1-(chloromethyl)-4-(phenylthio)benzene

Product Name: 1-(chloromethyl)-4-(phenylthio)benzene
CAS No.: 1208-87-3
Chemical Name: 1-(chloromethyl)-4-(phenylthio)benzene
Synonyms: NSC 43056;1-(Chloromethyl)-4-(phenylsulfanyl);1-(chloromethyl)-4-(phenylthio)benzene;1-(chloromethyl)-4-phenylsulfanylbenzene;Benzene, 1-(chloromethyl)-4-(phenylthio)-;(4-(Chloromethyl)phenyl)(phenyl)sulfane 2:CAS No: 10-25 gm;4-phenyl thio benzyl chloride (4-(chloromethyl)phenyl)(phenyl)sulfane
CBNumber: CB3925629
Molecular Formula: C13H11ClS
Formula Weight: 234.74
MOL File: 1208-87-3.mol

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1-(chloromethyl)-4-(phenylthio)benzene Property

Boiling point:: 372℃
Density: 1.22
Flash point:: 167℃
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
Appearance: Yellow to brown Liquid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: C371415
Product name: (4-(Chloromethyl)phenyl)(phenyl)sulfane
Packaging: 250mg
Price: $60
Updated: 2021/12/16

TRC

Product number: C371415
Product name: (4-(Chloromethyl)phenyl)(phenyl)sulfane
Packaging: 5g
Price: $225
Updated: 2021/12/16

TRC

Product number: C371415
Product name: (4-(Chloromethyl)phenyl)(phenyl)sulfane
Packaging: 2.5g
Price: $130
Updated: 2021/12/16

AK Scientific

Product number: 3649AA
Product name: (4-(Chloromethyl)phenyl)(phenyl)sulfane
Packaging: 10g
Price: $136
Updated: 2021/12/16

Matrix Scientific

Product number: 099881
Product name: (4-(Chloromethyl)phenyl)(phenyl)sulfane
Purity: 95+%
Packaging: 1g
Price: $639
Updated: 2021/12/16

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1-(chloromethyl)-4-(phenylthio)benzene Chemical Properties,Usage,Production

Uses

(4-(Chloromethyl)phenyl)(phenyl)sulfane can be used as reactant/reagent in preparation of fenticonazole nitrate by phase transfer-catalyzed benzylation of (dichlorophenyl)imidazoleethanol with (phenylthio)benzyl chloride.

Synthesis

6317-56-2

1208-87-3

The general procedure for the synthesis of 4-phenylthiobenzyl chloride from 4-phenylthiobenzyl alcohol was as follows: 518.0 g of 4-phenylthiobenzyl alcohol, 147 mL of pyridine, and 2444 mL of dichloromethane were added to a 5000 mL reaction flask at room temperature (25 °C), mixed well, and then cooled in an ice-water bath to control the temperature. Thionyl chloride was slowly added dropwise at 20-24 °C, and after completion of the dropwise addition, the reaction mixture was stirred at room temperature (25 °C) for 2 hours. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent was hexane: ethyl acetate = 10:1) until the reaction was completed. After completion of the reaction, the reaction mixture was washed with water and subsequently neutralized with water and dried with anhydrous magnesium sulfate. The dried mixture was filtered and the filtrate was concentrated to dryness under reduced pressure (pressure 1720 Pa, temperature 25 °C). After recovery of dichloromethane, 548.0 g of brownish red oily product was obtained in 97.7% yield and 99.66% HPLC purity. The product can be cured by freezing to about -10°C.

References

[1] Patent: CN107573288, 2018, A. Location in patent: Paragraph 0016; 0024
[2] Patent: CN107652238, 2018, A. Location in patent: Paragraph 0026; 0027
[3] Arzneimittel-Forschung/Drug Research, 1982, vol. 31, # 12, p. 2123 - 2126
[4] Arzneimittel-Forschung/Drug Research, 1981, vol. 31, # 12, p. 2127 - 2133
[5] Patent: US5420128, 1995, A

1-(chloromethyl)-4-(phenylthio)benzene Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(chloromethyl)-4-(phenylthio)benzene Suppliers

China 81 France 1 Germany 1 India 6 United States 6 Global 95

Aladdin Scientific

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View Lastest Price from 1-(chloromethyl)-4-(phenylthio)benzene manufacturers

Shenzhen Nexcon Pharmatechs Ltd.

Product: 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 2000
Release date: 2025-04-29

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-11

Henan Fengda Chemical Co., Ltd

Product: 1-(chloromethyl)-4-(phenylthio)benzene 1208-87-3
Price: US $101.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2023-12-28

1208-87-3, 1-(chloromethyl)-4-(phenylthio)benzene Related Search:

TIMTEC-BB SBB003011 4-(METHYLTHIO)BENZYL CHLORIDE 1-(chloromethyl)-4-(phenylthio)benzene

1-(chloromethyl)-4-(phenylthio)benzene

NSC 43056

1-(chloromethyl)-4-phenylsulfanylbenzene

(4-(Chloromethyl)phenyl)(phenyl)sulfane 2:CAS No: 10-25 gm

1-(Chloromethyl)-4-(phenylsulfanyl)

Benzene, 1-(chloromethyl)-4-(phenylthio)-

4-phenyl thio benzyl chloride (4-(chloromethyl)phenyl)(phenyl)sulfane

1208-87-3

C13H11ClS