3-Aminopropionitrile Property

Melting point:

<25 °C

Boiling point:

185 °C

Density 

0.9584

refractive index 

1.4365-1.4395

Flash point:

79-81°C/16mm

storage temp. 

Keep in dark place,Inert atmosphere,2-8°C

solubility 

Chloroform, Methanol

form 

Liquid

pka

7.80(at 20℃)

color 

Clear colorless to yellow

Water Solubility 

Soluble in water.

Sensitive 

Air & Moisture Sensitive

Merck 

14,469

BRN 

1698848

InChIKey

AGSPXMVUFBBBMO-UHFFFAOYSA-N

CAS DataBase Reference

151-18-8(CAS DataBase Reference)

EPA Substance Registry System

Propanenitrile, 3-amino- (151-18-8)

Safety

Hazard Codes 

Xn,C

Risk Statements 

20/21/22-34-22-63

Safety Statements 

36/37-45-36/37/39-26

RIDADR 

3276

RTECS 

UG0350000

TSCA 

Yes

HazardClass 

8

PackingGroup 

III

HS Code 

29269090

Hazardous Substances Data

151-18-8(Hazardous Substances Data)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H227Combustible liquid

H301Toxic if swalloed

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P370+P378In case of fire: Use … for extinction.

P403+P235Store in a well-ventilated place. Keep cool.

P405Store locked up.

P501Dispose of contents/container to..…

3-Aminopropionitrile Chemical Properties,Usage,Production

Chemical Properties

clear colourless to yellow liquid. 3-Aminopropionitrile, [151-18-8], 3-aminopropanenitrile, b-aminopropionitrile, H2N – CH2 – CH2CN, Mr 70.09, bp 185℃ (101.3 kPa), n20D 1.4396, is a colorless liquid which tends to slowly polymerize if stored in the presence of air. 3-Aminopropionitrile is prepared by the reaction of acrylonitrile with ammonia and is mainly used as an intermediate in the manufacture of b-alanine and pantothenic acid [48].

Uses

3-Aminopropionitrile is used for organic synthesis and as pharmaceutical intermediates. As an intermediate used in the manufacture of beta-alanine and pantothenic acid.

Uses

Production of β-alanine and pantothenic acid.

Definition

ChEBI: An aminopropionitrile carrying an amino group at the beta-position.

Safety Profile

Moderately toxic by intraperitoneal route. An experimental teratogen. Other experimental reproductive effects. Mutation data reported. Nitriles usually have cyanide-like effects. See also CYANIDE. Easily oxidized and unstable. A storage hazard; it polymerizes to an explosive yellow solid. When heated to decomposition it emits toxic fumes of CNand NO,. For fire and explosion hazards see CYANIDE.

Metabolism

3-Aminopropionitrile is the compound present in some Lathyms species (Leguminosae), especially sweet-pea seeds (L. odoratus), causing osteolathyrism in man and animals. Although 3-aminopropionitrile is generally present in the fresh plant as the gama-glutamyl derivative, only the free amine is an effective lathyrogen.
Osteolathyrogens cause skeletal deformations due to interference with the cross-linking between polypeptide chains in the connective tissue components, elastin and collagen. This interference is partly due to inhibition of the synthesis of desmosine and isodesmosine, amino acids which effect the cross-linking in elastin. Cross-linking interference of collagen can be prevented in chicks by feed- ing excess calcium.
It is possible that 3-aminopropionitrile is adegradation product of 3-cyano-alanine, although in many plants the latter compound is converted to asparagine and it has not been detected in Lathyms species.