ChemicalBook > CAS DataBase List > 2-Bromo-2′-hydroxyacetophenone

2-Bromo-2′-hydroxyacetophenone

Product Name
2-Bromo-2′-hydroxyacetophenone
CAS No.
2491-36-3
Chemical Name
2-Bromo-2′-hydroxyacetophenone
Synonyms
2-AMINO-3'2-Bromo-2′Cyclohexane Impurity 4;2-HYDROXYPHENACYL BROMIDE;2-BROMO-2'-HYDROXYACETOPHENONE;2-Bromo-2’-hydroxyacetophenone;2-Bromo-2'-hydroxylacetophenone;2-(2-bromoacetyl)hydroxybenzene;2-Bromo-2'-hydroxyacetophenone 97%;2-Bromo-2'-hydroxyacetophenone ,97%
CBNumber
CB6675345
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
2491-36-3.mol
More
Less

2-Bromo-2′-hydroxyacetophenone Property

Melting point:
44-48 °C(lit.)
Boiling point:
152-158 °C(Press: 18 Torr)
Density 
1.622±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform, Methanol
pka
7.63±0.30(Predicted)
form 
Solid
color 
Yellow
Sensitive 
Lachrymatory
CAS DataBase Reference
2491-36-3(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
C
Risk Statements 
22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
RTECS 
KM5556400
Hazard Note 
Corrosive/Lachrymatory/Keep Cold
HazardClass 
8
PackingGroup 
II
HS Code 
29147000
Toxicity
mouse,LD50,oral,821mg/kg (821mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 183, 1992.
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
594938
Product name
2-Bromo-2′-hydroxyacetophenone
Purity
97%
Packaging
1g
Price
$70.5
Updated
2022/05/15
Sigma-Aldrich
Product number
594938
Product name
2-Bromo-2′-hydroxyacetophenone
Purity
97%
Packaging
5g
Price
$137
Updated
2022/05/15
TCI Chemical
Product number
B4735
Product name
2-Bromo-2'-hydroxyacetophenone
Packaging
1G
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
B4735
Product name
2-Bromo-2'-hydroxyacetophenone
Packaging
5G
Price
$225
Updated
2025/07/31
TRC
Product number
B684455
Product name
2-Bromo-2’-hydroxyacetophenone
Packaging
1g
Price
$205
Updated
2021/12/16
More
Less

2-Bromo-2′-hydroxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

2-Bromo-2′-hydroxyacetophenone is used as a pharmaceutical intermediate.

Synthesis

118-93-4

2491-36-3

The general procedure for the synthesis of 2-bromo-1-(2-hydroxyphenyl)ethanone from 2'-hydroxyacetophenone is as follows: in a 50 mL round-bottomed flask equipped with a magnetic stirrer, 2'-hydroxyacetophenone (10 mmol) was added. Subsequently, potassium bromide (40 mmol) dissolved in 20 mL of water was added to this solution and mixed with stirring at room temperature. Next, 30% hydrogen peroxide (4 mmol) was slowly added. Vanadium (V) complex (0.01 mmol) and 70% perchloric acid (4 mmol) were further added to the reaction system, and the reaction mixture was stirred at 0°C, followed by raising to room temperature and continued stirring for 10 minutes. Under continuous stirring conditions, additional 70% perchloric acid (4 mmol) was added every 10 min for three times. The reaction process was monitored by thin layer chromatography (TLC). The nuclear magnetic resonance (NMR) spectral data of the final brominated product is detailed in the Supporting Information.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[2] Tetrahedron, 2001, vol. 57, # 11, p. 2203 - 2211
[3] Archiv der Pharmazie, 2009, vol. 342, # 9, p. 541 - 545
[4] Synthetic Communications, 2006, vol. 36, # 19, p. 2877 - 2881
[5] Journal of Organometallic Chemistry, 2018, vol. 876, p. 10 - 16

2-Bromo-2′-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Bromine Acetic acid 2'-Hydroxyacetophenone

Preparation Products

More
Less

2-Bromo-2′-hydroxyacetophenone Suppliers

Australia 1 Canada 2 China 100 Europe 2 France 1 Germany 3 India 8 Switzerland 3 United Kingdom 9 United States 24 Global 153
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801 18930552037
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15838
Advantage
69
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44801
Advantage
61
Beijing Ouhe Technology Co., Ltd
Tel
010-010-82967028 13522913783
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12000
Advantage
60
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
15883
Advantage
64
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42934
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Shanghai Sunway Pharmaceutical Technology Co., Ltd
Tel
18270980682
Fax
021 51613951
Email
mlcheng@sunwaypharm.cn
Country
China
ProdList
8669
Advantage
57
More
Less

View Lastest Price from 2-Bromo-2′-hydroxyacetophenone manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-2′-hydroxyacetophenone 2491-36-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-23
Henan Aochuang Chemical Co.,Ltd.
Product
2-BROMO-2'-HYDROXYACETOPHENONE 2491-36-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

2491-36-3, 2-Bromo-2′-hydroxyacetophenoneRelated Search:

3-BROMOCHROMONE 2-BROMO-2'-METHOXYACETOPHENONE 2-BROMO-2',5'-DIMETHOXYACETOPHENONE 2-Bromo-2′,4′-dimethoxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,2-Bromo-4-Hydroxyacetophenone98%,α-Bromo-4-hydroxyacetophenone 5-Bromo-2-hydroxyacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 3',5'-Dibromo-4'-hydroxyacetophenone 4'-BROMO-2-HYDROXYACETOPHENONE 3',5'-Dibromo-2'-hydroxyacetophenone 4-BROMO-2-HYDROXYACETOPHENONE,4-Bromo-2-hydroxyacetophenone ,97% 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone 2-BROMO-2'-HYDROXYACETOPHENONE OXIME 2-Bromo-3'-hydroxyacetophenone 3'-BROMO-4'-HYDROXYACETOPHENONE 2,3-DIBROMO-1-(5-CHLORO-2-HYDROXYPHENYL)-3-PHENYLPROPAN-1-ONE 2-BROMO-2,3-DIHYDRO-4,7-DIMETHOXY-1H-INDEN-1-ONE

  • 2-Bromo-2'-hydroxyacetophenone ,97%
  • 2-Bromo-2'-hydroxyacetophenone, 2-Bromo-1-(2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)phenol
  • 2-broMo-1-(2-hydroxyphenyl)ethan-1-one
  • 2-Bromo-2'-hydroxyacetophenone 97%
  • JR-8498, 2-Bromo-1-(2-hydroxyphenyl)ethanone, 97%
  • 2-bromo-1-(2-hydroxyphenyl)-ethanon
  • 2-HYDROXYPHENACYL BROMIDE
  • 2-BROMO-1-(2-HYDROXYPHENYL)ETHANONE
  • 2-BROMO-2'-HYDROXYACETOPHENONE
  • 2-Bromo-2'-hydroxylacetophenone
  • Ethanone, 2-bromo-1-(2-hydroxyphenyl)-
  • 2-(2-bromoacetyl)hydroxybenzene
  • 2-AMINO-3&#39
  • 2-Bromo-2’-hydroxyacetophenone
  • 2-Bromo-2&#8242
  • Cyclohexane Impurity 4
  • 2491-36-3
  • BrCH2COC6H4OH
  • Organic Building Blocks
  • Ketones
  • Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Intermediate of Neticonazole Hydrochloride
  • API intermediates
  • Aromatics
  • C7 to C8
  • Carbonyl Compounds
  • Ketones