1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

Product Name: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
CAS No.: 122-96-3
Chemical Name: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE
Synonyms: AKOS BB-4936;1,4-BIS(2-HYDROXYETH;1,4-PIPERAZINEDIETHANOL;N,N'-PIPERAZINDIETHANOL;N,N'-PIPERAZINEDIETHANOL;piperazine-1,4-diethanol;Piperazine-1,4-bisethanol;DI(HYDROXYETHYL)PIPERAZINE;N,N'-Dihydroxyethylpiperazine;4-BIS(2-HYDROXYETHYL)PIPERAZINE
CBNumber: CB3115114
Molecular Formula: C8H18N2O2
Formula Weight: 174.24
MOL File: 122-96-3.mol

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Property

Melting point:: 133.5-136 °C(lit.)
Boiling point:: 215-220 °C50 mm Hg(lit.)
Density: 1.097
vapor pressure: 0.004Pa at 20℃
refractive index: 1.4540 (estimate)
Flash point:: 166℃
storage temp.: Sealed in dry,Room Temperature
solubility: DMSO (Slightly), Methanol (Slightly)
form: powder to crystal
pka: 14.66±0.10(Predicted)
color: White to Almost white
Water Solubility: Soluble in water.
InChIKey: VARKIGWTYBUWNT-UHFFFAOYSA-N
LogP: -1.92 at 20℃
CAS DataBase Reference: 122-96-3(CAS DataBase Reference)
EPA Substance Registry System: 1,4-Piperazinediethanol (122-96-3)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 37/39-26
WGK Germany: 3
RTECS: TL3675000
TSCA: Yes
HS Code: 2933.59.9500

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B45402
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: 99%
Packaging: 5g
Price: $62.3
Updated: 2025/07/31

Sigma-Aldrich

Product number: B45402
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: 99%
Packaging: 25g
Price: $189
Updated: 2025/07/31

TCI Chemical

Product number: B4903
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $37
Updated: 2025/07/31

TCI Chemical

Product number: B4903
Product name: 1,4-Bis(2-hydroxyethyl)piperazine
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $122
Updated: 2025/07/31

TRC

Product number: P475343
Product name: 1,4-Piperazinediethanol
Packaging: 10g
Price: $150
Updated: 2021/12/16

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Chemical Properties,Usage,Production

Chemical Properties

white crystalline powder

Uses

1,4-Piperazinediethanol is useful in the synthesis of salt-inducible kinase inhibitors for the treatment of diseases.

Flammability and Explosibility

Not classified

Synthesis

111-42-2

122-96-3

The general procedure for the synthesis of N,N'-bis(2-hydroxyethyl)piperazine from diethanolamine is as follows: Example 2: Preparation of 1,4-bis(hydroxyethyl)piperazine from diethanolamine under solvent-free conditions Operational steps: 1. 100 g of diethanolamine (II) and 10 g of Catalyst A were added in the same reaction setup described in Example 1 . 2. Upon completion of the reaction, the reaction product was detected by gas chromatography analysis (GC column: 30m RTX Amin). 3. The analytical results showed that the content of 1,4-bis(hydroxyethyl)piperazine in the reaction product was 79% under the condition of complete conversion of diethanolamine.

References

[1] Patent: US2012/108816, 2012, A1. Location in patent: Page/Page column 6
[2] Patent: US2868791, 1954,
[3] Patent: US2636033, 1950,
[4] Patent: DE917784, 1952,
[5] Patent: DE917784, 1952,

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Ethanol Sodium sulfate Potassium carbonate Piperazine 2-Chloroethanol Ethyl acetate Hydrochloric acid Dichloromethane Sodium hydroxide

Preparation Products

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1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Suppliers

Americas 1 Belgium 2 CHINA 178 Europe 2 Germany 2 India 11 Japan 3 South Korea 1 Switzerland 2 United Kingdom 5 United States 17 Global 224

Eburon Organics bvba

Tel: --
Fax: --
Email: dany@eburon-organics.com
Country: Belgium
ProdList: 156
Advantage: 58

Eburon Organics N.V.

