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4-hydroxybutanal

Product Name
4-hydroxybutanal
CAS No.
25714-71-0
Chemical Name
4-hydroxybutanal
Synonyms
4-Hydroxybutanal;Einecs 247-205-3;Butanal, 4-hydroxy-;4-hydroxybutyraldehyde;gamma-Hydroxybutyraldehyde;4-hydroxybutanal Basic information;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran (Equilibrium Mixture)
CBNumber
CB3901650
Molecular Formula
C4H8O2
Formula Weight
88.11
MOL File
25714-71-0.mol
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4-hydroxybutanal Property

Boiling point:
103.07°C (rough estimate)
Density 
1.0808
refractive index 
1.4384
storage temp. 
Refrigerator
solubility 
Chloroform (Sparingly), Ethyl Acetate (Slightly)
form 
Oil
pka
14.89±0.10(Predicted)
color 
Colourless
Stability:
Hygroscopic
EPA Substance Registry System
Butanal, 4-hydroxy- (25714-71-0)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
B443928
Product name
4-Hydroxybutanal
Packaging
100mg
Price
$195
Updated
2021/12/16
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4-hydroxybutanal Chemical Properties,Usage,Production

Uses

4-Hydroxybutanal is used in preparation of deoxykeoses and acetonides. 4-Hydroxybutanal is also a metabolite of Tegafur , a prodrug used for various cancer chemotherapies.

Reactions

4-Hydroxybutanal forms a cyclic hemiacetal when the hydroxyl oxygen add to the aldehyde group. Methanol reacts with this cyclic hemiacetal to form 2-methoxytetrahydrofuran which is our desired product.2-Methoxytetrahydrofuran is a cyclic acetal. The hydroxyl oxygen of 4-Hydroxybutanal reacts with the aldehyde to form cyclic ether linkage.

Synthesis

The 4-hydroxybutanal which is produced as the high yield product of the invention hydroformylation process can be separated and recovered by conventional distillation procedures. It is highly preferred, however, to subject the hydroformylation product mixture to aqueous phase extraction. Surprisingly it was found that water is capable of extracting 4-hydroxybutanal from the product mixture substantially to the exclusion of the other product mixture components. In a commercial scale operation, an aqueous phase stream can be contacted countercurrently and continuously with reaction product effluent from the hydroformylation reaction zone. The resultant aqueous phase containing 4-hydroxybutanal is an excellent vehicle for subsequent processing procedures, such as hydrogenation of 4-hydroxybutanal with Raney nickel to produce valuable 1,4-butanediol.
literature source US04064145

References

[1] QINGYONG MENG Ming B H Chenggen Zhang. A theoretical model study on the cyclic reaction of 4-hydroxybutanal catalyzed by Br?nsted acid[J]. Canadian Journal of Chemistry, 2009, 68 1: 1610-1619. DOI:10.1139/V09-126.
[2] LUDMILA LEITE. Transformation of 4-hydroxybutanal over porcelain[J]. Journal of Molecular Catalysis A: Chemical, 1999, 144 2: Pages 323-328. DOI:10.1016/S1381-1169(98)00382-3.
[3] https://patents.google.com/patent/CN114149312A/en

4-hydroxybutanal Preparation Products And Raw materials

Raw materials

Preparation Products

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4-hydroxybutanal Suppliers

China 42 India 1 Switzerland 1 United States 2 Global 46
Beijing HwrkChemical Technology Co., Ltd
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View Lastest Price from 4-hydroxybutanal manufacturers

Henan Aochuang Chemical Co.,Ltd.
Product
4-hydroxybutanal Basic information 25714-71-0
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-11-25

25714-71-0, 4-hydroxybutanalRelated Search:


  • 4-hydroxybutyraldehyde
  • 4-Hydroxybutanal
  • Butanal, 4-hydroxy-
  • Einecs 247-205-3
  • gamma-Hydroxybutyraldehyde
  • 4-Hydroxybutanal and 2-Hydroxytetrahydrofuran (Equilibrium Mixture)
  • 4-Hydroxybutanal and 2-Hydroxytetrahydrofuran
  • 4-hydroxybutanal Basic information
  • 25714-71-0