3-Aminopropionitrile
- Product Name
- 3-Aminopropionitrile
- CAS No.
- 151-18-8
- Chemical Name
- 3-Aminopropionitrile
- Synonyms
- 3-AMINOPROPANENITRILE;BAPN;β-aminopropionitrile;beta-Aminopropionitrile;AMINOPROPIONITRILE;2-CYANOETHYLAMINE;beta-Alaninenitrile;B-AMINOPROPIONITRILE;BETA-AMINOPROPIONONITRILE;e (stabiL
- CBNumber
- CB3853135
- Molecular Formula
- C3H6N2
- Formula Weight
- 70.09
- MOL File
- 151-18-8.mol
3-Aminopropionitrile Property
- Melting point:
- <25 °C
- Boiling point:
- 185 °C
- Density
- 0.9584
- refractive index
- 1.4365-1.4395
- Flash point:
- 79-81°C/16mm
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- Chloroform, Methanol
- form
- Liquid
- pka
- 7.80(at 20℃)
- color
- Clear colorless to yellow
- Water Solubility
- Soluble in water.
- Sensitive
- Air & Moisture Sensitive
- Merck
- 14,469
- BRN
- 1698848
- InChIKey
- AGSPXMVUFBBBMO-UHFFFAOYSA-N
- CAS DataBase Reference
- 151-18-8(CAS DataBase Reference)
- EPA Substance Registry System
- Propanenitrile, 3-amino- (151-18-8)
Safety
- Hazard Codes
- Xn,C
- Risk Statements
- 20/21/22-34-22-63
- Safety Statements
- 36/37-45-36/37/39-26
- RIDADR
- 3276
- RTECS
- UG0350000
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29269090
- Hazardous Substances Data
- 151-18-8(Hazardous Substances Data)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H301Toxic if swalloed
H314Causes severe skin burns and eye damage
H318Causes serious eye damage
H361Suspected of damaging fertility or the unborn child
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P370+P378In case of fire: Use … for extinction.
P403+P235Store in a well-ventilated place. Keep cool.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CDS007521
- Product name
- 3-amino-propionitrile
- Purity
- AldrichCPR
- Packaging
- 1G
- Price
- $201
- Updated
- 2023/06/20
- Product number
- A0408
- Product name
- 3-Aminopropionitrile (stabilized with K2CO3)
- Purity
- >98.0%(GC)(T)
- Packaging
- 25mL
- Price
- $123
- Updated
- 2024/03/01
- Product number
- A13043
- Product name
- 3-Aminopropionitrile, 98%, stab. with potassium carbonate
- Packaging
- 1g
- Price
- $37.65
- Updated
- 2024/03/01
- Product number
- A13043
- Product name
- 3-Aminopropionitrile, 98%, stab. with potassium carbonate
- Packaging
- 5g
- Price
- $102.65
- Updated
- 2024/03/01
- Product number
- A13043
- Product name
- 3-Aminopropionitrile, 98%, stab. with potassium carbonate
- Packaging
- 25g
- Price
- $353.65
- Updated
- 2024/03/01
3-Aminopropionitrile Chemical Properties,Usage,Production
Chemical Properties
clear colourless to yellow liquid. 3-Aminopropionitrile, [151-18-8], 3-aminopropanenitrile, b-aminopropionitrile, H2N – CH2 – CH2CN, Mr 70.09, bp 185℃ (101.3 kPa), n20D 1.4396, is a colorless liquid which tends to slowly polymerize if stored in the presence of air. 3-Aminopropionitrile is prepared by the reaction of acrylonitrile with ammonia and is mainly used as an intermediate in the manufacture of b-alanine and pantothenic acid [48].
Uses
Production of β-alanine and pantothenic acid.
Uses
3-Aminopropionitrile is used for organic synthesis and as pharmaceutical intermediates. As an intermediate used in the manufacture of beta-alanine and pantothenic acid.
Definition
ChEBI: 3-Aminopropionitrile is an aminopropionitrile carrying an amino group at the beta-position. It has a role as a plant metabolite, an antineoplastic agent, an antirheumatic drug and a collagen cross-linking inhibitor. It is a conjugate base of a beta-ammoniopropionitrile.
Safety Profile
Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Nitriles usually have cyanide-like effects. See also CYANIDE. Easily oxidized and unstable. A storage hazard; it polymerizes to an explosive yellow solid. When heated to decomposition it emits toxic fumes of CNand NO,. For fire and explosion hazards see CYANIDE.
Metabolism
3-Aminopropionitrile is the compound present in some Lathyms species (Leguminosae), especially sweet-pea seeds (L. odoratus), causing osteolathyrism in man and animals. Although 3-aminopropionitrile is generally present in the fresh plant as the gama-glutamyl derivative, only the free amine is an effective lathyrogen.
Osteolathyrogens cause skeletal deformations due to interference with the cross-linking between polypeptide chains in the connective tissue components, elastin and collagen. This interference is partly due to inhibition of the synthesis of desmosine and isodesmosine, amino acids which effect the cross-linking in elastin. Cross-linking interference of collagen can be prevented in chicks by feed- ing excess calcium.
It is possible that 3-aminopropionitrile is adegradation product of 3-cyano-alanine, although in many plants the latter compound is converted to asparagine and it has not been detected in Lathyms species.
References
[1] CHAO HAN . Nitrilase-catalyzed hydrolysis of 3-aminopropionitrile at high concentration with a tandem reaction strategy for shifting the reaction to β-alanine formation[J]. Journal of Molecular Catalysis B-enzymatic, 2015, 115: Pages 113-118. DOI:10.1016/j.molcatb.2015.02.007.
[2] C. RICHARD . Rotational spectrum of 3-aminopropionitrile and searches for it in Sagittarius B2(N)[J]. Journal of Molecular Spectroscopy, 2018, 345: Pages 51-59. DOI:10.1016/j.jms.2017.12.003.
[3] MSIEDEEN A A. Conformational Stability of 3-aminopropionitrile: DFT and Ab initio Calculations.[J]. Acta Chimica Slovenica, 2024, 71 2: 244-255. DOI:10.17344/acsi.2023.8486.
[4] A.L.G. ALVES PHD1. Effects of beta-aminopropionitrile fumarate and exercise on equine tendon healing: Gross and histological aspects[J]. Journal of Equine Veterinary Science, 2001, 21 7: Pages 335-340. DOI:10.1016/S0737-0806(01)70076-7.
3-Aminopropionitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Aminopropionitrile manufacturers
- Product
- 3-Aminopropionitrile 151-18-8
- Price
- US $990.00-800.00/ton
- Min. Order
- 1ton
- Purity
- 99%
- Supply Ability
- 5000
- Release date
- 2024-08-19
- Product
- 3-Aminopropionitrile 151-18-8
- Price
- US $5.00-2.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 10000kg
- Release date
- 2024-08-23
- Product
- 3-Aminopropionitrile 151-18-8
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000KG
- Release date
- 2024-07-16