Eletriptan hydrobromide
- Product Name
- Eletriptan hydrobromide
- CAS No.
- 177834-92-3
- Chemical Name
- Eletriptan hydrobromide
- Synonyms
- Relert;Uk 116044-04;Eletriptan HCl;ELETRIPTAN HBR;Eletriptan Base;Unii-m41W832ta3;Eletriptan-d3 HBr;QR-2008082103-ELCPT;etriptan hydrobromide;eletriptan hydrobromide
- CBNumber
- CB3854925
- Molecular Formula
- C22H27BrN2O2S
- Formula Weight
- 463.43
- MOL File
- 177834-92-3.mol
Eletriptan hydrobromide Property
- Melting point:
- 169-171?C
- storage temp.
- Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
- solubility
- DMSO: >10mg/mL
- form
- powder
- color
- off-white to light tan
- InChIKey
- PWVXXGRKLHYWKM-IBGZPJMESA-N
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H318Causes serious eye damage
H412Harmful to aquatic life with long lasting effects
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P273Avoid release to the environment.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- SML3032
- Product name
- Eletriptan hydrobromide
- Purity
- ≥98% (HPLC)
- Packaging
- 10MG
- Price
- $94.2
- Updated
- 2024/03/01
- Product number
- SML3032
- Product name
- Eletriptan hydrobromide
- Purity
- ≥98% (HPLC)
- Packaging
- 50MG
- Price
- $306
- Updated
- 2024/03/01
- Product number
- 1234453
- Product name
- Eletriptan Hydrobromide
- Purity
- United States Pharmacopeia (USP) Reference Standard
- Packaging
- 200MG
- Price
- $715
- Updated
- 2024/03/01
- Product number
- R143400
- Product name
- Relpax
- Packaging
- 25mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- J99624
- Product name
- Eletriptan hydrobromide
- Packaging
- 25mg
- Price
- $221
- Updated
- 2021/12/16
Eletriptan hydrobromide Chemical Properties,Usage,Production
Chemical Properties
Eletriptan hydrobromide is Tan Solid
Originator
Relpax,Pfizer
Uses
Relpax is a second generation triptan drug used in the treatment of migraine headaches.
Uses
antibiotic
Uses
Eletriptan hydrobromide is a second generation triptan drug used in the treatment of migraine headaches.
Definition
ChEBI: Eletriptan hydrobromide is a hydrobromide. It has a role as a serotonergic agonist, a vasoconstrictor agent and a non-steroidal anti-inflammatory drug. It contains an eletriptan(1+).
Manufacturing Process
A mixture of the appropriate phenyl vinyl sulfone, tri-o-tolylphosphine,
palladium (II) acetate, triethlamine and (R)-5-bromo-3-(Nmethylpyrrolidinylmethyl)-1H-indole in anhydrous acetonitrle was heated at
reflux under nitrogen. The resultant reaction mixture was evaporated under
reduced pressure, and the residue was column chromatographed using silica
gel and elution with methylene chloride/absolute ethanol/ammonia to afford
the (R )-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2-ylmethyl)-
1H-indole.
A solution of (R)-5-trans-(2-phenylsulfonylethenyl)-3-(N-methylpyrrolidin-2-
ylmethyl)-1H-indole and 10% Pd/C in ethanolic hydrogen chloride (prepared
from absolute ethanol and acetyl chloride and N,N-dimethylformamide was
shaken under a hydrogen atmosphere at room temperature). The resultant
reaction mixture was filtered through diatomaceous earth (Celite trademark),
washed with absolute ethanol, and the combined filtrates were evaporated
under reduced pressure. The residue was partitioned between ethyl acetate
and water. The organic phase was separated, washed with water, brine, dried(Na2SO4), and evaporated under reduced pressure to afford a oil product.
Column chromatography of this product using silica gel and elution with
methylene chloride/absolute ethanol/ammonia afforded the appropriate (R)-5-
(2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole.
The salt eletriptan hydrobromide may be produced by reaction of the (R)-5-
(2-phenylsulfonylethyl)-3-(N-methylpyrrolidin-2-ylmethyl)-1H-indole with
hydrobromic acid.
brand name
Relpax (Pfizer).
Therapeutic Function
Serotonin agonist
Biological Activity
Orally active, selective 5-HT 1B/1D receptor agonist. Produces a dose-dependent reduction in carotid artery blood flow in vivo . Displays antimigraine activity.
storage
room temperature (desiccate)
Eletriptan hydrobromide Preparation Products And Raw materials
Raw materials
Preparation Products
Eletriptan hydrobromide Suppliers
- Tel
- --
- Fax
- --
- megan.carroll@tevapharm.com
- Country
- Israel
- ProdList
- 296
- Advantage
- 58
View Lastest Price from Eletriptan hydrobromide manufacturers
- Product
- Eletriptan hydrobromide 177834-92-3
- Price
- US $10.00/KG
- Min. Order
- 1g
- Purity
- 99
- Supply Ability
- 2000kg
- Release date
- 2021-08-10
- Product
- Eletriptan hydrobromide 177834-92-3
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 8000 Kilogram/Kilograms per Month
- Release date
- 2019-04-23
- Product
- Eletriptan hydrobromide 177834-92-3
- Price
- US $2.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2018-12-23