4-hydroxybutanal
- Product Name
- 4-hydroxybutanal
- CAS No.
- 25714-71-0
- Chemical Name
- 4-hydroxybutanal
- Synonyms
- 4-Hydroxybutanal;Einecs 247-205-3;Butanal, 4-hydroxy-;4-hydroxybutyraldehyde;gamma-Hydroxybutyraldehyde;4-hydroxybutanal Basic information;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran;4-Hydroxybutanal and 2-Hydroxytetrahydrofuran (Equilibrium Mixture)
- CBNumber
- CB3901650
- Molecular Formula
- C4H8O2
- Formula Weight
- 88.11
- MOL File
- 25714-71-0.mol
4-hydroxybutanal Property
- Boiling point:
- 103.07°C (rough estimate)
- Density
- 1.0808
- refractive index
- 1.4384
- storage temp.
- Refrigerator
- solubility
- Chloroform (Sparingly), Ethyl Acetate (Slightly)
- form
- Oil
- pka
- 14.89±0.10(Predicted)
- color
- Colourless
- Stability:
- Hygroscopic
- EPA Substance Registry System
- Butanal, 4-hydroxy- (25714-71-0)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B443928
- Product name
- 4-Hydroxybutanal
- Packaging
- 100mg
- Price
- $195
- Updated
- 2021/12/16
4-hydroxybutanal Chemical Properties,Usage,Production
Uses
4-Hydroxybutanal is used in preparation of deoxykeoses and acetonides. 4-Hydroxybutanal is also a metabolite of Tegafur , a prodrug used for various cancer chemotherapies.
Reactions
4-Hydroxybutanal forms a cyclic hemiacetal when the hydroxyl oxygen add to the aldehyde group. Methanol reacts with this cyclic hemiacetal to form 2-methoxytetrahydrofuran which is our desired product.2-Methoxytetrahydrofuran is a cyclic acetal. The hydroxyl oxygen of 4-Hydroxybutanal reacts with the aldehyde to form cyclic ether linkage.
Synthesis
The 4-hydroxybutanal which is produced as the high yield product of the invention hydroformylation process can be separated and recovered by conventional distillation procedures. It is highly preferred, however, to subject the hydroformylation product mixture to aqueous phase extraction. Surprisingly it was found that water is capable of extracting 4-hydroxybutanal from the product mixture substantially to the exclusion of the other product mixture components. In a commercial scale operation, an aqueous phase stream can be contacted countercurrently and continuously with reaction product effluent from the hydroformylation reaction zone. The resultant aqueous phase containing 4-hydroxybutanal is an excellent vehicle for subsequent processing procedures, such as hydrogenation of 4-hydroxybutanal with Raney nickel to produce valuable 1,4-butanediol.
literature source US04064145
References
[1] QINGYONG MENG Ming B H Chenggen Zhang. A theoretical model study on the cyclic reaction of 4-hydroxybutanal catalyzed by Br?nsted acid[J]. Canadian Journal of Chemistry, 2009, 68 1: 1610-1619. DOI:10.1139/V09-126.
[2] LUDMILA LEITE. Transformation of 4-hydroxybutanal over porcelain[J]. Journal of Molecular Catalysis A: Chemical, 1999, 144 2: Pages 323-328. DOI:10.1016/S1381-1169(98)00382-3.
[3] https://patents.google.com/patent/CN114149312A/en
4-hydroxybutanal Preparation Products And Raw materials
Raw materials
Preparation Products
4-hydroxybutanal Suppliers
- Tel
- 18515581800 18501085097
- Fax
- 010-89508210
- sales.bj@hwrkchemical.com
- Country
- China
- ProdList
- 9400
- Advantage
- 55
- Tel
- 22-58627059 13920586291
- Fax
- 022-58620305
- zdcomcon@126.com
- Country
- China
- ProdList
- 3829
- Advantage
- 50
- Tel
- 0755-0755-66853366 13670046396
- Fax
- 0755-28363542
- sales@chem-strong.com
- Country
- China
- ProdList
- 18333
- Advantage
- 56
- Tel
- 15221275939
- Fax
- 021-50706099
- shenlinxing@macklin.cn
- Country
- China
- ProdList
- 15873
- Advantage
- 55
- Tel
- 025-66028182 18626450290
- yftan@aikonchem.com
- Country
- China
- ProdList
- 16679
- Advantage
- 50
- Tel
- 023-86822659 18611316925
- sales@acemol.com
- Country
- China
- ProdList
- 993
- Advantage
- 55
- Tel
- 021-61469567 13482353728
- Fax
- 021-61161605
- sales@fdc-chemical.com
- Country
- China
- ProdList
- 9717
- Advantage
- 58
- Tel
- 400-400-1332688 18019345275
- Fax
- 400-133-2688
- amy@rhawn.cn
- Country
- China
- ProdList
- 14948
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 2559355526@qq.com
- Country
- China
- ProdList
- 14193
- Advantage
- 58
- Tel
- 021-58958002 18930822973
- Fax
- 021-58958618
- sales@uhnshanghai.com
- Country
- China
- ProdList
- 1984
- Advantage
- 58
View Lastest Price from 4-hydroxybutanal manufacturers
- Product
- 4-hydroxybutanal Basic information 25714-71-0
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1000kg
- Release date
- 2025-11-25