RO 08-2750
- Product Name
- RO 08-2750
- CAS No.
- 37854-59-4
- Chemical Name
- RO 08-2750
- Synonyms
- RO 08-2750;7,10-DIMETHYL-2,4-DIOXOBENZO[G]PTERIDINE-8-CARBALDEHYDE;7,10-dimethyl-2,4-dioxo-2,3,4,10-tetrahydrobenzo[g]pteridine-8-carbaldehyde;2,3,4,10-Tetrahydro-7,10-dimethyl-2,4-dioxobenzo[g]pteridine-8-carboxaldehyde;Benzo[g]pteridine-8-carboxaldehyde, 2,3,4,10-tetrahydro-7,10-dimethyl-2,4-dioxo-;growth,MSI,Ro 082750,p75NTR,TRKA,RNA-binding,Nerve,NGF,Inhibitor,leukemia,Apoptosis,AML,Ro 08-2750,inhibit,Ro 08 2750,factor,MUSASHI
- CBNumber
- CB3844689
- Molecular Formula
- C13H10N4O3
- Formula Weight
- 270.24
- MOL File
- 37854-59-4.mol
RO 08-2750 Property
- storage temp.
- Store at -20°C
- solubility
- ≤2.7mg/ml in DMSO
- form
- solid
- color
- Orange
N-Bromosuccinimide Price
- Product number
- 28772
- Product name
- Ro 08-2750
- Packaging
- 1mg
- Price
- $37
- Updated
- 2024/03/01
- Product number
- 28772
- Product name
- Ro 08-2750
- Packaging
- 5mg
- Price
- $116
- Updated
- 2024/03/01
- Product number
- 28772
- Product name
- Ro 08-2750
- Packaging
- 10mg
- Price
- $213
- Updated
- 2024/03/01
- Product number
- 2272
- Product name
- Ro08-2750
- Purity
- ≥95%(HPLC)
- Packaging
- 10
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 2272
- Product name
- Ro08-2750
- Purity
- ≥95%(HPLC)
- Packaging
- 1
- Price
- $101
- Updated
- 2021/12/16
RO 08-2750 Chemical Properties,Usage,Production
Uses
Ro 08-2750 is a TrkA inhibitor and NGF-induced apoptosis inhibitor.
Definition
ChEBI: 7,10-dimethyl-2,4-dioxo-8-benzo[g]pteridinecarboxaldehyde is a flavin.
Biological Activity
Non-peptide inhibitor of NGF that binds the NGF dimer (K D ~ 1 μ M) possibly causing a conformational change. Inhibits binding selectively to p75 NTR at submicromolar concentrations and to both p75 NTR and TrkA at higher concentrations (> 5 μ M). Prevents NGF-induced apoptosis in SK-N-MC cells.
in vitro
ro 08-2750 can bind to the ngf dimer with ~ 1:1 binding ratio. binding of ro 08-2750 to ngf induces ngf a concentration-dependent conformational change [1]. binding with low concentration of ro 08-2750, ngf can no longer bind to p75ntr anymore, however, binding to trka is not impaired. at higher concentrations of ro 08-2750 more than 5 mm, the ngf/ro 08-2750 complex can not bind to trka as well. in sk-n-mc cells, ro 08-2750 leads to inhibition of ngf-induced programmed cell death. in pc12 cells, ro 08-2750 can enhance the signal pathway through trka[2].
IC 50
1 μm (binds to ngf) [1]
storage
Store at -20°C
References
[1] arkin mr, wells ja. small-molecule inhibitors of protein-protein interactions: progressing towards the dream. nat rev drug discov. 2004 apr;3(4):301-17.
[2] niederhauser o, mangold m, schubenel r, kusznir ea, schmidt d, hertel c. ngf ligand alters ngf signaling via p75(ntr) and trka. j neurosci res. 2000 aug 1;61(3):263-72.
RO 08-2750 Preparation Products And Raw materials
Raw materials
Preparation Products
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