Pirtobrutinib

Product Name: Pirtobrutinib
CAS No.: 2101700-15-4
Chemical Name: Pirtobrutinib
Synonyms: Pirtobrutinib;Pirtobrutinib (LOXO-305);loxo-305;LY 3527727;BTK inhibitor 16;Florfenicol Impurity 16;LOXO-305，LY 3527727，Pirtobrutinib;(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-;LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation
CBNumber: CB38153637
Molecular Formula: C22H21F4N5O3
Formula Weight: 479.43
MOL File: 2101700-15-4.mol

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Pirtobrutinib Property

Boiling point:: 619.2±55.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 4°C, stored under nitrogen
solubility: DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
form: A solid
pka: 13.32±0.46(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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Pirtobrutinib Chemical Properties,Usage,Production

Description

Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.

Pirtobrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pirtobrutinib Suppliers

China 81 United States 4 Global 85

Chengdu Yunyidian Biological Technology Co.,Ltd

Tel: 17621298782
Email: sales@cdyunyidian.com
Country: China
ProdList: 187
Advantage: 58

ShangHai Caerulum Pharma Discovery Co., Ltd.

Tel: 15000803246 18149758185
Email: sales-cpd@caerulumpharma.com
Country: China
ProdList: 330
Advantage: 58

ChengDu TongChuangYuan Pharmaceutical Co.Ltd

Tel: 028-83379370 13880556291
Fax: 028-87747383
Email: tcy@tcypharm.com
Country: China
ProdList: 6273
Advantage: 58

Chunchuang (Wuhan) Technology Co., Ltd

Tel: 15342225168
Email: yutianchun2007@126.com
Country: China
ProdList: 10003
Advantage: 58

Anqing YanZhi Pharma Discovery Co.,Ltd.

Tel: 18055651951
Email: 2272561977@qq.com
Country: China
ProdList: 426
Advantage: 58

CAREBIO PHARMA

Tel: 18501057619
Email: 771737847@qq.com
Country: China
ProdList: 123
Advantage: 58

Cangzhou Enke Pharma Tech Co.,ltd.

Tel: 0317-5106596 15533709196
Email: 1154424302@qq.com
Country: China
ProdList: 1950
Advantage: 58

Nantong Hanfang Biotechnology Co. , Ltd.

Tel: 18616537568
Email: hanfangpharma@126.com
Country: China
ProdList: 29981
Advantage: 58

WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.

Tel: 17702719238 17702719238
Email: sales@sun-shinechem.com
Country: China
ProdList: 985
Advantage: 64

Shanghai Boc Chemical Co.,Ltd

Tel: 021-34975603-808 18721111801
Fax: +86-21-34975602-805
Email: sales@bocpharma.com
Country: China
ProdList: 998
Advantage: 64

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View Lastest Price from Pirtobrutinib manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Pirtobrutinib 2101700-15-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2024-01-08

2101700-15-4, PirtobrutinibRelated Search:

1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-

(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide

Pirtobrutinib

Pirtobrutinib (LOXO-305)

LY 3527727

loxo-305

(S)-5-Amino-3-{4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-phenyl}-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-pyrazole-4-carboxylic acid amide

LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation

LOXO-305，LY 3527727，Pirtobrutinib

BTK inhibitor 16

Florfenicol Impurity 16

[2,4,6-tribromo-thiophenol, Benzenethiol-2,4,6-tribromide, benzenethiol 2,4,6-tribromine, 2.4.6-Tribrom-phenylmercaptan, 2,4,6-tribromo benzenethiol, 2.4.6-Tribrom-1-mercapto-benzol, 2,4,6-Tribrom-thi

2101700-15-4

api

Pirtobrutinib