6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE

Product Name: 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
CAS No.: 748758-45-4
Chemical Name: 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
Synonyms: YM 298198 HYDROCHLORIDE;Thiazolo[3,2-a]benzimidazole-2-carboxamide,6-amino-N-cyclohexyl-N,3-dimethyl-;6-amino-N-cyclohexyl-N,3-dimethylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide;6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE
CBNumber: CB3838194
Molecular Formula: C18H22N4OS
Formula Weight: 342.46
MOL File: 748758-45-4.mol

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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Property

storage temp.: Desiccate at +4°C
Water Solubility: Soluble in water (100mM)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 2448
Product name: YM-298198 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 10
Price: $223
Updated: 2021/12/16

Tocris

Product number: 2448
Product name: YM-298198 hydrochloride
Purity: ≥99%(HPLC)
Packaging: 50
Price: $918
Updated: 2021/12/16

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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

YM 298198 Hydrochloride is a noncompetitive, high affinity, and selective antagonist of metabotropic glutamate receptor type 1 (mGluR-1).

Definition

ChEBI: 7-amino-N-cyclohexyl-N,1-dimethyl-2-thiazolo[3,2-a]benzimidazolecarboxamide is a member of benzimidazoles.

Biological Activity

Non-competitive antagonist with high affinity and selectivity for mGlu 1 receptors (K i = 19 nM); inactive at other mGlu receptor subtypes (mGlu 2-7 ), ionotropic receptors and glutamate transporters (IC 50 > 10 μ M). Inhibits glutamate-induced IP production more potently than CPCCOEt (IC 50 values are 16 nM and 6.3 μ M respectively), and is orally active in vivo , demonstrating an antinociceptive effect in hyperalgesic mice.

storage

+4°C (desiccate)

6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE Suppliers

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748758-45-4, 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDERelated Search:

6-AMINO-N-CYCLOHEXYL-3-METHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE 6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE

6-AMINO-N-CYCLOHEXYL-N,3-DIMETHYLTHIAZOLO[3,2-A]BENZIMIDAZOLE-2-CARBOXAMIDE HYDROCHLORIDE

YM 298198 HYDROCHLORIDE

6-amino-N-cyclohexyl-N,3-dimethylbenzo[4,5]imidazo[2,1-b]thiazole-2-carboxamide

Thiazolo[3,2-a]benzimidazole-2-carboxamide,6-amino-N-cyclohexyl-N,3-dimethyl-

748758-45-4

C18H22N4OSHCl

Glutamate receptor

Glutamate