2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro-
- Product Name
- 2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro-
- CAS No.
- 220568-33-2
- Chemical Name
- 2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro-
- Synonyms
- Br-PEG3-THP;romo-PEG3-THP;THP-PEG2-CH2CH2Br;2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro-
- CBNumber
- CB38885385
- Molecular Formula
- C11H21BrO4
- Formula Weight
- 297.19
- MOL File
- 220568-33-2.mol
2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- Property
- Boiling point:
- 361.7±42.0 °C(Predicted)
- Density
- 1.28±0.1 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- Chemical Properties,Usage,Production
Uses
Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Bromo-PEG3-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2H-Pyran, 2-[2-[2-(2-bromoethoxy)ethoxy]ethoxy]tetrahydro- manufacturers
- Product
- Br-PEG3-THP 220568-33-2
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-25