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2-Bromo-2′-hydroxyacetophenone

Product Name
2-Bromo-2′-hydroxyacetophenone
CAS No.
2491-36-3
Chemical Name
2-Bromo-2′-hydroxyacetophenone
Synonyms
2-AMINO-3'2-Bromo-2′Cyclohexane Impurity 4;2-HYDROXYPHENACYL BROMIDE;2-BROMO-2'-HYDROXYACETOPHENONE;2-Bromo-2’-hydroxyacetophenone;2-Bromo-2'-hydroxylacetophenone;2-(2-bromoacetyl)hydroxybenzene;2-Bromo-2'-hydroxyacetophenone 97%;2-Bromo-2'-hydroxyacetophenone ,97%
CBNumber
CB6675345
Molecular Formula
C8H7BrO2
Formula Weight
215.04
MOL File
2491-36-3.mol
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2-Bromo-2′-hydroxyacetophenone Property

Melting point:
44-48 °C(lit.)
Boiling point:
152-158 °C(Press: 18 Torr)
Density 
1.622±0.06 g/cm3(Predicted)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,2-8°C
solubility 
Chloroform, Methanol
pka
7.63±0.30(Predicted)
form 
Solid
color 
Yellow
Sensitive 
Lachrymatory
CAS DataBase Reference
2491-36-3(CAS DataBase Reference)
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Safety

Hazard Codes 
C
Risk Statements 
22-34
Safety Statements 
26-36/37/39-45
RIDADR 
UN 3263 8/PG 2
WGK Germany 
3
RTECS 
KM5556400
Hazard Note 
Corrosive/Lachrymatory/Keep Cold
HazardClass 
8
PackingGroup 
II
HS Code 
29147000
Toxicity
mouse,LD50,oral,821mg/kg (821mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)LUNGS, THORAX, OR RESPIRATION: DYSPNEABEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD,Acute Toxicity Data. Journal of the American College of Toxicology, Part B. Vol. 1, Pg. 183, 1992.
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H302Harmful if swallowed

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
594938
Product name
2-Bromo-2′-hydroxyacetophenone
Purity
97%
Packaging
1g
Price
$70.5
Updated
2022/05/15
Sigma-Aldrich
Product number
594938
Product name
2-Bromo-2′-hydroxyacetophenone
Purity
97%
Packaging
5g
Price
$137
Updated
2022/05/15
TCI Chemical
Product number
B4735
Product name
2-Bromo-2'-hydroxyacetophenone
Packaging
1G
Price
$75
Updated
2025/07/31
TCI Chemical
Product number
B4735
Product name
2-Bromo-2'-hydroxyacetophenone
Packaging
5G
Price
$225
Updated
2025/07/31
TRC
Product number
B684455
Product name
2-Bromo-2’-hydroxyacetophenone
Packaging
1g
Price
$205
Updated
2021/12/16
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2-Bromo-2′-hydroxyacetophenone Chemical Properties,Usage,Production

Chemical Properties

Off-White Powder

Uses

2-Bromo-2′-hydroxyacetophenone is used as a pharmaceutical intermediate.

Synthesis

118-93-4

2491-36-3

The general procedure for the synthesis of 2-bromo-1-(2-hydroxyphenyl)ethanone from 2'-hydroxyacetophenone is as follows: in a 50 mL round-bottomed flask equipped with a magnetic stirrer, 2'-hydroxyacetophenone (10 mmol) was added. Subsequently, potassium bromide (40 mmol) dissolved in 20 mL of water was added to this solution and mixed with stirring at room temperature. Next, 30% hydrogen peroxide (4 mmol) was slowly added. Vanadium (V) complex (0.01 mmol) and 70% perchloric acid (4 mmol) were further added to the reaction system, and the reaction mixture was stirred at 0°C, followed by raising to room temperature and continued stirring for 10 minutes. Under continuous stirring conditions, additional 70% perchloric acid (4 mmol) was added every 10 min for three times. The reaction process was monitored by thin layer chromatography (TLC). The nuclear magnetic resonance (NMR) spectral data of the final brominated product is detailed in the Supporting Information.

