AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
- Product Name
- AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
- CAS No.
- 106566-58-9
- Chemical Name
- AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE
- Synonyms
- AS 101;RT-011323;CTK8E8213;Interleukin Related;CTK8E8213;RT-011323;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE;RPE,NFκB,AS 101,Caspase,Inhibitor,inhibit,AS-101,diseases,immunomodulatory,Ossirene,autoimmune,malignancies,tellurium,IL-6,IL-8,p65,Interleukin Related,STAT3,phosphorylation
- CBNumber
- CB3838356
- Molecular Formula
- C2H4Cl3O2Te.H4N
- Formula Weight
- 312.049
- MOL File
- 106566-58-9.mol
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Property
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- Soluble in DMSO
- form
- solid
- color
- White crystalline
N-Bromosuccinimide Price
- Product number
- 21443
- Product name
- AS-101
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 21443
- Product name
- AS-101
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 21443
- Product name
- AS-101
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
- Product number
- 2446
- Product name
- AS101
- Packaging
- 50
- Price
- $616
- Updated
- 2021/12/16
- Product number
- 2446
- Product name
- AS101
- Packaging
- 10
- Price
- $147
- Updated
- 2021/12/16
AMMONIUM TRICHLORO[1,2-ETHANEDIOLATO-O,O']-TELLURATE Chemical Properties,Usage,Production
Uses
AS 101 inhibits AKT activity in leukemic cells and has bee shown to favorably affect renal pathologies in various animal models. AS 101 inhibition of the AKT downstream pathway by AS101 has clinical potential in alleviating the progression of diabetic nephropathy.
Biological Activity
Immunomodulator; inhibits IL-10 synthesis and potentiates IL-1 α , IL-2 and TNF- α release.
References
[1] kalechman y, sredni b, weinstein t, et al. production of the novel mesangial autocrine growth factors gdnf and il-10 is regulated by the immunomodulator as101[j]. journal of the american society of nephrology, 2003, 14(3): 620-630.
[2] kalechman y, gafter u, weinstein t, et al. inhibition of interleukin-10 by the immunomodulator as101 reduces mesangial cell proliferation in experimental mesangioproliferative glomerulonephritis association with dephosphorylation of stat3[j]. journal of biological chemistry, 2004, 279(23): 24724-24732.
[3] sredni b, caspi r r, klein a, et al. a new immunomodulating compound (as-101) with potential therapeutic application[j]. nature, 1987, 330(6144): 173-176.
[4] sredni b, albeck m, tichler t, et al. bone marrow-sparing and prevention of alopecia by as101 in non-small-cell lung cancer patients treated with carboplatin and etoposide[j]. journal of clinical oncology, 1995, 13(9): 2342-2353.
[5] kalechman y, gafter u, gal r, et al. anti-il-10 therapeutic strategy using the immunomodulator as101 in protecting mice from sepsis-induced death: dependence on timing of immunomodulating intervention[j]. the journal of immunology, 2002, 169(1): 384-392.