1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
- Product Name
- 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
- CAS No.
- 210580-75-9
- Chemical Name
- 1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL
- Synonyms
- AL-34662;AL 34497;1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL;1H-Indazol-6-ol, 1-[(2S)-2-aminopropyl]-
- CBNumber
- CB3822775
- Molecular Formula
- C10H13N3O
- Formula Weight
- 191.23
- MOL File
- 210580-75-9.mol
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Property
- Melting point:
- 170-172 °C(Solv: dichloromethane (75-09-2))
- Boiling point:
- 372.8±22.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≤1mg/ml in ethanol;10mg/ml in DMSO;10mg/ml in dimethyl formamide
- form
- crystalline solid
- pka
- 9.30±0.40(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- 10011546
- Product name
- AL 34662
- Purity
- ≥98%
- Packaging
- 1mg
- Price
- $13
- Updated
- 2023/06/20
- Product number
- 10011546
- Product name
- AL 34662
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $51
- Updated
- 2023/06/20
- Product number
- 10011546
- Product name
- AL 34662
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $87
- Updated
- 2023/06/20
- Product number
- 10011546
- Product name
- AL 34662
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $376
- Updated
- 2023/06/20
- Product number
- C5271
- Product name
- AL34662
- Packaging
- 50mg
- Price
- $437
- Updated
- 2021/12/16
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Chemical Properties,Usage,Production
Biological Activity
al 34662 is a potent 5-ht2 receptor agonist.serotonin (5-hydroxytryptamine; 5-ht) is a major neurotransmitter in the central nervous system (cns) of mammals and has welldocumented physiological functions in numerous cells, tissues, and organs.
in vitro
al-34662 exhibited a high affinity for the rat and human 5-ht2 receptor and for cloned human 5-ht2a-c receptors. al-34662 stimulated phosphoinositide turnover in human ciliary muscle and in human trabecular meshwork cells. al-34662 also mobilized intracellular ca2+ in h-cm and h-tm cells, being a full agonist like 5-ht itself. al-34662's effects in the h-cm cells were potently antagonized by 5-ht2a-antagonist m-100907, but weakly by 5-ht2b-antagonist, 5-ht2b/c- antagonist and 5-ht2c antagonist. moreover, it was found that the (r)-enantiomer (al-34707) and the racemate (al-34497) were less potent and/or efficacious than al-34662 in all of these assays [1].
in vivo
al-34662 caused relatively minimal ocular discomfort and hyperemia in rabbit and guinea pig eyes. it efficaciously lowered intraocular pressure in the conscious ocular hypertensive monkey eyes [1].
IC 50
0.8-1.5 nm for rat and human 5-ht2 receptor
References
[1] sharif na, mclaughlin ma, kelly cr. al-34662: a potent, selective, and efficacious ocular hypotensive serotonin-2 receptor agonist. j ocul pharmacol ther. 2007 feb;23(1):1-13.
1-((S)-2-AMINO-PROPYL)-1H-INDAZOL-6-OL Preparation Products And Raw materials
Raw materials
Preparation Products
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