References

[1] Tetrahedron Letters, 2009, vol. 50, # 6, p. 700 - 703
[2] Tetrahedron, 2001, vol. 57, # 11, p. 2203 - 2211
[3] Archiv der Pharmazie, 2009, vol. 342, # 9, p. 541 - 545
[4] Synthetic Communications, 2006, vol. 36, # 19, p. 2877 - 2881
[5] Journal of Organometallic Chemistry, 2018, vol. 876, p. 10 - 16

2-Bromo-2′-hydroxyacetophenone Preparation Products And Raw materials

Raw materials

Bromine Acetic acid 2'-Hydroxyacetophenone

Preparation Products

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2-Bromo-2′-hydroxyacetophenone Suppliers

Australia 1 Canada 2 China 100 Europe 2 France 1 Germany 3 India 8 Switzerland 3 United Kingdom 9 United States 24 Global 153
Toronto Research Chemicals Inc.
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6668
Advantage
58
Toronto Research Chemicals
Tel
--
Fax
--
Email
info@trc-canada.com
Country
Canada
ProdList
6038
Advantage
71
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View Lastest Price from 2-Bromo-2′-hydroxyacetophenone manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Bromo-2′-hydroxyacetophenone 2491-36-3
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-05-23
Henan Aochuang Chemical Co.,Ltd.
Product
2-BROMO-2'-HYDROXYACETOPHENONE 2491-36-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-30

2491-36-3, 2-Bromo-2′-hydroxyacetophenoneRelated Search:

3-BROMOCHROMONE 2-BROMO-2'-METHOXYACETOPHENONE 2-BROMO-2',5'-DIMETHOXYACETOPHENONE 2-Bromo-2′,4′-dimethoxyacetophenone 2'-BROMO-4'-HYDROXYACETOPHENONE,2-BROMO-4'-HYDROXYACETOPHENONE,ALPHA-BROMO-4-HYDROXYACETOPHENONE,2-Bromo-4-Hydroxyacetophenone98%,α-Bromo-4-hydroxyacetophenone 5-Bromo-2-hydroxyacetophenone w-Bromo-4-Hydroxyacetophenone,OMEGA-BROMO-4-HYDROXYACETOPHENONE 3',5'-Dibromo-4'-hydroxyacetophenone 4'-BROMO-2-HYDROXYACETOPHENONE 3',5'-Dibromo-2'-hydroxyacetophenone 4-BROMO-2-HYDROXYACETOPHENONE,4-Bromo-2-hydroxyacetophenone ,97% 3'-BROMO-5'-CHLORO-2'-HYDROXYACETOPHENONE 2'-Hydroxyacetophenone 2-BROMO-2'-HYDROXYACETOPHENONE OXIME 2-Bromo-3'-hydroxyacetophenone 3'-BROMO-4'-HYDROXYACETOPHENONE 2,3-DIBROMO-1-(5-CHLORO-2-HYDROXYPHENYL)-3-PHENYLPROPAN-1-ONE 2-BROMO-2,3-DIHYDRO-4,7-DIMETHOXY-1H-INDEN-1-ONE

  • 2-Bromo-2'-hydroxyacetophenone ,97%
  • 2-Bromo-2'-hydroxyacetophenone, 2-Bromo-1-(2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)phenol
  • 2-broMo-1-(2-hydroxyphenyl)ethan-1-one
  • 2-Bromo-2'-hydroxyacetophenone 97%
  • JR-8498, 2-Bromo-1-(2-hydroxyphenyl)ethanone, 97%
  • 2-bromo-1-(2-hydroxyphenyl)-ethanon
  • 2-HYDROXYPHENACYL BROMIDE
  • 2-BROMO-1-(2-HYDROXYPHENYL)ETHANONE
  • 2-BROMO-2'-HYDROXYACETOPHENONE
  • 2-Bromo-2'-hydroxylacetophenone
  • Ethanone, 2-bromo-1-(2-hydroxyphenyl)-
  • 2-(2-bromoacetyl)hydroxybenzene
  • 2-AMINO-3&#39
  • 2-Bromo-2’-hydroxyacetophenone
  • 2-Bromo-2&#8242
  • Cyclohexane Impurity 4
  • 2491-36-3
  • BrCH2COC6H4OH
  • Organic Building Blocks
  • Ketones
  • Building Blocks
  • C7 to C8
  • Carbonyl Compounds
  • Intermediate of Neticonazole Hydrochloride
  • API intermediates
  • Aromatics
  • C7 to C8
  • Carbonyl Compounds
  • Ketones