ChemicalBook > CAS DataBase List > 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
- Product Name
- 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
- CAS No.
- 748758-45-4
- Chemical Name
- 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
- Synonyms
- YM 298198 HYDROCHLORIDE;Thiazolo[3,2-a]benzimidazole-2-carboxamide,6-amino-N-cyclohexyl-N,3-dimethyl-;6-amino-N-cyclohexyl-N,3-dimethylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide;6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
- CBNumber
- CB3838194
- Molecular Formula
- C18H22N4OS
- Formula Weight
- 342.46
- MOL File
- 748758-45-4.mol
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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Property
- storage temp.
- Desiccate at +4°C
- Water Solubility
- Soluble in water (100mM)
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N-Bromosuccinimide Price
Tocris
- Product number
- 2448
- Product name
- YM-298198 hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 10
- Price
- $223
- Updated
- 2021/12/16
Tocris
- Product number
- 2448
- Product name
- YM-298198 hydrochloride
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $918
- Updated
- 2021/12/16
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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production
Uses
YM 298198 Hydrochloride is a noncompetitive, high affinity, and selective antagonist of metabotropic glutamate receptor type 1 (mGluR-1).
Definition
ChEBI: 7-amino-N-cyclohexyl-N,1-dimethyl-2-thiazolo[3,2-a]benzimidazolecarboxamide is a member of benzimidazoles.
Biological Activity
Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice.
storage
+4°C (desiccate)
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials
Raw materials
Preparation Products
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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Suppliers
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748758-45-4, 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDERelated Search:
6-AMINO-N-CYCLOHEXYL-3-METHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE