11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

Product Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
CAS No.: 111974-74-4
Chemical Name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride
Synonyms: Quetiapine EP Impurity B;Norquetiapine dihydrochloride salt;QUETIAPINE RC B;QuetiapineEPImpurityB2HCl;Quetiapine DBTP Metabolite;Quetiapine Impurity-B/RC-2;Quetiapine Impurity B DiHCl;11-(1-Piperazinyl)-dibenzo[b;4]thiazepine dihydrochloride;Quetiapine Related CoMpound B
CBNumber: CB3854879
Molecular Formula: C17H18ClN3S
Formula Weight: 331.86
MOL File: 111974-74-4.mol

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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Property

Melting point:: 180-184°C
storage temp.: Inert atmosphere,2-8°C
solubility: Soluble in DMSO, Methanol, Distilled Water
form: solid
color: Off-white
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO, methanol, or distilled water may be stored at -20°C for up to 3 months.
InChI: InChI=1S/C17H17N3S.ClH/c1-3-7-15-13(5-1)17(20-11-9-18-10-12-20)19-14-6-2-4-8-16(14)21-15;/h1-8,18H,9-12H2;1H
InChIKey: MJPARFLICDXWJT-UHFFFAOYSA-N
SMILES: C1(N2CCNCC2)=NC2C=CC=CC=2SC2=CC=CC=C12.Cl
CAS DataBase Reference: 111974-74-4(CAS DataBase Reference)

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Safety

HS Code: 2934990002

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H413May cause long lasting harmful effects to aquatic life

Precautionary statements

P273Avoid release to the environment.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: KIT1365
Product name: N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride(1.0mg/mLinMethanol)
Packaging: 10x1ml
Price: $145
Updated: 2021/12/16

TRC

Product number: D288740
Product name: N-Des[2-(2-hydroxyethoxy)ethyl]QuetiapineDihydrochloride
Packaging: 5g
Price: $155
Updated: 2021/12/16

AK Scientific

Product number: J11616
Product name: QuetiapineEPImpurityB2HCl
Packaging: 25mg
Price: $39
Updated: 2021/12/16

Matrix Scientific

Product number: 090783
Product name: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepinedihydrochloride
Purity: 95+%
Packaging: 1g
Price: $114
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: APN0000074
Product name: 11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE HYDROCHLORIDE
Purity: 95.00%
Packaging: 1G
Price: $137.55
Updated: 2021/12/16

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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Chemical Properties,Usage,Production

Description

Norquetiapine 2HCl (111974-74-4) is a pharmacologically active metabolite of quetiapine (Seroquel).1? Exhibits distinct pharmacological activity from quetiapine and plays an important role in its antidepressant activity.2? Activates ERK1/2 and induces release of BDNF in C6 glioma cells which may contribute to the antidepressant properties of quetiapine.3?Inhibits the norepinephrine transporter which may contribute to the antipsychotic activity of quetiapine.4

Chemical Properties

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is Pale-Yellow Solid

Uses

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic

Uses

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (Quetiapine EP Impurity B) is a metabolite of Quetiapine, a Benzothiazepine with mixed serotonin and dopamine receptor antagonistic properties used as an antipsychotic.

References

1) Altamura?et al.?(2012),?Effect of quetiapine and norquetiapine on anxiety and depression in major psychoses using a pharmacokinetic approach: a prospective observational study; Clin. Drug Investig.,?32?213 2) Lopez Munoz and Alamo (2013),?Active metabolites as antidepressant drugs: the role of norquetiapine in the mechanism of action of quetiapine in the treatment of mood disorders; Front. Psychiatry,?4?102 3) Di. Benedetto?et al.?(2012),?N-desalkylquetiapine activates ERK1/2 to induce GDNF release in C6 glioma cells: a putative cellular mechanism for quetiapine as antidepressant; Neuropharmacology,?62?209 4) Bjorkholm?et al.?(2013),?Role of concomitant inhibition of the norepinephrine transporter for the antipsychotic effect of quetiapine; Eur. Neuropsychopharmacol.,?23?709

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride Suppliers

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View Lastest Price from 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-22

hebei hongtan Biotechnology Co., Ltd

Product: 1-Methylindole-3-carboxaldehyde 111974-74-4
Price: US $30.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2024-03-22

Hebei Mojin Biotechnology Co., Ltd

Product: 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride 111974-74-4
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2024-01-31

111974-74-4, 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochlorideRelated Search:

