhua.mao@aladdin-e.com
Country
China
ProdList
48457
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd
Tel
025-58851090 17714375163
Email
2881759498@qq.com
Country
China
ProdList
13011
Advantage
58
Sangon Biotech (Shanghai) Co.,Ltd.
Tel
400-821-026
Email
Sales@sangon.com
Country
China
ProdList
6710
Advantage
58
Cayman Chemical Company
Tel
800-364-9897
Email
sales@caymanchem.com
Country
China
ProdList
6838
Advantage
58
Biosynth Biological Technology (Suzhou) Co Ltd
Tel
51288865780
Email
sales@biosynth.com
Country
China
ProdList
6051
Advantage
58
Selleck Chemicals
Tel
400-668-6834
Email
info@selleck.cn
Country
China
ProdList
6071
Advantage
58
ATK CHEMICAL COMPANY LIMITED
Tel
+undefined-21-51877795
Fax
+86 21 5161 9052/ 5187 7796
Email
ivan@atkchemical.com
Country
China
ProdList
33024
Advantage
60
Chemtour Biotech Co., Ltd
Tel
+8617327281506
Email
market@chemtour.com
Country
China
ProdList
1521
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
HANGZHOU LEAP CHEM CO., LTD.
Tel
+86-571-87711850
Email
market18@leapchem.com
Country
China
ProdList
24727
Advantage
58
Guangzhou Haotian Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
122
Advantage
58
Guangzhou Bingheng Biotechnology Co., Ltd.
Tel
13631342304
Country
CHINA
ProdList
188
Advantage
58
Guangzhou Kangkaixin Biotechnology Co., Ltd.
Tel
13760798286
Country
CHINA
ProdList
188
Advantage
58
Aoki Biotechnology (Shenzhen) Co., Ltd.
Tel
18566777408
Country
CHINA
ProdList
156
Advantage
58
Guangzhou Keyu Biotechnology Co., Ltd.
Tel
18818657868
Country
CHINA
ProdList
0
Advantage
58
Guangzhou Yiran Biotechnology Co., Ltd.
Tel
15571990006
Country
CHINA
ProdList
141
Advantage
58
Biorbyt Ltd.
Tel
--
Fax
--
Email
info@biorbyt.com
Country
CHINA
ProdList
6482
Advantage
58
Neobioscience Co., Ltd.
Tel
--
Fax
--
Email
info@neobioscience.com
Country
CHINA
ProdList
6207
Advantage
58
Absin Bioscience Inc.
Tel
--
Fax
--
Email
chenjw@absin.cn
Country
CHINA
ProdList
6208
Advantage
58
Proteintech China
Tel
--
Fax
--
Email
Proteintech-CN@ptglab.com
Country
CHINA
ProdList
6290
Advantage
58

2360851-29-0, 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-Related Search:


  • 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
  • RBN012759
  • poly ADP ribose polymerase,pro-tumor,cancer,PARP14,PARP,RBN012759,macrophage,RBN 012759,Inhibitor,inflammatory,inhibit,RBN-012759
  • 7-(Cyclopropylmethoxy)-5-fluoro-2-(((trans-4-hydroxycyclohexyl)thio)methyl)quinazolin-4(1H)-one
  • RBN012759, 10 mM in DMSO
  • 7-(Cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone
  • 2360851-29-0