rifamide
- Product Name
- rifamide
- CAS No.
- 2750-76-7
- Chemical Name
- rifamide
- Synonyms
- M/14;rifamide;Rifomide;Rifamycin M-14;Rifomycin M-14;rifamide USP/EP/BP;Rifamycin B diethylamide;Rifomycin B diethylamide;Rifamycin, 4-O-[2-(diethylamino)-2-oxoethyl]-
- CBNumber
- CB3908402
- Molecular Formula
- C43H58N2O13
- Formula Weight
- 810.93
- MOL File
- 2750-76-7.mol
rifamide Property
- Melting point:
- 170°C (rough estimate)
- Boiling point:
- 755.63°C (rough estimate)
- alpha
- D20 -48.7° (c = 0.4 in methanol)
- Density
- 1.1791 (rough estimate)
- refractive index
- 1.4670 (estimate)
Safety
- Toxicity
- LD50 in mice, rats (mg/kg): 2450, >4000 orally; 640, 2500 s.c.; 320, 535 i.p.; 315, 380 i.v. (Dezulian)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- AG-CN2-0332-M010
- Product name
- RifamycinM14
- Purity
- ≥95%(HPLC)
- Packaging
- 10mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- API0012412
- Product name
- RIFAMIDE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $502.55
- Updated
- 2021/12/16
rifamide Chemical Properties,Usage,Production
Uses
Antibacterial.
Pharmaceutical Applications
The diethyl amide of rifamycin B, formulated as the sodium salt for parenteral administration. It exhibits high activity against Gram-positive organisms and M. tuberculosis typical of the group. MICs for Gram-negative bacilli are of the order of 20–50 mg/L.
It is absorbed orally and is rapidly eliminated through the bile, achieving concentrations sufficient to inhibit Gramnegative bacilli. In contrast to rifampicin, it can be administered as the sodium salt by intramuscular injection. A dose of 150 mg produces mean plasma levels of about 1 mg/L. The plasma halflife is about 2 h. The same dosage produces concentrations over 1 g/L in bile and c. 40 mg/L in the gallbladder wall.
Toxicity and side effects are similar to those of other rifamycins. It has been used in staphylococcal infections and infections of the biliary tract. It is unsuitable for the treatment of tuberculosis because of insufficient distribution to the tissues.
rifamide Preparation Products And Raw materials
Raw materials
Preparation Products
rifamide Suppliers
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