4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-

Product Name: 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
CAS No.: 2360851-29-0
Chemical Name: 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-
Synonyms: RBN012759;RBN012759, 10 mM in DMSO;7-(Cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone;7-(Cyclopropylmethoxy)-5-fluoro-2-(((trans-4-hydroxycyclohexyl)thio)methyl)quinazolin-4(1H)-one;4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-;poly ADP ribose polymerase,pro-tumor,cancer,PARP14,PARP,RBN012759,macrophage,RBN 012759,Inhibitor,inflammatory,inhibit,RBN-012759
CBNumber: CB38095876
Molecular Formula: C19H23FN2O3S
Formula Weight: 378.46
MOL File: 2360851-29-0.mol

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4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Property

storage temp.: 4°C, protect from light
solubility: DMSO : 250 mg/mL (660.57 mM; Need ultrasonic)
form: A solid
color: White to off-white
InChI: InChI=1S/C19H23FN2O3S/c20-15-7-13(25-9-11-1-2-11)8-16-18(15)19(24)22-17(21-16)10-26-14-5-3-12(23)4-6-14/h7-8,11-12,14,23H,1-6,9-10H2,(H,21,22,24)/t12-,14-
InChIKey: NKZDEFKPZSLQRF-MQMHXKEQSA-N
SMILES: N1C2=C(C(F)=CC(OCC3CC3)=C2)C(=O)NC=1CS[C@@H]1CC[C@@H](O)CC1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0135639
Product name: RBN012759
Purity: 99.88%
Packaging: 5mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0135639
Product name: RBN012759
Purity: 99.88%
Packaging: 10mg
Price: $680
Updated: 2021/12/16

ChemScene

Product number: CS-0135639
Product name: RBN012759
Purity: 99.88%
Packaging: 25mg
Price: $1350
Updated: 2021/12/16

ChemScene

Product number: CS-0135639
Product name: RBN012759
Purity: 99.88%
Packaging: 50mg
Price: $2200
Updated: 2021/12/16

ChemScene

Product number: CS-0135639
Product name: RBN012759
Purity: 99.88%
Packaging: 100mg
Price: $3400
Updated: 2021/12/16

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4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Chemical Properties,Usage,Production

Uses

RBN012759 is an inhibitor of PARP14, which is useful in the treatment of cancer and inflammatory diseases.

in vivo

RBN012759 (500 mg/kg BID; p.o.) is well-tolerated in mice with repeat dosing^[1].
? RBN012759 (100 mg/kg; p.o.) exhibits moderate orally bioavailability (30%) and short plasma half-life (0.4 h) due to moderate clearance (54 mL/min/kg) and low steady-state volume of distribution (1.4 L/kg) in mice^[1].

IC 50

PARP14: <3 nM (IC₅₀); PARP4: 10 μM (IC₅₀); PARP5a: 8 μM (IC₅₀); PARP5b: 10 μM (IC₅₀); PARP6: 4 μM (IC₅₀); PARP7: 4 μM (IC₅₀); PARP8: 20 μM (IC₅₀); PARP10: 1 μM (IC₅₀); PARP11: 1 μM (IC₅₀); PARP12: 5 μM (IC₅₀); PARP15: 3 μM (IC₅₀); PARP16: 6 μM (IC₅₀)

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]- Suppliers

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2360851-29-0, 4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-Related Search:

4(3H)-Quinazolinone, 7-(cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-

RBN012759

poly ADP ribose polymerase,pro-tumor,cancer,PARP14,PARP,RBN012759,macrophage,RBN 012759,Inhibitor,inflammatory,inhibit,RBN-012759

7-(Cyclopropylmethoxy)-5-fluoro-2-(((trans-4-hydroxycyclohexyl)thio)methyl)quinazolin-4(1H)-one

RBN012759, 10 mM in DMSO

7-(Cyclopropylmethoxy)-5-fluoro-2-[[(trans-4-hydroxycyclohexyl)thio]methyl]-4(3H)-quinazolinone

2360851-29-0