Avasimibe

Product Name: Avasimibe
CAS No.: 166518-60-1
Chemical Name: Avasimibe
Synonyms: CS-90;CI-1011;avasimibe;PD 148515;Ava Maibu;Avasimibe, >=98%;Avasimibe(CI-1011);Avasimibe USP/EP/BP;PD-148515|||CI-1011;Avasimibe Solution, 100ppm
CBNumber: CB3854950
Molecular Formula: C29H43NO4S
Formula Weight: 501.72
MOL File: 166518-60-1.mol

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Avasimibe Property

Melting point:: 178-180° (Lee); mp 169.5-170.4° (Dozeman)
Density: 1.072±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: ≥40mg/mL
form: powder
pka: 1.97±0.70(Predicted)
color: white to tan
InChIKey: PTQXTEKSNBVPQJ-UHFFFAOYSA-N

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Safety

WGK Germany: 3
HS Code: 2935909099

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PZ0190
Product name: Avasimibe
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $129
Updated: 2024/03/01

Sigma-Aldrich

Product number: PZ0190
Product name: Avasimibe
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $309.6
Updated: 2024/03/01

Cayman Chemical

Product number: 18129
Product name: Avasimibe
Purity: ≥98%
Packaging: 5mg
Price: $49
Updated: 2024/03/01

Cayman Chemical

Product number: 18129
Product name: Avasimibe
Purity: ≥98%
Packaging: 10mg
Price: $77
Updated: 2024/03/01

Cayman Chemical

Product number: 18129
Product name: Avasimibe
Purity: ≥98%
Packaging: 25mg
Price: $168
Updated: 2024/03/01

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Avasimibe Chemical Properties,Usage,Production

Uses

Avasimibe has been used as an inhibitor of acyl-coenzyme A: cholesterol acyltransferase (ACAT) in Huh7.5.1 cells for testing its combination with direct-acting antivirals (DAAs) and to test its effect on lipid droplet accumulation in acidosis-adapted cancer cells. It may be used as an inhibitor of ACAT to assess cholesterol esterification in Trypanosoma cruzi.

Uses

Avasimibe is a selective inhibitor of Cholesterol Acyltransferase 1 and CYP2C9. Avasimibe is known to induce apoptosis of glioma cell lines as a model of glioblastoma.

Definition

ChEBI: Avasimibe is a monoterpenoid.

Biological Activity

avasimibe is an orally bioavailable inhibitor of the acyl coenzyme a: cholesterol acyltransferase (acat) with ic50 value of 60nm [1].avasimibe is developed from a strategy to design acat inhibitors with improved bioavailability. it also has solution stability at acidic ph. in the in vitro assay, the ic50 value is dependent on the concentration of microsomes, the amount of membrane available for adsorption as well as the presence of bsa. the treatment of avasimibe during the process of lipid loading causes a concentration-dependent reduction in cellular cholesteryl ester content. this reduction is not accompanied by the accumulation of intracellular free cholesterol, indicating a better safety profile for avasimibe than other acat inhibitors. avasimibe can also reduce the synthesis and secretion of apo b 100 (a component of vldl) in hepg2 cells. in addition, avasimibe can increase the total bile acid synthesis in rat hepatocytes at the concentration of 3μm [1].apart from the antiatherosclerotic efficacy, avasimibe is also found to take participate in the modulation of app trafficking. it can delay and reduce the maturation of app, limiting the availability of app holoprotein for aβ-generatiion [2].

Biochem/physiol Actions

Avasimibe (CI-1011) is an orally bioavailable Acyl-CoA:Cholesterol O-Acyltransferase (ACAT) inhibitor. It was originally developed as an antilepic drug, and was shown to significantly reduce plasma total triglyceride and VLDL-cholesterol, but later clinical trials were disappointing. ACAT has also been investigated as a potential therapeutic target for Alzheimer′s disease. Recent studies have looked at the effects of avasimibe in reducing amyloid pathology by limiting generation and increasing clearance of diffusible amyloid-beta (Abeta).

target

ACAT

storage

Store at +4°C

References

[1] llaverías g, laguna jc, alegret m. pharmacology of the acat inhibitor avasimibe (ci-1011). 2003 spring;21(1):33-50.
[2] huttunen hj, peach c, bhattacharyya r, barren c, pettingell w, hutter-paier b, windisch m, berezovska o, kovacs dm. inhibition of acyl-coenzyme a: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. faseb j. 2009 nov;23(11):3819-28.

Avasimibe Preparation Products And Raw materials

Raw materials

Preparation Products

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Avasimibe Suppliers

Canada 1 China 105 France 1 India 2 United Kingdom 2 United States 17 Global 128

AdooQ BioScience, LLC

Tel: +1 (866) 930-6790
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BOC Sciences

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Target molecule Corp.

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Musechem

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TargetMol Chemicals Inc.

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InvivoChem

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Cckinase, Inc.

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Alchem Pharmtech,Inc.

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Aladdin Scientific

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ApexBio Technology

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Cayman Chemical Company

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United States Biological

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Matrix Scientific

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Santa Cruz Biotechnology, Inc.

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View Lastest Price from Avasimibe manufacturers

Career Henan Chemical Co

Product: Avasimibe 166518-60-1
Price: US $1.00/g
Min. Order: 200KG
Purity: 99%
Supply Ability: 2tons
Release date: 2019-12-19

166518-60-1, AvasimibeRelated Search:

3-Chloropropyltrimethoxysilane N,N-Dimethylacetamide Acetaminophen Sulfuryl chloride Thioacetamide 3-Aminopropyltriethoxysilane Acetamide 2-Cyanoacetamide Trimethoxyphenylsilane N-NITROSODIETHYLAMINE Cumene 2-(4-BIPHENYL)ETHYLAMINE HOMO CUMINIC ALDEHYDE 50 2,4,6-TRIMETHYLPHENETHYLAMINE, 2-MESITYLACETALDEHYDE Avasimibe 2-(2,6-DIMETHYLPHENYL)ACETALDEHYDE

1-[(2,6-DIISOPROPYLPHENOXYSULFONYL)AMINO]-2-(2,4,6-TRIISOPROPYLPHENYL)ETHANONE

Ava Maibu

CS-90

Avasimibe, >=98%

2,6-diisopropylphenyl 2-(2,4,6-triisopropylphenyl)acetylsulfamate

[[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenyl ester] sulfamic acid

PD 148515

avasimibe

n-(2,6-dipropan-2-ylphenoxy)sulfonyl-2-(2,4,6-tripropan-2-ylphenyl)acetamide

N-[(2,6-DIISOPROPYLPHENOXY)SULFONYL]-2-(2,4,6-TRIISOPROPYLPHENYL)ACETAMIDE

((2,4,6-TRIS(1-METHYLETHYL)PHENYL)ACETYL)SULFAMICACID2,6-BIS(1-METHYLETHYL)PHENYLESTER

Avasimibe(CI-1011)

CI-1011

AVASIMIBE;CI-1011; PD 148515

Sulfamic acid,N-[2-[2,4,6-tris(1-methylethyl)phenyl]acetyl]-, 2,6-bis(1-methylethyl)phenylester

Avasimibe Solution, 100ppm

Avasimibe USP/EP/BP

1-({[2,6-bis(propan-2-yl)phenoxy]sulfonyl}amino)-2-[2,4,6-tris(propan-2-yl)phenyl]ethan-1-one

PD-148515|||CI-1011

166518-60-1

C29H43NO4S

Inhibitors