AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

ChemicalBook > CAS DataBase List > AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

Product Name: AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
CAS No.: 106566-58-9
Chemical Name: AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
Synonyms: AS 101;RT-011323;CTK8E8213;Interleukin Related;CTK8E8213;RT-011323;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation
CBNumber: CB3838356
Molecular Formula: C2H4Cl3O2Te.H4N
Formula Weight: 312.049
MOL File: 106566-58-9.mol

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AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Property

storage temp.: Inert atmosphere,Room Temperature
solubility: Soluble in DMSO
form: solid
color: White crystalline

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 21443
Product name: AS-101
Purity: ≥95%
Packaging: 1mg
Price: $32
Updated: 2024/03/01

Cayman Chemical

Product number: 21443
Product name: AS-101
Purity: ≥95%
Packaging: 5mg
Price: $109
Updated: 2024/03/01

Cayman Chemical

Product number: 21443
Product name: AS-101
Purity: ≥95%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Tocris

Product number: 2446
Product name: AS101
Packaging: 50
Price: $616
Updated: 2021/12/16

Tocris

Product number: 2446
Product name: AS101
Packaging: 10
Price: $147
Updated: 2021/12/16

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AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Chemical Properties,Usage,Production

Uses

AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.

Biological Activity

Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.

References

[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.
[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.
[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.
[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.
[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Preparation Products And Raw materials

Raw materials

Preparation Products

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106566-58-9, AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATERelated Search:

TELLURIUM DICHLORIDE AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

AS 101

CTK8E8213

CTK8E8213;RT-011323

RT-011323

Interleukin Related

RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation

AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE

106566-58-9

C2H4Cl3O2TeNH4