Tel: --
Fax: --
Email: eburon@innet.be
Country: Belgium
ProdList: 490
Advantage: 66

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View Lastest Price from 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE manufacturers

Dideu Industries Group Limited

Product: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3
Price: US $1.10/g
Min. Order: 1g
Purity: 99.9%
Supply Ability: 100 Tons Min
Release date: 2025-09-17

Zhuozhou Wenxi import and Export Co., Ltd

Product: 1,4-Bis(2-hydroxyethyl)piperazine 122-96-3
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

Career Henan Chemical Co

Product: 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE 122-96-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2018-08-07

122-96-3, 1,4-BIS(2-HYDROXYETHYL)PIPERAZINERelated Search:

Simetride 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE Piperazine-N,N'-bis(2-hydroxypropanesulphonic acid) disodium salt POPSO HEPPSO sodium nafiverine Piperazine-N,N'-bis(2-hydroxypropanesulfonic acid) sesquisodium salt HEPPSO zipeprol gypsetin Aranotine Apicycline Febuverine 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-8-(4-(2-hydroxyethyl)piperazi nyl)-1-(2-hydroxy-3-(4-(2-hydroxyethyl)piperazinyl)propyl)- 6(1H)-Purinone, 2,3-dihydro-3,7-dimethyl-1-(2-hydroxy-3-(4-(2-hydroxye thyl)piperazinyl)propyl)- 1-(4-[2-HYDROXY-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPYL]PIPERAZINO)-3-(1,3,6-TRIBROMO-9H-CARBAZOL-9-YL)PROPAN-2-OL DIHYDROCHLORIDE 1,4-BIS(2-HYDROXYPROPYL)-2-METHYLPIPERAZINE 2-PHENOXY-1-[4-(2-PHENOXY-ACETYL)-PIPERAZIN-1-YL]-ETHANONE

DI(HYDROXYETHYL)PIPERAZINE

AKOS BB-4936

2-[4-(2-HYDROXYETHYL)PIPERAZIN-1-YL]ETHANOL

1,4'-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-PIPERAZINEDIETHANOL

1,4-Bis(beta-hydroxyethyl)piperazine

1,4-Di(2-hydroxyethyl)piperazine

n,n’-bis(2-hydroxyethyl)-piperazin

n,n’-bis(beta-hydroxyethyl)piperazine

n,n’-di(2-hydroxyethyl)piperazine

N,N'-Bis(beta-hydroxyethyl)piperazine

N,N'-Di(2-hydroxyethyl)piperazine

N,N'-Dihydroxyethylpiperazine

Piperazine, N,N'-bis(2-hydroxyethyl)-

N,N'-PIPERAZINDIETHANOL

N,N'-PIPERAZINEDIETHANOL

piperazine,N,N’-bis(2-hydroxyethyl)-

piperazine-1,4-diethanol

1,4-Piperazinediethanol(6CI,7CI,8CI,9CI)

2,2''-PIPERAZINE-1,4-DIYLDIETHANOL

2,2'-(1,4-Piperazinediyl)diethanol

Piperazine-1,4-bisethanol

N,N'-Bis(2-hydroxyethyl)piperazine,99%

1,4-Bis(2-hydroxyethyl)piperazine,1,4-Piperazinediethanol

1,4-BIS(2-HYDROXYETH

1,4-<WBR>Bis(2-<WBR>hydroxyethyl)<WBR>piperazine

1,4-Bis(2-hydroxyethyl)piperazine 99%

1,4-Bis(2-hydroxyethyl)piperazine &gt

1,4-Bis(2-hydroxyethyl)piperazine,98%

4-BIS(2-HYDROXYETHYL)PIPERAZINE

TIANFU CHEM 1,4-BIS(2-HYDROXYETHYL)PIPERAZINE

1,4-Piperazinediethanol (6CI, 7CI, 8CI, 9CI, ACI)

n,n'-bis(2-hydroxyethyl)piperazine

2,2'-(Piperazine-1,4-diyl)diethanol

N,N'-Bis(2-hydroxyethyl)piperazine

122-96-3

Building Blocks

Piperazines

Heterocyclic Building Blocks

PIPERIDINE