ChemicalBook > CAS DataBase List > Guanfacine

Guanfacine

Product Name: Guanfacine
CAS No.: 29110-47-2
Chemical Name: Guanfacine
Synonyms: C07037;SPD503;SPD 503;SPD-503;Guanfacine;Guanfacine USP/EP/BP;Guanfacine free base;Guanfacine Solution, 100ppm;[(2,6-Dichlorophenyl)acetyl]guanidine;2-(2,6-Dichlorophenylacetyl)guanidine
CBNumber: CB3875216
Molecular Formula: C9H9Cl2N3O
Formula Weight: 246.09
MOL File: 29110-47-2.mol

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Guanfacine Property

Melting point:: 227-230?C
Density: 1.50±0.1 g/cm3(Predicted)
storage temp.: Refrigerator
solubility: Soluble in DMSO
form: Powder
pka: 11.92±0.46(Predicted)
color: White to off-white
BCS Class: 1

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: G816000
Product name: Guanfacine
Packaging: 10mg
Price: $145
Updated: 2021/12/16

Usbiological

Product number: 012992
Product name: Guanfacine
Packaging: 1mg
Price: $566
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0026077
Product name: GUANFACINE
Purity: 95.00%
Packaging: 10MG
Price: $187.95
Updated: 2021/12/16

ApexBio Technology

Product number: B3394
Product name: Guanfacine
Packaging: 50mg
Price: $252
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb611661
Product name: Guanfacine
Packaging: 250mg
Price: $606.9
Updated: 2021/12/16

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Guanfacine Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Estulic,Sandoz,Switz.,1980

Uses

Centrally acting α-adrenoceptor agonist. Antihypertensive.

Uses

Guanfacine centrally acting α-adrenoceptor agonist. Guanfacine is an antihypertensive.

Definition

ChEBI: Guanfacine is a member of acetamides.

Manufacturing Process

2,6-Dichlorophenyl-acetyl-guanidine: A solution of 3.245 g (0.055 mol) of guanidine in isopropanol is added to a solution of 11.7 g (0.05 mol) of 2,6- dichlorophenyl-acetic acid ethyl ester (BP 142°C to 143°C/12 mm of Hg) in 20cc of isopropanol. The reaction mixture is allowed to stand overnight and is subsequently concentrated by evaporation. After recrystallizing the residue from methanol/ether 2,6-dichlorophenyl-acetyl-guanidine is obtained in the form of white grains having a MP of 225°C to 227°C.
2,6-Dichlorophenyl-acetyl-guanidine hydrochloride: A solution of 5.6 g (0.025 mol) of 2,-dichlorophenylacetic acid chloride (BP 137°C to 138°C/12 mm of Hg) in 10 cc of toluene is added dropwise to a mixture of 4.5 g (0.076 mol) of guanidine and 60 cc of toluene. The reaction mixture is allowed to stand at room temperature for 20 minutes, is then heated on a steam bath for 2 hours and is subsequently cooled. The resulting precipitate is filtered off and washed twice with 25 cc amounts of water in order to separate the guanidine hydrochloride. The residue (2,6-dichlorophenyl-acetyl-guanidine) is washed with chloroform for further purification and is then dissolved in 50 cc of isopropanol. The pH-value of the solution is adjusted to 6 with ethanolic hydrochloric acid and the solution is cooled. The resulting white needles are again washed with chloroform. The resulting 2.6-dichlorophenyl-acetylguanidine hydrochloride has a MP of 213°C to 216°C.

brand name

Tenex (Dr. Reddy’s).

Therapeutic Function

Antihypertensive

General Description

Guanfacine is more selective for 2-receptors than isclonidine. Their mechanism of action is the same as that ofclonidine. Differences between clonidine and its twoanalogs are seen in their elimination half-life values and intheir metabolism and urinary excretion patterns. The eliminationhalf-life of clonidine ranges from 20 to 25 hours,whereas that for guanfacine is about 17 hours. Guanabenzhas the shortest DOA of these three agents, with a half-lifeof about 6 hours. Clonidine and guanfacine are excretedunchanged in the urine to the extent of 60% and 50%,respectively. Very little of guanabenz is excreted unchangedin the urine.

Synthesis

Guanfacin, N-amidino-2-(2,6-dichlorophenyl)acetamide (22.3.2), is also synthesized in a very easy synthesis of reacting the acid chloride or ester of 2,6- dichlorophenylacetic acid with guanidine.

Guanfacine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Guanfacine manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: Guanfacine 29110-47-2
Price: US $1.00-4.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 1KG 100K
Release date: 2025-05-19

Shaanxi Dideu New Materials Co. Ltd

Product: Guanfacine 29110-47-2
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 98.0%
Supply Ability: 10000KGS
Release date: 2025-03-28

Shaanxi Dideu Medichem Co. Ltd

Product: Guanfacine 29110-47-2
Price: US $0.00-0.00/Kg
Min. Order: 1KG
Purity: 99.0%
Supply Ability: 500 MT
Release date: 2020-05-09

29110-47-2, GuanfacineRelated Search:

Choline Fenofibrate Propionyl chloride Fluphenazine decanoate Memantine Clonidine Robenidine hydrochloride GUANFACINE HYDROCHLORIDE,GUANFACINE HYDROCHLORIDE SALT,GUANFACINE HCL GUANFACINE HCL USP(CRM STANDARD) Guanfacine-13C, 15N3 2,6-DICHLOROPHENYLACETAMIDE 2,6-DICHLOROPHENETHYLAMINE GUANFACINE HCL,GUANFACINE HYDROCHLORIDE SALT,GUANFACINE HYDROCHLORIDE Guanfacine

Guanfacine

1-(α-Oxo-2,6-dichlorophenethyl)guanidine

2-(2,6-Dichlorophenylacetyl)guanidine

C07037

BenzeneacetaMide, N-(aMinoiMinoMethyl)-2,6-dichloro-

[(2,6-Dichlorophenyl)acetyl]guanidine

N-carbaMiMidoyl-2-(2,6-dichlorophenyl)acetaMide

Guanfacine Solution, 100ppm

N-Amidino-2-[2,6-dichlorophenyl] acetamide

N-(diaminomethylidene)-2-(2,6-dichlorophenyl)acetamide

Guanfacine USP/EP/BP

Guanfacine free base

SPD 503

SPD503

SPD-503

N-Carbamimidoyl-2-(2,6-dichlorophenyl)acetamide , Guanfacine

29110-47-2

C9H9Cl2N3O

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals