fluclorolone acetonide
- Product Name
- fluclorolone acetonide
- CAS No.
- 3693-39-8
- Chemical Name
- fluclorolone acetonide
- Synonyms
- Topilar;RS-2252;Flulorolone;Fluclorolone;Flucloronide;Flucortolone acetonide;Flucloronide (Fluclorolone Acetonide);9α,11β-Dichloro-6α-fluoro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione;9α,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17α-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
- CBNumber
- CB3900941
- Molecular Formula
- C24H29Cl2FO5
- Formula Weight
- 487.392
- MOL File
- 3693-39-8.mol
fluclorolone acetonide Property
- Boiling point:
- 598.3±50.0 °C(Predicted)
- Density
- 1.38±0.1 g/cm3(Predicted)
- pka
- 12.87±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H361Suspected of damaging fertility or the unborn child
H362May cause harm to breast-fed children
H373May cause damage to organs through prolonged or repeated exposure
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P263Avoid contact during pregnancy/while nursing.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P281Use personal protective equipment as required.
P308+P313IF exposed or concerned: Get medical advice/attention.
P314Get medical advice/attention if you feel unwell.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- F418900
- Product name
- Flucloronide
- Packaging
- 2.5mg
- Price
- $165
- Updated
- 2021/12/16
- Product number
- F418900
- Product name
- Flucloronide
- Packaging
- 25mg
- Price
- $1320
- Updated
- 2021/12/16
- Product number
- API0016509
- Product name
- FLUCLORONIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $495.19
- Updated
- 2021/12/16
fluclorolone acetonide Chemical Properties,Usage,Production
Originator
Topilar,Syntex,UK,1971
Uses
fluclorolone acetonide is a synthetic glucocorticoid with anti-inflammatory properties. Studies suggest that it is a potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis.
Definition
ChEBI: Fluclorolone acetonide is a 21-hydroxy steroid.
Manufacturing Process
To 6α-fluoro-16α-hydroxy-hydrocortisone 21-acetate, described by Mills et al,
J. Am. Chem. Soc., volume 81, pages 1264 to 1265, March 5, 1959, there
was added acetic anhydride in dry pyridine. The reaction mixture was left at
room temperature overnight and was then poured with stirring into ice water.
The resulting precipitate was filtered, washed with water and crystallized from
acetone-hexane to give 6α-fluoro-16α-hydroxy-hydrocortisone-16α,21-
diacetate. This was reacted with methane-sulfonyl chloride in dimethyl
formamide in the presence of pyridine at 80°C for 1 hour. The mixture was
cooled, diluted with water and extracted with ethyl acetate. The extract was
washed with water, dried over anhydrous sodium sulfate and the ethyl acetate
was evaporated. By recrystallization of the residue from acetone-hexane there
was obtained 6α-fluoro-Δ4,9(11)-pregnadiene-16α,17α,21-triol-3,20-dione-
16α,21-diacetate.
This was reacted with chlorine to give the dichloropregnene compound, then
with selenium dioxide to give the dichloropregnadiene compound. By
hydrolysis with methanolic potassium hydroxide there was obtained the free
6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione. By
treatment with acetone in the presence of perchloric acid, the 16,17-acetonide
of 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione
was formed.
Therapeutic Function
Glucocorticoid
fluclorolone acetonide Preparation Products And Raw materials
Raw materials
Preparation Products
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