ChemicalBook > CAS DataBase List > 1,1'-(bromomethylene)bis(4-fluorobenzene)

1,1'-(bromomethylene)bis(4-fluorobenzene)

Product Name
1,1'-(bromomethylene)bis(4-fluorobenzene)
CAS No.
345-90-4
Chemical Name
1,1'-(bromomethylene)bis(4-fluorobenzene)
Synonyms
Flunarizine Impurity 16;4,4'-Difluor-benzhydrylbromid;4,4'-Difluorobenzhydryl Bromide;bromobis(4-fluorophenyl)methane;bis(4-fluorophenyl)methylbromide;Bis-(4-fluorophenyl)bromomethane;4,4'-DIFLUORO-DIPHENYL-BROMOMETHANE;4,4'-(bromomethylene)bis(fluorobenzene);1,1'-(bromomethylene)bis(4-fluorobenzene);Benzene,1,1'-(bromomethylene)bis[4-fluoro-
CBNumber
CB3898662
Molecular Formula
C13H9BrF2
Formula Weight
283.11
MOL File
345-90-4.mol
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1,1'-(bromomethylene)bis(4-fluorobenzene) Property

Boiling point:
302.4±32.0 °C(Predicted)
Density 
1.480±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Acetonitrile (Slightly), Chloroform (Slightly)
form 
Oil
color 
Colourless to Beige
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B519105
Product name
4,4''-DifluorobenzhydrylBromide
Packaging
500mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
J97602
Product name
1,1'-(Bromomethylene)bis(4-fluorobenzene)
Packaging
1g
Price
$30
Updated
2021/12/16
AK Scientific
Product number
J97602
Product name
1,1'-(Bromomethylene)bis(4-fluorobenzene)
Packaging
5g
Price
$100
Updated
2021/12/16
AK Scientific
Product number
X4678
Product name
1,1'-(Bromomethylene)bis(4-fluorobenzene)
Packaging
5g
Price
$134
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0044222
Product name
4,4'-(BROMOMETHYLENE)BIS(FLUOROBENZENE)
Purity
95.00%
Packaging
1G
Price
$499.8
Updated
2021/12/16
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1,1'-(bromomethylene)bis(4-fluorobenzene) Chemical Properties,Usage,Production

Uses

4,4''-Difluorobenzhydryl Bromide can be prepared as MAGL inhibitors

Synthesis

365-24-2

345-90-4

II. General procedure for the synthesis of bis-(4-fluorophenyl)bromomethane: In a sealed tube, 4,4'-difluorodiphenylmethanol (700 mg) was dissolved in 33% hydrobromic acid solution in acetic acid (6 mL) and stirred at room temperature for 1.75 h. The reaction was then heated to 100 °C for 3 h. The reaction was quenched with saturated aqueous sodium bicarbonate. After completion of the reaction, the reaction was cooled to room temperature and quenched with saturated aqueous sodium bicarbonate solution. The reaction mixture was extracted with ether, the organic layer was separated, dried over anhydrous sodium sulfate and filtered. The solvent was removed by concentration under reduced pressure and the residue was purified by rapid chromatography on a short silica gel column, using a 1:3 mixture of ethyl acetate/hexane as eluent, to afford the light yellow oily target product bis-(4-fluorophenyl)bromomethane (690 mg, 76% yield).

References

[1] Organic Letters, 2017, vol. 19, # 8, p. 2054 - 2057
[2] Journal of the American Chemical Society, 2010, vol. 132, # 27, p. 9286 - 9288
[3] Patent: WO2008/79371, 2008, A1. Location in patent: Page/Page column 99-100
[4] Organic Letters, 2011, vol. 13, # 1, p. 98 - 101
[5] Pharmazie, Beih. 2 <1947> 99, 147,

1,1'-(bromomethylene)bis(4-fluorobenzene) Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 1,1'-(bromomethylene)bis(4-fluorobenzene) manufacturers

Henan Fengda Chemical Co., Ltd
Product
1,1'-(bromomethylene)bis(4-fluorobenzene) 345-90-4
Price
US $101.00-1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2023-12-28
Career Henan Chemical Co
Product
1,1'-(bromomethylene)bis(4-fluorobenzene) 345-90-4
Price
US $9.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
1kg -1000kg
Release date
2020-01-02

345-90-4, 1,1'-(bromomethylene)bis(4-fluorobenzene)Related Search:

2-Bromofluorobenzene 4,4',4''-TRIFLUOROTRITYL BROMIDE 3-Fluorobenzyl bromide 1,1'-(bromomethylene)bis(4-fluorobenzene)

  • Benzene,1,1'-(bromomethylene)bis[4-fluoro-
  • 1,1'-(bromomethylene)bis(4-fluorobenzene)
  • 4,4'-DIFLUORO-DIPHENYL-BROMOMETHANE
  • Bis-(4-fluorophenyl)bromomethane
  • 1-[bromo-(4-fluorophenyl)methyl]-4-fluorobenzene
  • 1-[bromo-(4-fluorophenyl)methyl]-4-fluoro-benzene
  • bromobis(4-fluorophenyl)methane
  • bis(4-fluorophenyl)methylbromide
  • 4,4'-Difluor-benzhydrylbromid
  • 4,4'-Difluorobenzhydryl Bromide
  • Flunarizine Impurity 16
  • 4,4'-(bromomethylene)bis(fluorobenzene)
  • 1,1′-(Bromomethylene)bis(4-fluorobenzene), CAS 345-90-4
  • 345-90-4