ChemicalBook > CAS DataBase List > fluclorolone acetonide

fluclorolone acetonide

Product Name
fluclorolone acetonide
CAS No.
3693-39-8
Chemical Name
fluclorolone acetonide
Synonyms
Topilar;RS-2252;Flulorolone;Fluclorolone;Flucloronide;Flucortolone acetonide;Flucloronide (Fluclorolone Acetonide);9α,11β-Dichloro-6α-fluoro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione-16,17-acetonide;9,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione;9α,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17α-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
CBNumber
CB3900941
Molecular Formula
C24H29Cl2FO5
Formula Weight
487.392
MOL File
3693-39-8.mol
More
Less

fluclorolone acetonide Property

Boiling point:
598.3±50.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
pka
12.87±0.10(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H361Suspected of damaging fertility or the unborn child

H362May cause harm to breast-fed children

H373May cause damage to organs through prolonged or repeated exposure

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P263Avoid contact during pregnancy/while nursing.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P281Use personal protective equipment as required.

P308+P313IF exposed or concerned: Get medical advice/attention.

P314Get medical advice/attention if you feel unwell.

P405Store locked up.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

TRC
Product number
F418900
Product name
Flucloronide
Packaging
2.5mg
Price
$165
Updated
2021/12/16
TRC
Product number
F418900
Product name
Flucloronide
Packaging
25mg
Price
$1320
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0016509
Product name
FLUCLORONIDE
Purity
95.00%
Packaging
5MG
Price
$495.19
Updated
2021/12/16
More
Less

fluclorolone acetonide Chemical Properties,Usage,Production

Originator

Topilar,Syntex,UK,1971

Uses

fluclorolone acetonide is a synthetic glucocorticoid with anti-inflammatory properties. Studies suggest that it is a potent inhibitor of mouse skin tumor promotion and epidermal DNA synthesis.

Definition

ChEBI: Fluclorolone acetonide is a 21-hydroxy steroid.

Manufacturing Process

To 6α-fluoro-16α-hydroxy-hydrocortisone 21-acetate, described by Mills et al, J. Am. Chem. Soc., volume 81, pages 1264 to 1265, March 5, 1959, there was added acetic anhydride in dry pyridine. The reaction mixture was left at room temperature overnight and was then poured with stirring into ice water. The resulting precipitate was filtered, washed with water and crystallized from acetone-hexane to give 6α-fluoro-16α-hydroxy-hydrocortisone-16α,21- diacetate. This was reacted with methane-sulfonyl chloride in dimethyl formamide in the presence of pyridine at 80°C for 1 hour. The mixture was cooled, diluted with water and extracted with ethyl acetate. The extract was washed with water, dried over anhydrous sodium sulfate and the ethyl acetate was evaporated. By recrystallization of the residue from acetone-hexane there was obtained 6α-fluoro-Δ4,9(11)-pregnadiene-16α,17α,21-triol-3,20-dione- 16α,21-diacetate.
This was reacted with chlorine to give the dichloropregnene compound, then with selenium dioxide to give the dichloropregnadiene compound. By hydrolysis with methanolic potassium hydroxide there was obtained the free 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione. By treatment with acetone in the presence of perchloric acid, the 16,17-acetonide of 6α-fluoro-9α,11β-dichloro-Δ1,4-pregnadiene-16α,17α,21-triol-3,20-dione was formed.

Therapeutic Function

Glucocorticoid

fluclorolone acetonide Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

fluclorolone acetonide Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15402
Advantage
60
Shanghai TaoSu Biochemical Technology Co., Ltd.
Tel
021-33632979
Fax
021-34692979
Email
info@tsbiochem.com
Country
China
ProdList
8065
Advantage
58
BOC Sciences
Tel
16314854226
Email
info@bocsci.com
Country
United States
ProdList
9923
Advantage
65
Shenzhen Polymeri Biochemical Technology Co., Ltd.
Tel
+86-400-002-6226 +86-13028896684;
Email
sales@rrkchem.com
Country
China
ProdList
57423
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
Advantage
58
Hubei Jusheng Technology Co.,Ltd.
Tel
18871490254
Fax
027-59599243
Email
linda@hubeijusheng.com
Country
CHINA
ProdList
28172
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58

3693-39-8, fluclorolone acetonideRelated Search:


  • Flucloronide
  • Fluclorolone
  • Flulorolone
  • (6α,11β,16α)-9,11-Dichloro-6-fluoro-21-hydroxy-16,17-[(1-Methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione
  • 9,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17-(isopropylidenedioxy)pregna-1,4-diene-3,20-dione
  • 9α,11β-Dichloro-6α-fluoro-16α,17α,21-trihydroxypregna-1,4-diene-3,20-dione-16,17-acetonide
  • Flucortolone acetonide
  • 9α,11β-Dichloro-6α-fluoro-21-hydroxy-16α,17α-(isopropylidenebisoxy)pregna-1,4-diene-3,20-dione
  • RS-2252
  • Topilar
  • Flucloronide (Fluclorolone Acetonide)
  • Pregna-1,4-diene-3,20-dione, 9,11-dichloro-6-fluoro-21-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]-, (6α,11β,16α)-
  • 3693-39-8
  • C24H29Cl2FO5
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Steroids
  • Inhibitors, Pharmaceuticals, Intermediates & Fine Chemicals, Steroids