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PD 166793

Product Name
PD 166793
CAS No.
199850-67-4
Chemical Name
PD 166793
Synonyms
PD 166793;PD-166793-0000;PD 166793 USP/EP/BP;MMP-2/MMP-3 Inhibitor;N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine;L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-;(S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid;(2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid;(S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
CBNumber
CB3840520
Molecular Formula
C17H18BrNO4S
Formula Weight
412.3
MOL File
199850-67-4.mol
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PD 166793 Property

Melting point:
192-193℃
Density 
1.457
storage temp. 
Sealed in dry,2-8°C
solubility 
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
form 
A crystalline solid
color 
White to pink
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
444284
Product name
MMP-2/MMP-3 Inhibitor III, PD166793 - CAS 199850-67-4 - Calbiochem
Packaging
5mg
Price
$245
Updated
2024/03/01
Cayman Chemical
Product number
23762
Product name
PD 166793
Purity
≥98%
Packaging
5mg
Price
$121
Updated
2024/03/01
Cayman Chemical
Product number
23762
Product name
PD 166793
Purity
≥98%
Packaging
10mg
Price
$171
Updated
2024/03/01
Cayman Chemical
Product number
23762
Product name
PD 166793
Purity
≥98%
Packaging
25mg
Price
$392
Updated
2024/03/01
Tocris
Product number
2520
Product name
PD166793
Purity
≥99%(HPLC)
Packaging
10
Price
$151
Updated
2021/12/16
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PD 166793 Chemical Properties,Usage,Production

Uses

PD 166793 is a matrix metalloproteinase inhibitor in the treatment of inflammatory pathological occurrences involving blood pressure and the cardiac system.

General Description

A cell-permeable biphenylsulfonylvaline compound that acts as a potent inhibitor against MMP-2, -3, and -13 (IC50 = 47, 12, and 8 nM, respectively) and a weaker inhibitor against AMP deaminase (20% inhibition at 0.1 μM), MMP-1, -7, -9, and -14 (IC50 = 6.1, 7.2, 7.9, and 0.24 μM, respectively). Shown to offer therapeutic benefits in vivo in various animal models of heart failure and diabetes.

Biological Activity

Broad spectrum matrix metalloprotease (MMP) inhibitor. Displays high affinity for MMP-2, -3 and -13 (IC 50 values are 4, 7 and 8 nM respectively) and exhibits > 750-fold selectivity over MMP-1, -7 and -9. Attenuates left ventricular remodelling and dysfunction in rat model of heart failure.

Biochem/physiol Actions

Cell permeable: yes

storage

Desiccate at +4°C

PD 166793 Preparation Products And Raw materials

Raw materials

Preparation Products

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PD 166793 Suppliers

China 44 Germany 1 Japan 1 The Netherlands 1 United Kingdom 1 United States 14 Global 62
Axon Medchem BV
Tel
--
Fax
--
Email
info@axonmedchem.com
Country
The Netherlands
ProdList
477
Advantage
30

199850-67-4, PD 166793Related Search:

DECABROMOBIPHENYL 2,2-diphenyl-1-picrylhydrazyl PD 166285 PD173955 PD 0325901 PD 98059 PD184352 PD318088 PD 166793

  • PD 166793
  • (S)-2-(4'-bromobiphenyl-4-ylsulfonamido)-3-methylbutanoic acid
  • N-[(4'-Bromo[1,1'-biphenyl]-4-yl)sulfonyl]-L-valine
  • (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
  • MMP-2/MMP-3 Inhibitor
  • L-Valine, N-[(4'-bromo[1,1'-biphenyl]-4-yl)sulfonyl]-
  • (2S)-2-[[4-(4-bromophenyl)phenyl]sulfonylamino]-3-methylbutanoicaci
  • PD 166793 USP/EP/BP
  • PD-166793-0000
  • (S)-2-(4'-Bromo-[1,1'-biphenyl]-4-ylsulfonamido)-3-methylbutanoic acid
  • 199850-67-4
  • Angiogenesis and Metastasis
  • Protease inhibitor