2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran
- Product Name
- 2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran
- CAS No.
- 152065-54-8
- Chemical Name
- 2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran
- Synonyms
- Br-PEG2-THP;2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran;2H-Pyran, 2-[2-(2-bromoethoxy)ethoxy]tetrahydro-
- CBNumber
- CB65574591
- Molecular Formula
- C9H17BrO3
- Formula Weight
- 253.13
- MOL File
- 152065-54-8.mol
2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran Property
- Boiling point:
- 314.3±37.0 °C(Predicted)
- Density
- 1.31±0.1 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran Chemical Properties,Usage,Production
Uses
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Biological Activity
Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
IC 50
PEGs
References
[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-[2-(2-Bromoethoxy)ethoxy]tetrahydro-2H-pyran manufacturers
- Product
- Br-PEG2-THP 152065-54-8
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-25