3-Chloropropiononitrile
- Product Name
- 3-Chloropropiononitrile
- CAS No.
- 542-76-7
- Chemical Name
- 3-Chloropropiononitrile
- Synonyms
- 3-Chloropropanenitrile;3-CHLOROPROPIONITRILE;CH2ClCH2CN;usafa-8798;USAF a-8798;3-Chlorpropannitril;rcrawastenumberp027;3-choropropionitrile;3-Chloropropuinitrile;3-chloro-propionitril
- CBNumber
- CB3853791
- Molecular Formula
- C3H4ClN
- Formula Weight
- 89.52
- MOL File
- 542-76-7.mol
3-Chloropropiononitrile Property
- Melting point:
- -52--50 °C (lit.)
- Boiling point:
- 174-176 °C (lit.)
- Density
- 1.144 g/mL at 25 °C (lit.)
- refractive index
- n20/D 1.438(lit.)
- Flash point:
- 168 °F
- storage temp.
- Store below +30°C.
- solubility
- 45g/l
- form
- clear liquid
- color
- Colorless to Almost colorless
- Water Solubility
- 4.50 g/100 mL
- Merck
- 14,2160
- BRN
- 1098454
- CAS DataBase Reference
- 542-76-7(CAS DataBase Reference)
- NIST Chemistry Reference
- Cl(CH2)2CN(542-76-7)
- EPA Substance Registry System
- 3-Chloropropionitrile (542-76-7)
Safety
- Hazard Codes
- T+
- Risk Statements
- 23-28
- Safety Statements
- 36/37/39-45
- RIDADR
- UN 3276 6.1/PG 2
- WGK Germany
- 3
- RTECS
- UG1400000
- TSCA
- Yes
- HazardClass
- 6.1
- PackingGroup
- II
- HS Code
- 29269095
- Hazardous Substances Data
- 542-76-7(Hazardous Substances Data)
- Toxicity
- LD50 orally in mice, rats: 9, 100 mg/kg, Fassett in Industrial Hygiene and Toxicology vol. 2, F. A. Patty, Ed. (Interscience, New York, 2nd ed., 1962) pp 2025-2026
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H300Fatal if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C69101
- Product name
- 3-Chloropropionitrile
- Purity
- 98%
- Packaging
- 500g
- Price
- $497
- Updated
- 2023/06/20
- Product number
- C69101
- Product name
- 3-Chloropropionitrile
- Purity
- 98%
- Packaging
- 100g
- Price
- $116
- Updated
- 2023/01/07
- Product number
- C0277
- Product name
- 3-Chloropropionitrile
- Purity
- >98.0%(GC)
- Packaging
- 25mL
- Price
- $36
- Updated
- 2024/03/01
- Product number
- C0277
- Product name
- 3-Chloropropionitrile
- Purity
- >98.0%(GC)
- Packaging
- 500mL
- Price
- $240
- Updated
- 2024/03/01
- Product number
- L05902
- Product name
- 3-Chloropropionitrile, 98%
- Packaging
- 25g
- Price
- $34.65
- Updated
- 2024/03/01
3-Chloropropiononitrile Chemical Properties,Usage,Production
Description
3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor. Molecular weight =89.53;Boiling point=175-176℃ (decomposes); Flashpoint =76℃. Hazard Identification (based on NFPA-704 MRating System): Flammability 2, Reactivity 1
Chemical Properties
3-Chloropropionitrile is a combustible, colorless liquid with an acrid odor
Uses
3-Chloropropionitrile is used in pharmaceutical and polymer synthesis.
Uses
In pharmaceutical and polymer synthesis. Combines the reactivity of a nitrile and an alkyl halide. Because of the cyano group the chlorine atom is more reactive than in ordinary alkyl halides.
Production Methods
3-Chloropropionitrile [542-76-7], 3-chloropropanenitrile, b-chloropropionitrile, ClCH2 CH2CN, Mr 89.53, mp-51℃, bp 175 –176℃ (101.3 kPa), n20D 1.4360, d204 1.1573, is a colorless liquid miscible with acetone, benzene, ethanol and diethyl ether. It can be obtained by hydrochlorination of acrylonitrile with hydrochloric acid [49] and is used as an organic intermediate in the synthesis of the H2-receptor famotidine.
General Description
Colorless liquid with a characteristic acrid odor. Used in pharmaceutical and polymer synthesis.
Reactivity Profile
Toxic gas (hydrogen chloride) is released when the compound is heated above 266 F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat. [EPA, 1998].
Hazard
Toxic by ingestion, inhalation, and skin contact. Combustible.
Health Hazard
Toxic effects are a result of systemic cyanide poisoning. (Non-Specific -- Cyanide) Few poisons are more rapidly lethal. Average oral lethal dose for hydrogen cyanide is approximately 60-90 mg (corresponds to 200 mg of potassium cyanide). Cause of death is lack of oxygen to the body's cells (especially the brain and heart) as a result of the chemical inhibiting cell enzymes.
Fire Hazard
Toxic gas (hydrogen chloride) is released when the compound is heated above 266F. When heated to decomposition, 3-Chloropropiononitrile emits very toxic fumes of chlorine- containing compounds and nitrogen oxides. Avoid heat.
Potential Exposure
This material is used in pharmaceutical manufacture and in polymer synthesis.
First aid
If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifting upper and lower lids. Seek medical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, including resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medical attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.
Use amyl nitrate capsules if symptoms develop. All areaemployees should be trained regularly in emergency measures for cyanide poisoning and in CPR. A cyanide antidotekit should be kept in the immediate work area and must berapidly available. Kit ingredients should be replaced every12 years to ensure freshness. Persons trained in the use ofthis kit, oxygen use, and CPR must be quickly available.
storage
Color Code—Blue: Health Hazard/Poison: Storein a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Before entering confined space where 3-chloropropionitrile may be present, check to make sure that an explosive concentration does not exist. Store in tightly closedcontainers in a cool, well-ventilated area. Metal containersinvolving the transfer of this chemical should be groundedand bonded. Where possible, automatically pump liquidfrom drums or other storage containers to process containers. Drums must be equipped with self-closing valves, pressure vacuum bungs, and flame arresters. Use onlynonsparking tools and equipment, especially when openingand closing containers of this chemical. Sources of ignition,such as smoking and open flames, are prohibited where thischemical is used, handled, or stored in a manner that couldcreate a potential fire or explosion hazard.
Shipping
UN3276 Nitriles, liquid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required, Potential Inhalation Hazard (Special Provision 5).
Incompatibilities
Contact with strong oxidizers may cause a fire and explosion hazard
3-Chloropropiononitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Chloropropiononitrile manufacturers
- Product
- 3-Chloropropiononitrile 542-76-7
- Price
- US $70.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100 tons
- Release date
- 2023-02-20
- Product
- 3-Chloropropiononitrile 542-76-7
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
- Product
- 3-Chloropropiononitrile 542-76-7
- Price
- US $100.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2018-07-31