Quetiapine Carboxylate Impurity 2-(2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethoxy)ethanol dihydrochloride Quetiapine Dimer Impurity 2-(2-(4-(Dibenzo[b,f][1,4]thiazepin-11-yl)piperazin-1-yl)ethoxy)ethyl Acetate Quetiapine Hydroxy Impurity Quetiapine N-Oxide 1,2-Bis[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethane 10,11-Dihydro-11-oxodibenzo[b,f][1,4]thiazepine Quetiapine IMpurity P (11-(4-Ethylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine fuMarate)) N-(2-((2-(4-(2-(2-Hydroxyethoxy)ethyl)piperazine-1-carbonyl)phenyl)thio)phenyl)acetaMide 2-[2-[2-(4-Dibenzo[b,f][1,4]thiazepin-11-yl-1-piperazinyl)ethoxy]ethoxy]ethanol FuMarate Ethyl Quetiapine Fumarate Salt Quetiapine EP Impurity N DiHCl dibenzo[b,f][1,4]thiazepin-11-amine Quetiapine EP Impurity W Quetiapine Sulfone Quetiapine EP Impurity N Quetiapine EP Impurity C

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine, Dihydrochloride, DBTP,

11-Piperazin-1-yl-dibenzo[B,F][1,4]thiazepine dihydrochloride

Dibenzo[b,f][1,4]thiazepine, 11-(1-piperazinyl)-, hydrochloride (1:2)

11-PIPERAZIONDIBENZO[b,f][1,4]THIAZEPINE DIHYDROCHLORIDE

dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine

dibenzo[b,f][1,4]thiazepine-11-[10H]piperazine dihydrochloride

11-Piperazinodibenzo-[b,f][1,4]-thiazepin

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine 2HCl

Quetiapine IMpurity A (DBTP Metabolite)

Quetiapine DBTP Metabolite

11-PIPERAZYNIL-DIBENZO[B,F][1,4] THIAZEP

Quetiapine EP Impurity B DiHCl

Quetiapine Impurity 28(Quetiapine EP Impurity B)

11-(1-Piperazinyl)-dibenzo[b

4]thiazepine dihydrochloride

Quetiapine Related CoMpound B

11-piperazinyl-dibenzo d,f 1,4 thiazepine dihydrochloride

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride (1.0 Mg/ML in Methanol)

Quetiapine Impurity B DiHCl

Quetiapine EP Impurity B

11-(1-piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-Piperazinodibenzo[b,f][1,4]thiazepine dihydrochloride

11-PIPERAZINYL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-PIPERAZYNIL-DIBENZO[B,F][1,4]THIAZEPINE 2HCl (DBTP)

11-Piperazynil-Dibenzo[b,f][1,4]Thiazepine DIHYDROCHLORIDE

DibenzoB,F1,4Thiazepine-11-Piperazine2Hcl

11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine,2HCl

N-Des[2-(2-hydroxyethoxy)ethyl]Quetiapinedihydrochloride

N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazine2HCl

N-[Dibenzo[b,f][1,4]thiazepine-11-yl]piperazinedihydrochloride

Dibenzo[b,f][1,4] thiazepine-11-amine Hydrochloride

11-Piperazynil-dibenzo (b,f)(1,4)thiazepine-11-piperazine 2HCl

1-(1-PIPERAZINYL)-DIBENZO[B,F][1,4]THIAZEPINEDIHYDROCHLORIDE

11-PIPERAZIN-1-YL-DIBENZO[B,F][1,4]THIAZEPINE 2HCL

11-(Piperazin-1-yl)dibenzo[b,f][1,4

Norquetiapine dihydrochloride

11-Piperazinodibenzo[b,f][1,4]thiazepine DiHCl

Norquetiapine dihydrochloride salt

11-Piperazynil-dibenzo[b,f][1,4]thiazepine dihydrochloride (DBTP)

Quetiapine Impurity-B/RC-2

Quetiapine Fumarate EP Impurity B

Quetiapine EP Impurity B/ Quetiapine Related Compound B (Quetiapine DBTP Metabolite)

11-(piperazine-1-yl)dienzo[b,f][1,4]thiazepine hydrochloride

11- piperazine-dibenzo [b,f][1,4] thiazazine hydrochloride

N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine DihydrochlorideQ: What is N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the CAS Number of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What is the storage condition of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride Q: What are the applications of N-Des[2-(2-hydroxyethoxy)ethyl] Quetiapine Dihydrochloride

111974-74-4 11-(1-Piperazinyl)-dibenzo[b,f][1,4]thiazepine dihydrochloride

11-(piperazin-1-yl)dibenzo[b,f][1,4]thiazepine（Quetiapine EP Impurity B)

Quetiapine Related Compound B (11-(Piperazin-1-yl)dibenzo[b,f][1,4]thiazepine dihydrochloride) (1592737)

Quetiapine Impurity B (EP) DiHCl

Quetiapine Related Compound B as Dihydrochloride

Quetiapine USP Related Compound B as Dihydrochloride

11-(1-piperazinyl)-Dibenzo[b,f][1,4]thiazepine hydrochloride (1:2)

11-Piperazinodibenzo-[b,f][1,4]-thiazepin dihydrochloride

11-piperazine-dibenzo [b,f][1,4] thiazepine dihydrochloride

Quetiapine Fumarate EP Impurity B as Dihydrochloride

QuetiapineEPImpurityB2HCl

Quetiapine EP Impurity B Dihydrochloride