Niclosamide ethanolamine salt Property

Melting point:

204°

storage temp. 

under inert gas (nitrogen or Argon) at 2–8 °C

solubility 

DMF: 30 mg/mL; DMSO: 30 mg/mL; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/mL; Ethanol: 0.25 mg/mL

form 

A crystalline solid

color 

Light yellow to yellow

Stability:

Stable. Hydrolyzes in concentrated acidic or basic solutions.

CAS DataBase Reference

1420-04-8(CAS DataBase Reference)

EPA Substance Registry System

Clonitralid (1420-04-8)

Safety

RIDADR 

UN2588 (Pesticide, solid, poi- sonous, n.o.s.); UN2902 (Pesticide, liquid, poisonous, n.o.s.)

Hazardous Substances Data

1420-04-8(Hazardous Substances Data)

Toxicity

LD50 oral in rat: 500mg/kg

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Niclosamide ethanolamine salt Chemical Properties,Usage,Production

Chemical Properties

Depending on purity, a bright yellow or brownish-yellow crystalline solid or powder. Odorless. Soluble in water

Uses

The ethanolamine salt as a molluscicide.

General Description

Yellow solid. Insoluble in water.

Air & Water Reactions

Insoluble in water.

Reactivity Profile

Niclosamide ethanolamine salt is hydrolyzed by concentrated acid or alkali.

Fire Hazard

Flash point data for Niclosamide ethanolamine salt are not available. Niclosamide ethanolamine salt is probably combustible.

Agricultural Uses

Molluscicide: Niclosamide, the parent chemical, is a relatively selective, non-cumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of Niclosamide) is used principally against molluscs, especially fresh water snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets and livestock. Niclosamide is toxic to all fish species at 0.5 mg/L (48 hours). A U.S. EPA restricted Use Pesticide as Niclosamide. Limited to use by a certified applicator [40 CFR 152.175 (a) (7/1/94)]. Not listed for use in EU countries. Registered for use in the U.S.

Trade name

BAY 73® and U.S. Fish and Wildlife Service; BAY 6076®; BAYER 73®; BAYER 25648®; BAYLUSCID®[C]; BAYLUSCIDE® and U.S. Fish and Wildlife Service; M 73®; MOLLUSCICIDE BAYER 73®; NICLOSAMIDE®; SR 73®

Potential Exposure

Niclosamide, the parent chemical, is a relatively selective, noncumulative chlorinated aromatic amide pesticide. Clonitralid (ethanolamine salt of niclosamide) is used principally against molluscs, especially fresh water snails and to control sea lamprey larvae and also as an antiparasitic drug in human, pets, and livestock. Niclosamide is toxic to all fish species at 0.5 mg/L (48 hours). A restricted use pesticide in the United States. Limited to use by a certified applicator . Not listed for use in EU countries.

Shipping

UN2588 Pesticides, solid, toxic, Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN2902 Pesticides, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.

Incompatibilities

Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides. Hydrolyzed by strong acids, and alkalies. Slowly hydrolyzes in water, releasing ammonia and forming acetate salts. Decomposes at B200-205°C.

Waste Disposal

Do not discharge into drains or sewers. Containers must be disposed of properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office. Burn in incinerator specifically designed for pesticide disposal or dispose as a hazardous waste in a landfill approved and licensed for the disposal of pesticides. Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Ultimate disposal of the chemical must consider: the material’s impact on air quality; potential migration in soil or water; effects on animal, aquatic, and plant life; and conformance with environmental and public health regulations