ChemicalBook > CAS DataBase List > Propiverine hydrochloride

Propiverine hydrochloride

Product Name
Propiverine hydrochloride
CAS No.
54556-98-8
Chemical Name
Propiverine hydrochloride
Synonyms
Bup-4;Urecure;Noraguard;Nsc172140;Pollarine;mictonorm;Uronaverine;Mictonetten;PROPIVERINE HCL;Yansuan Bingpaiweilin
CBNumber
CB3855472
Molecular Formula
C23H30ClNO3
Formula Weight
403.94
MOL File
54556-98-8.mol
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Propiverine hydrochloride Property

Melting point:
224-226°C
storage temp. 
2-8°C
solubility 
H2O: soluble5mg/mL, clear (warmed)
form 
powder
color 
white to beige
CAS DataBase Reference
54556-98-8(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
37/38-41
Safety Statements 
26-39
WGK Germany 
3
RTECS 
AH3297000
Toxicity
LD50 in male, female mice, male, female rats (mg/kg): 36, 36, 22, 25 i.v.; 223, 283, 1632, 1411 s.c.; 410, 323, 1000, 1092 orally (Yamashita)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H315Causes skin irritation

H318Causes serious eye damage

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML0602
Product name
Propiverine hydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$37.2
Updated
2024/03/01
Sigma-Aldrich
Product number
SML0602
Product name
Propiverine hydrochloride
Purity
≥98% (HPLC)
Packaging
100mg
Price
$193
Updated
2024/03/01
TRC
Product number
P828000
Product name
Propiverine hydrochloride
Packaging
250mg
Price
$225
Updated
2021/12/16
TRC
Product number
P828000
Product name
Propiverine hydrochloride
Packaging
100mg
Price
$110
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
13193
Product name
PropiverineHCl
Packaging
100mg
Price
$845
Updated
2021/12/16
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Propiverine hydrochloride Chemical Properties,Usage,Production

Description

Propiverine hydrochloride is a new urological agent developed for pollakuria and aconuresis. It appears to exhibit anticholinergic properties and in animal experiments inhibited KCl induced contractions in the bladder and ileum.

Chemical Properties

Off-White Solid

Originator

Apogepha (Germany)

Uses

Propiverine is used in treatment of urinary incontinence. Propiverine is an anticholinergic.

Definition

ChEBI: Propiverine hydrochloride is a diarylmethane.

brand name

Mictonorm; Mictonetten

General Description

Propiverine hydrochloride drug is a tertiary amine with spasmolytic and analgesic properties. This drug exerts neurotropic and musculotropic effects on the urinary bladder and smooth muscles. Propiverine hydrochloride has a half-life of 20 hours.

Biochem/physiol Actions

Propiverine is an antimuscarinic drug used for the treatment of overactive blaqdder and urinary incontinence. Propiverine and/or its metabolites also have calcium channel blocking properties in addition to antimuscarinic activity, which may contribute to the clinical activity.

Clinical Use


Treatment of urinary frequency, urgency and incontinence
Neurogenic bladder instability

Drug interactions

Potentially hazardous interactions with other drugs
Anti-arrhythmics: increased risk of antimuscarinic side effects with disopyramide.

Metabolism

Propiverine is extensively metabolised by intestinal and hepatic enzymes. Four metabolites were identified in urine; two of them are pharmacologically active and may contribute to the therapeutic efficacy.
Propiverine and its metabolites are excreted in the urine, bile and faeces.

Propiverine hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propiverine hydrochloride manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Propiverine hydrochloride 54556-98-8
Price
US $1.00/g
Min. Order
1g
Purity
≥98%
Supply Ability
1kg/month
Release date
2021-06-16
Hebei Weibang Biotechnology Co., Ltd
Product
Propiverine hydrochloride 54556-98-8
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100 mt
Release date
2024-11-20
Baoji Guokang Bio-Technology Co., Ltd.
Product
Propiverine hydrochloride 54556-98-8
Price
US $1142.00/Kg/Bag
Min. Order
100g
Purity
99%
Supply Ability
100kg
Release date
2021-06-04

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