1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

Product Name: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
CAS No.: 122-96-3
Chemical Name: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
Synonyms: AKOS BB-4936;1,4-BIS(2-HYDROXYETH;1,4-PIPERAZINEDIETHANOL;N,N'-PIPERAZINDIETHANOL;N,N'-PIPERAZINEDIETHANOL;piperazine-1,4-diethanol;Piperazine-1,4-bisethanol;DI(HYDROXYETHYL)PIPERAZINE;N,N'-Dihydroxyethylpiperazine;4-BIS(2-HYDROXYETHYL)PIPERAZINE
CBNumber: CB3115114
Molecular Formula: C8H18N2O2
Formula Weight: 174.24
MOL File: 122-96-3.mol

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Property

Melting point:: 133.5-136 °C(lit.)
Boiling point:: 215-220 °C50 mm Hg(lit.)
Density: 1.097
vapor pressure: 0.004Pa at 20℃
refractive index: 1.4540 (estimate)
Flash point:: 166℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 14.66±0.10(Predicted)
color: White to Almost white
Water Solubility: Soluble in water.
InChIKey: VARKIGWTYBUWNT-UHFFFAOYSA-N
LogP: -1.92 at 20℃
CAS DataBase Reference: 122-96-3(CAS DataBase Reference)
EPA Substance Registry System: 1,4-Piperazinediethanol (122-96-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
RTECS: TL3675000
TSCA: Yes
HS Code: 2933.59.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B45402
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: 99%
Packaging: 5g
Price: $62.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: B45402
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: 99%
Packaging: 25g
Price: $189
Updated: 2025/07/31

TCI Chemical

Product number: B4903
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B4903
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $122
Updated: 2025/07/31

TRC

Product number: P475343
Product name: 1,4-Piperazinediethanol
Packaging: 10g
Price: $150
Updated: 2021/12/16

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.

Flammability and Explosibility

Not classified

Synthesis

111-42-2

122-96-3

The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows: Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions Operational steps: 1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 . 2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin). 3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.

References

[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,
[5] Patent: DE917784, 1952,

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Potassium carbonate Piperazine 2-Chloroethanol Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide

Preparation Products

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Suppliers

Americas 1 Belgium 2 CHINA 177 Europe 2 Germany 2 India 11 Japan 3 South Korea 1 Switzerland 2 United Kingdom 5 United States 17 Global 223

3B Pharmachem (Wuhan) International Co.,Ltd.

Tel: 821-50328103-801 18930552037
Fax: 86-21-50328109
Email: 3bsc@sina.com
Country: China
ProdList: 15838
Advantage: 69

Alfa Aesar

Tel: 400-6106006
Fax: 021-67582001/03/05
Email: saleschina@alfa-asia.com
Country: China
ProdList: 30123
Advantage: 84

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

Beijing Ouhe Technology Co., Ltd

Tel: 010-010-82967028 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 12000
Advantage: 60

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15883
Advantage: 64

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

Beijing Isomersyn Technology CO;LTD

Tel: 010-82954736 13391601435
Email: sales@isomersyn.com
Country: China
ProdList: 3295
Advantage: 57

Syntechem Co.,Ltd

Tel
Fax: E-Mail Inquiry
Email: info@syntechem.com
Country: China
ProdList: 12984
Advantage: 57

Tangshan Moneide Trading Co., Ltd.

Tel: 0315-8309571 15633399667
Fax: +86-315-7726572
Email: sales@moneidechem.com
Country: China
ProdList: 704
Advantage: 57

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View Lastest Price from 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE manufacturers

Dideu Industries Group Limited

Product: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-09-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,4-Bis(2-hydroxyethyl)piperazine 122-96-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-07

122-96-3, 1,4-BIS(2-HYDROXYETHYL)PIPERAZINERelated Search:

Simetride 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Piperazine-N,N'-bis(2-hydroxypropanesulphonic acid) disodium salt POPSO HEPPSO sodium nafiverine Piperazine-N,N'-bis(2-hydroxypropanesulfonic acid) sesquisodium salt HEPPSO zipeprol gypsetin Aranotine Apicycline Febuverine 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-8-(4-(2-hydroxyethyl)piperazi nyl)-1-(2-hydroxy-3-(4-(2-hydroxyethyl)piperazinyl)propyl)- 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-1-(2-hydroxy-3-(4-(2-hydroxye thyl)piperazinyl)propyl)- 1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE 2-PHENOXY-1-[4-(2-PHENOXY-ACETYL)-PIPERAZIN-1-YL]-ETHANONE

DI(HYDROXYETHYL)PIPERAZINE

AKOS BB-4936

2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL

1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-PIPERAZINEDIETHANOL

1,4-Bis(beta-hydroxyethyl)piperazine

1,4-Di(2-hydroxyethyl)piperazine

n,n’-bis(2-hydroxyethyl)-piperazin

n,n’-bis(beta-hydroxyethyl)piperazine

n,n’-di(2-hydroxyethyl)piperazine

N,N'-Bis(beta-hydroxyethyl)piperazine

N,N'-Di(2-hydroxyethyl)piperazine

N,N'-Dihydroxyethylpiperazine

Piperazine, N,N'-bis(2-hydroxyethyl)-

N,N'-PIPERAZINDIETHANOL

N,N'-PIPERAZINEDIETHANOL

piperazine,N,N’-bis(2-hydroxyethyl)-

piperazine-1,4-diethanol

1,4-Piperazinediethanol(6CI,7CI,8CI,9CI)

2,2''-PIPERAZINE-1,4-DIYLDIETHANOL

2,2'-(1,4-Piperazinediyl)diethanol

Piperazine-1,4-bisethanol

N,N'-Bis(2-hydroxyethyl)piperazine,99%

1,4-Bis(2-hydroxyethyl)piperazine,1,4-Piperazinediethanol

1,4-BIS(2-HYDROXYETH

1,4-<WBR>Bis(2-<WBR>hydroxyethyl)<WBR>piperazine

1,4-Bis(2-hydroxyethyl)piperazine 99%

1,4-Bis(2-hydroxyethyl)piperazine &gt

1,4-Bis(2-hydroxyethyl)piperazine,98%

4-BIS(2-HYDROXYETHYL)PIPERAZINE

TIANFU CHEM 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-Piperazinediethanol (6CI, 7CI, 8CI, 9CI, ACI)

n,n'-bis(2-hydroxyethyl)piperazine

2,2'-(Piperazine-1,4-diyl)diethanol

N,N'-Bis(2-hydroxyethyl)piperazine

122-96-3

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