nafiverine
- Product Name
- nafiverine
- CAS No.
- 5061-22-3
- Chemical Name
- nafiverine
- Synonyms
- DA-914;nafiverine;Nafiverina;Nafiverinum;Naftimepezine;UNII-WLT400RC9Q;EINECS 225-766-5;Bis(α-methyl-1-naphthaleneacetic acid)2,2'-(1,4-piperazinediyl)bisethyl ester;1-Naphthaleneacetic acid, α-methyl-, 1,1'-(1,4-piperazinediyldi-2,1-ethanediyl) ester;2-[4-[2-(2-naphthalen-1-ylpropanoyloxy)ethyl]piperazin-1-yl]ethyl 2-naphthalen-1-ylpropanoate
- CBNumber
- CB3907263
- Molecular Formula
- C34H38N2O4
- Formula Weight
- 538.684
- MOL File
- 5061-22-3.mol
N-Bromosuccinimide Price
- Product number
- API0016002
- Product name
- NAFIVERINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.3
- Updated
- 2021/12/16
nafiverine Chemical Properties,Usage,Production
Originator
Naftidan,De Angeli,Italy,1969
Definition
ChEBI: Nafiverine is a member of naphthalenes.
Manufacturing Process
15 grams of α-methyl-1-naphthylacetic acid were refluxed with 50 ml of thionyl chloride during 3 hours. The excess thionyl chloride was removed under reduced pressure and the product was also isolated by distillation under reduced pressure. Yield: 15.6 grams (96%). The α-methyl-1-naphthyl acetyl chloride boils at 120° to 124°C. 1.76 grams of N,N'-di-(β-hydroxyethyl)- piperazine, 1.9 grams of sodium bicarbonate and 4.45 grams of α-methyl-1- naphthyl acetyl chloride in 30 ml of anhydrous acetonitrile were refluxed with stirring during 5 hours. After cooling the mixture was filtered and the acetonitrile evaporated off under reduced pressure. 5.2 grams of crude ester were obtained. The hydrochloride, melting at 220° to 221°C, may be prepared by dissolving the ester in absolute ethanol and treating the solution with anhydrous gaseous hydrogen chloride.
Therapeutic Function
Spasmolytic
nafiverine Preparation Products And Raw materials
Raw materials
Preparation Products
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