Pirtobrutinib

Product Name: Pirtobrutinib
CAS No.: 2101700-15-4
Chemical Name: Pirtobrutinib
Synonyms: Pirtobrutinib;Pirtobrutinib (LOXO-305);loxo-305;LY 3527727;BTK inhibitor 16;Florfenicol Impurity 16;LOXO-305，LY 3527727，Pirtobrutinib;(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide;1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-;LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation
CBNumber: CB38153637
Molecular Formula: C22H21F4N5O3
Formula Weight: 479.43
MOL File: 2101700-15-4.mol

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Pirtobrutinib Property

Boiling point:: 619.2±55.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: 4°C, stored under nitrogen
solubility: DMSO : 50 mg/mL (104.29 mM; Need ultrasonic)
form: A solid
pka: 13.32±0.46(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H360May damage fertility or the unborn child

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P314Get medical advice/attention if you feel unwell.

P501Dispose of contents/container to..…

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Pirtobrutinib Chemical Properties,Usage,Production

Description

Pirtobrutinib, or LOXO-305 and LY 3527727, is a Bruton's tyrosine kinase (BTK) inhibitor and antineoplastic agent. Pirtobrutinib showed promising initial efficacy in pts with pretreated Richter transformation with extremely poor prognosis, including in patients who had received prior chemoimmunotherapy and covalent BTK inhibitors. Pirtobrutinib is a highly selective and potent non-covalent BTK inhibitor (BTKi) with high oral bioavailability and a long half-life, resulting in robust BTK target coverage even in high-grade malignancies with high BTK protein turnover.

Pirtobrutinib Preparation Products And Raw materials

Raw materials

Preparation Products

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Pirtobrutinib Suppliers

China 81 United States 4 Global 85

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

TargetMol Chemicals Inc.

Tel
Email: support@targetmol.com
Country: United States
ProdList: 38631
Advantage: 58

Cayman Chemical Company

Tel: --
Fax: --
Email: cayman@caymanchem.com
Country: United States
ProdList: 6213
Advantage: 81

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View Lastest Price from Pirtobrutinib manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD

Product: Pirtobrutinib 2101700-15-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 200kg
Release date: 2024-01-08

2101700-15-4, PirtobrutinibRelated Search:

1H-Pyrazole-4-carboxamide, 5-amino-3-[4-[[(5-fluoro-2-methoxybenzoyl)amino]methyl]phenyl]-1-[(1S)-2,2,2-trifluoro-1-methylethyl]-

(S)-5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4-carboxamide

Pirtobrutinib

Pirtobrutinib (LOXO-305)

LY 3527727

loxo-305

(S)-5-Amino-3-{4-[(5-fluoro-2-methoxy-benzoylamino)-methyl]-phenyl}-1-(2,2,2-trifluoro-1-methyl-ethyl)-1H-pyrazole-4-carboxylic acid amide

LOXO 305,inhibit,LOXO-305,Btk,Pirtobrutinib,C81S,LOXO305,Bruton tyrosine kinase,proliferative,Inhibitor,mutations,autophosphorylation

LOXO-305，LY 3527727，Pirtobrutinib

BTK inhibitor 16

Florfenicol Impurity 16

[2,4,6-tribromo-thiophenol, Benzenethiol-2,4,6-tribromide, benzenethiol 2,4,6-tribromine, 2.4.6-Tribrom-phenylmercaptan, 2,4,6-tribromo benzenethiol, 2.4.6-Tribrom-1-mercapto-benzol, 2,4,6-Tribrom-thi

2101700-15-4

api

Pirtobrutinib