ChemicalBook > CAS DataBase List > RO 08-2750

RO 08-2750

Product Name
RO 08-2750
CAS No.
37854-59-4
Chemical Name
RO 08-2750
Synonyms
RO 08-2750;Ro 08-2750, 10 mM in DMSO;7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE;7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde;2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde;Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-;growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI
CBNumber
CB3844689
Molecular Formula
C13H10N4O3
Formula Weight
270.24
MOL File
37854-59-4.mol
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RO 08-2750 Property

storage temp. 
Store at -20°C
solubility 
≤2.7mg/ml in DMSO
form 
solid
color 
Orange
InChI
1S/C13H10N4O3/c1-6-3-8-9(4-7(6)5-18)17(2)11-10(14-8)12(19)16-13(20)15-11/h3-5H,1-2H3,(H,16,19,20)
InChIKey
JDEMVNYMYPJJIM-UHFFFAOYSA-N
SMILES
CC1=CC(N=C2C(N3)=O)=C(C=C1C=O)N(C)C2=NC3=O
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Safety

WGK Germany 
WGK 3
Storage Class
11 - Combustible Solids
Hazard Classifications
Muta. 2
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28772
Product name
Ro 08-2750
Packaging
1mg
Price
$37
Updated
2024/03/01
Cayman Chemical
Product number
28772
Product name
Ro 08-2750
Packaging
5mg
Price
$116
Updated
2024/03/01
Cayman Chemical
Product number
28772
Product name
Ro 08-2750
Packaging
10mg
Price
$213
Updated
2024/03/01
Tocris
Product number
2272
Product name
Ro08-2750
Purity
≥95%(HPLC)
Packaging
10
Price
$216
Updated
2021/12/16
Tocris
Product number
2272
Product name
Ro08-2750
Purity
≥95%(HPLC)
Packaging
1
Price
$101
Updated
2021/12/16
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RO 08-2750 Chemical Properties,Usage,Production

Uses

Ro 08-2750 is a TrkA inhibitor and NGF-induced apoptosis inhibitor.

Definition

ChEBI: 7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde is a flavin.

Biological Activity

Non-peptide inhibitor of NGF that binds the NGF dimer (K D ~ 1 μ M) possibly causing a conformational change. Inhibits binding selectively to p75 NTR at submicromolar concentrations and to both p75 NTR and TrkA at higher concentrations (> 5 μ M). Prevents NGF-induced apoptosis in SK-N-MC cells.

in vitro

ro 08-2750 can bind to the ngf dimer with ~ 1:1 binding ratio. binding of ro 08-2750 to ngf induces ngf a concentration-dependent conformational change [1]. binding with low concentration of ro 08-2750, ngf can no longer bind to p75ntr anymore, however, binding to trka is not impaired. at higher concentrations of ro 08-2750 more than 5 mm, the ngf/ro 08-2750 complex can not bind to trka as well. in sk-n-mc cells, ro 08-2750 leads to inhibition of ngf-induced programmed cell death. in pc12 cells, ro 08-2750 can enhance the signal pathway through trka[2].

IC 50

1 μm (binds to ngf) [1]

storage

Store at -20°C

References

[1] arkin mr, wells ja. small-molecule inhibitors of protein-protein interactions: progressing towards the dream. nat rev drug discov. 2004 apr;3(4):301-17.
[2] niederhauser o, mangold m, schubenel r, kusznir ea, schmidt d, hertel c. ngf ligand alters ngf signaling via p75(ntr) and trka. j neurosci res. 2000 aug 1;61(3):263-72.

RO 08-2750 Preparation Products And Raw materials

Raw materials

Preparation Products

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RO 08-2750 Suppliers

China 44 Germany 1 United Kingdom 1 United States 10 Global 56
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
Advantage
58
EMMX Biotechnology LLC
Tel
888-539-0666
Fax
888-539-0666
Email
info@emmx.com
Country
United States
ProdList
8447
Advantage
60
Shanghai Shanyuan pharmaceutical technology co., LTD
Tel
021-31761238 13167072949
Fax
021-31761238
Email
3146446224@qq.com
Country
China
ProdList
1379
Advantage
55
Changzhou PBpharmaceutical R&D Co.,Ltd
Tel
086-0519-83990708 18915800124
Fax
0519-83990708
Email
info@pbpharm.com
Country
China
ProdList
498
Advantage
55
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29662
Advantage
68
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
12306
Advantage
58
Suzhou Nuobeike Biological Technology Co., Ltd.
Tel
13962527677
Fax
-
Email
1551481742@qq.com
Country
China
ProdList
279
Advantage
58
Jinan Yaoyan Pharmaceutical Co., Ltd.
Tel
Fax
-
Email
jnyaoyan@163.com
Country
China
ProdList
3069
Advantage
58
Nanjing Meihao Pharmaceutical Technology Co., Ltd.
Tel
meitaochem@126.com
Email
meitaochem@126.com
Country
China
ProdList
19103
Advantage
58

37854-59-4, RO 08-2750Related Search:

Ethylene glycol G-749 GW441756 LUMIFLAVINE RO 08-2750

  • 2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde
  • 7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE
  • RO 08-2750
  • Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-
  • growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI
  • 7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde
  • Ro 08-2750, 10 mM in DMSO
  • 37854-59-4