1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

ChemicalBook > CAS DataBase List > 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

Synthesis

Product Name: 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
CAS No.: 120014-07-5
Chemical Name: 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
Synonyms: Donepezil-013;Donepezil-013-Z;Dehydro Donepezi;Dehydro Donepezil;Donepezil USP RC A;Donepezil Impurity O;Donepezil Impurity 17;Donepezil related compound;1-Benzyl-4-(5,6-dimethoxy-1-ox;2-[(1-Benzylpiperidin-4-yl)methylen
CBNumber: CB3854945
Molecular Formula: C24H27NO3
Formula Weight: 377.48
MOL File: 120014-07-5.mol

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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Property

Melting point:: 176-178°C
Boiling point:: 542.8±50.0 °C(Predicted)
Density: 1.209±0.06 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
pka: 8.03±0.10(Predicted)

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

AK Scientific

Product number: J11663
Product name: Donepezilrelatedcompound(E/Zmixture)
Packaging: 100mg
Price: $49
Updated: 2021/12/16

Oakwood

Product number: 036506
Product name: 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine
Purity: 97%
Packaging: 1g
Price: $55
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IB18353
Product name: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: IB18353
Product name: 1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine
Packaging: 250mg
Price: $100
Updated: 2021/12/16

Apolloscientific

Product number: OR61173
Product name: 2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one
Purity: 97%
Packaging: 5g
Price: $137
Updated: 2021/12/16

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1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Chemical Properties,Usage,Production

Synthesis

A solution of 5,6-dimethoxy-indanone (19 g, 0.10 mol) in methanol (8 mL) is stirred under inert atmosphere at room temperature. Slowly add NaOH flakes (12.8 g, 0.32 mol) followed by N-benzyl-piperidine-4-carboxaldehyde (20.2 g, 0.10 mol) to the reaction mixture. The mixture was stirred at room temperature for 3 h and progress of the reaction was monitored by TLC (hexane:ethyl acetate; 1:1). Once the reaction is complete, the solid formed was filtered, washed with 5 % acetic acid and then with methanol and dried. The obtained solid (34 g) was taken into a round bottom flask and refluxed with DMF (50 mL). Gradually cooled to room temperature and stirred for 2 h, filtered the solid formed, wash with chilled methanol to afford a pale yellow crystalline solid 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine (32.0 g, 84 %); m.p.: 175-177 °C.

Uses

An impurity of Donepezil; an intermediate as an anti-Alzheimer agent.

Uses

An impurity of Donepezil (D531750); an intermediate as an anti-Alzheimer's agent.

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine manufacturers

Career Henan Chemical Co

Product: 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine 120014-07-5
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10000KGS
Release date: 2020-01-02

120014-07-5, 1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidineRelated Search:

2,6-Dimethoxybenzaldehyde Dimethyldimethoxysilane Diphenyldimethoxysilane Benzyl benzoate Dimethoxymethane Benzyl isocyanate Benzyl chloride N,N-Dimethylbenzylamine Haloperidol 1,1-Dimethoxyethane Benzyl nicotinate Benzyl alcohol Benzyltriethylammonium chloride 5,6-Dimethoxy-1-indanone Donepezil XWAIAVWHZJNZQQ-RPXFAUAJSA-N 5,6-Dimethoxy-2-(pyridine-4-yl)methylene-indan-1-one 5-O-Desmethyl Donepezil

2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one 97%

1-Benzyl-4-(5,6-dimethoxy-1-ox

2-[(E)-(1-BENZYL-4-PIPERIDINYL)METHYLIDENE]-5,6-DIMETHOXY-1-INDANONE

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-

1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine

2-(1-Benzylpiperidin-4-ylmethylidene)-5,6-dimethoxyindan-1-one

2,3-Dihydro-5,6-dimethoxy-2-[[1-(phenylmethyl)-4-piperidinyl]methylene]-1H-inden-1-one

Dehydro Donepezil (Donepezil Impurity)

2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydroinden-1-one

1-Benzyl-4-[(5,6-diMethoxy-1-oxoindan-2-ylidene)Methyl]piperidine (Donepezil IMpurity)

1-Benzyl-4-(5,6-diMethoxy-1-oxoindan-2-ylindeneMet

Dehydro Donepezi

Donepezil USP RC A

1-Benzyl-4-[(1,3-dihydro-5,6-dimethoxy-1-oxo-2H-inden-2-ylidene)methyl]piperidine

2-[(1-Benzylpiperidin-4-yl)methylidene]-2,3-dihydro-5,6-dimethoxy-1H-inden-1-one

Donepezil related coMpound (E/Z Mixture)

1H-Inden-1-one, 2,3-dihydro- 5,6-diMethoxy-2-[[1-( phenylMethyl)-4-piperidinyl] Methylene]-

(E)-2-((1-benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Dehydro Donepezil

Donepezil-013

Donepezil impurity 16/1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

Donepezil related compound

1-benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

2-[(1-benzyl-4-piperidyl)methyleen]-5,6-dimethoxyindan-1-on

2-((1-Benzylpiperidin-4-yl)methylene)-5,6-dimethoxy-2,3-dihydro-1H-inden-1-one

Donepezil Impurity O

Donepezil-013-Z

Donepezil Impurity 17

2-[(1-Benzylpiperidin-4-yl)methylen

1-Benzyl-4-[(5,6-dimethoxy-1-oxoindan-2-ylidene)methyl]piperidine DISCONTINUED. Please see D229775

1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperi...

Donepezil Dehydro Impurity (E/Z mixture)

2-[(1-Benzylpiperidin-4-yl)methylene]-2,3-dihydro-5,6-dimethoxyinden-1-one

(E)-1-Benzyl-4-(5,6-dimethoxy-1-oxoindan-2-ylindenemethyl)piperidine

120014-07-5

C24H27NO3

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