w-Bromo-4-Hydroxyacetophenone
- Product Name
- w-Bromo-4-Hydroxyacetophenone
- CAS No.
- 53946-87-5
- Chemical Name
- w-Bromo-4-Hydroxyacetophenone
- Synonyms
- w-Bromo-4-Hydroxyacetophenone;2-bromo-4-hydroxypropiophenone;OMEGA-BROMO-4-HYDROXYACETOPHENONE;2-BROMO-4'-HYDROXY PHENYL ACETONE;2-bromo-1-(4-hydroxyphenyl)-1-propanone;2-bromo-(4'-hydroxyphenyl)-propan-1-one;2-Bromo-1-(4-hydroxyphenyl)propan-1-one;1-Propanone, 2-bromo-1-(4-hydroxyphenyl)-
- CBNumber
- CB3875397
- Molecular Formula
- C9H9BrO2
- Formula Weight
- 229.07
- MOL File
- 53946-87-5.mol
w-Bromo-4-Hydroxyacetophenone Property
- Melting point:
- 49-50 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 339.3±17.0 °C(Predicted)
- Density
- 1.532±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 7.74±0.15(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B293385
- Product name
- 2-Bromo-1-(4-hydroxyphenyl)propan-1-one
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 089766
- Product name
- 2-Bromo-1-(4-hydroxyphenyl)propan-1-one
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $189
- Updated
- 2021/12/16
- Product number
- 089766
- Product name
- 2-Bromo-1-(4-hydroxyphenyl)propan-1-one
- Purity
- 95+%
- Packaging
- 1g
- Price
- $420
- Updated
- 2021/12/16
- Product number
- HCH0011241
- Product name
- 2-BROMO-4'-HYDROXYPROPIOPHENONE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503.55
- Updated
- 2021/12/16
- Product number
- 089766
- Product name
- 2-Bromo-1-(4-hydroxyphenyl)propan-1-one
- Purity
- 95+%
- Packaging
- 5g
- Price
- $1183
- Updated
- 2021/12/16
w-Bromo-4-Hydroxyacetophenone Chemical Properties,Usage,Production
Synthesis
70-70-2
53946-87-5
Step 5: 1-(4-hydroxyphenyl)propan-1-one (10.000 g, 66.587 mmol) and pyrrole hydrobromide were dissolved in acetic acid (25 ml) and the reaction mixture was stirred at room temperature for 3 hours and 5 minutes. Subsequently, water (110 ml) was added slowly and dropwise over a period of 20 min and stirring was continued for 30 min before adding water (40 ml). The reaction mixture was cooled to 0°C and allowed to stand at room temperature overnight. A solid precipitated from the reaction mixture and the solid product was collected by filtration, washed with water and dried under vacuum to afford 2-bromo-1-(4-hydroxyphenyl)propan-1-one as a white solid (13.76 g, 90% yield). The product was characterized by 1H-NMR (400 MHz, CDCl3): δ 7.96 (d, 2H), 6.91 (d, 2H), 5.25 (q, 1H), 1.87 (d, 3H). Mass spectrometry analysis showed m/z 229 (M + H)+. Alternative method: 1-(4-hydroxyphenyl)propan-1-one (1 eq.) was dissolved in ethyl acetate (5 vol.) and a mixture of ground CuBr2 (2 eq.) in ethyl acetate (7.5 vol.) was added. The mixture was heated to reflux under vigorous stirring and kept at 60 °C for 4 hours of reaction. Upon completion of the reaction, it was filtered through a filtration aid and the residue was washed with ethyl acetate. The filtrate and washings were combined, treated with activated carbon, filtered again and the solvent evaporated to give the target product.
References
[1] Patent: WO2008/120000, 2008, A1. Location in patent: Page/Page column 34
[2] Patent: WO2015/48507, 2015, A1. Location in patent: Paragraph 0136
[3] Journal of the Chemical Society, 1954, p. 1034,1037
[4] Patent: US4690931, 1987, A
[5] Patent: WO2007/918, 2007, A1. Location in patent: Page/Page column 14-15
w-Bromo-4-Hydroxyacetophenone Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from w-Bromo-4-Hydroxyacetophenone manufacturers
- Product
- w-Bromo-4-Hydroxyacetophenone 53946-87-5
- Price
- US $0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-06-08
- Product
- 2-bromo-1-(4-hydroxyphenyl)propan-1-one 53946-87-5
- Price
- US $9.80/KG
- Min. Order
- 1KG
- Purity
- ≥98%
- Supply Ability
- 20 tons
- Release date
- 2020-01-09