2-methoxy-4-prop-1-enylphenetole Property

FEMA 

2472 | ISOEUGENYL ETHYL ETHER

solubility 

Practically insoluble in water, soluble in alcohol and oils.

form 

White or colourless crystals.

Odor

at 100.00 %. spicy carnation clove

Odor Type

spicy

JECFA Number

1267

LogP

3.58

EPA Substance Registry System

Benzene, 1-ethoxy-2-methoxy-4-(1-propenyl)- (7784-67-0)

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H317May cause an allergic skin reaction

H319Causes serious eye irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

2-methoxy-4-prop-1-enylphenetole Chemical Properties,Usage,Production

Description

Isoeugenyl ethyl ether has an odor similar to isoeugenol. Prepared from isoeugenol by boiling with ethyl p-toluenesulfonate.

Chemical Properties

Isoeugenyl ethyl ether has an odor similar to isoeugenol.

Uses

Ethylisoeugenol is a prenylated dehydrozingerone analog, a potent potential chemopreventive agent for cancer.

Application

2-methoxy-4-prop-1-enylphenetole is an excellent sweetener, stable in soap, and it does not discolour in cosmetic preparations as easily as Eugenol, Vanillin, etc. 2-methoxy-4-prop-1-enylphenetole may meanwhile become a popular fragrance chemical for its very pleasant effect and great tenacity. It blends very well with Oakmoss, Ylang, Methylionones, Patchouli, Coumarins, etc. However, cosmetic skin research is very concerned about the Propenyl group, which is accused of being a hazard to the human skin, which would bring Eugenolderivatives under the limelight and possibly ban them from use in cosmetic fragrances.

Preparation

From isoeugenol by boiling with ethyl p-toluenesulfonate.

Synthesis Reference(s)

Synthetic Communications, 20, p. 345, 1990 DOI: 10.1080/00397919008052774