tolpropamine hydrochloride
- Product Name
- tolpropamine hydrochloride
- CAS No.
- 3339-11-5
- Chemical Name
- tolpropamine hydrochloride
- Synonyms
- Tolpropamine HCl;Einecs 222-082-9;tolpropamine hydrochloride;tolpropamine hydrochloride USP/EP/BP
- CBNumber
- CB3875256
- Molecular Formula
- C18H23N.ClH
- Formula Weight
- 0
- MOL File
- Mol file
tolpropamine hydrochloride Property
- Melting point:
- 162-164 °C
tolpropamine hydrochloride Chemical Properties,Usage,Production
Originator
Tolpropamine,Hoechst (Aventis)
Manufacturing Process
The Grignard solution (prepared from 53 g bromtoluene and 7.2 g magnesium
in 300 ml of ether) was added dropwise to a solution of 35 g β-
dimethylaminopropiophenone in 50 ml ether. The mixture was refluxed for 3
hours. Then the liquid phase was added to 500 parts of ice and 100 parts
concentrated hydrochloric acid. 1-Phenyl-1-p-tolyl-3-dimethylaminopropanol-1
was crystallized. M.P. of hydrochloride of 1-phenyl-1-p-tolyl-3-
dimethylaminopropanol-1 185°C.
10 g of 1-phenyl-1-p-tolyl-3-dimethylaminopropanol-1 was dissolved in 30 ml
of 85% phosphoric acid and the solution was heated at 130-135°C for 1 hour.
After cooling to the mixture was added a water and an aqueous solution of
sodium hydroxide. γ-Phenyl-γ-p-tolylallyldimethylamine was extracted with
ether and extract was dried with sodium sulfate.
γ-Phenyl-γ-p-tolylallyldimethylamine hydrochloride was hydrogenated with
palladium catalyst. γ-Phenyl-γ-p-tolyl-3-dimethylaminopropan obtained has
melting point 156°C.
Therapeutic Function
Antihistaminic, Antipruritic
tolpropamine hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
tolpropamine hydrochloride Suppliers
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View Lastest Price from tolpropamine hydrochloride manufacturers
- Product
- tolpropamine hydrochloride 3339-11-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-06-17