11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- Product Name
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- CAS No.
- 111974-74-4
- Chemical Name
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
- Synonyms
- Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QUETIAPINE RC B;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride;Quetiapine Related CoMpound B
- CBNumber
- CB3854879
- Molecular Formula
- C17H18ClN3S
- Formula Weight
- 331.86
- MOL File
- 111974-74-4.mol
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Property
- Melting point:
- 180-184°C
- storage temp.
- Inert atmosphere,2-8°C
- solubility
- Soluble in DMSO, Methanol, Distilled Water
- form
- solid
- color
- Off-white
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
- InChI
- InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
- InChIKey
- MJPARFLICDXWJT-UHFFFAOYSA-N
- SMILES
- C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
- CAS DataBase Reference
- 111974-74-4(CAS DataBase Reference)
Safety
- HS Code
- 2934990002
N-Bromosuccinimide Price
- Product number
- KIT1365
- Product name
- N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol)
- Packaging
- 10x1ml
- Price
- $145
- Updated
- 2021/12/16
- Product number
- D288740
- Product name
- N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride
- Packaging
- 5g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- J11616
- Product name
- QuetiapineEPImpurityB2HCl
- Packaging
- 25mg
- Price
- $39
- Updated
- 2021/12/16
- Product number
- 090783
- Product name
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
- Purity
- 95+%
- Packaging
- 1g
- Price
- $114
- Updated
- 2021/12/16
- Product number
- 090783
- Product name
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $303
- Updated
- 2021/12/16
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Usage,Production
Description
Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4
Chemical Properties
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid
Uses
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic
Uses
N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.
References
1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709
11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers
- Product
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-22
- Product
- 1-Methylindole-3-carboxaldehyde 111974-74-4
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-03-22
- Product
- 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 50000KG/month
- Release date
- 2024-01-31