ChemicalBook > CAS DataBase List > 4-(3-Chloro-phenyl)-thiazol-2-ylamine

4-(3-Chloro-phenyl)-thiazol-2-ylamine

Product Name
4-(3-Chloro-phenyl)-thiazol-2-ylamine
CAS No.
90533-23-6
Chemical Name
4-(3-Chloro-phenyl)-thiazol-2-ylamine
Synonyms
4-(3-Chlorophenyl)-2-thiazolamine;4-(3-Chlorophenyl)thiazol-2-amine;2-Thiazolamine, 4-(3-chlorophenyl)-;4-(3-chlorophenyl)thiazol-2(3H)-imine;1-(3-chloro-5-fluorophenyl)-3-buten-1-ol
CBNumber
CB3947331
Molecular Formula
C9H7ClN2S
Formula Weight
210.68
MOL File
90533-23-6.mol
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4-(3-Chloro-phenyl)-thiazol-2-ylamine Property

Melting point:
112 °C(Solv: ethanol (64-17-5))
Boiling point:
394.2±17.0 °C(Predicted)
Density 
1.389±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
3.94±0.10(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Matrix Scientific
Product number
199303
Product name
2-Amino-4-(3-chlorophenyl) thiazole
Packaging
1.00g
Price
$90
Updated
2026/05/18
Matrix Scientific
Product number
199303
Product name
2-Amino-4-(3-chlorophenyl) thiazole
Packaging
5.00g
Price
$266
Updated
2026/05/18
Matrix Scientific
Product number
199303
Product name
2-Amino-4-(3-chlorophenyl) thiazole
Packaging
25.00g
Price
$933
Updated
2026/05/18
Synthonix
Product number
C51091
Product name
4-(3-Chlorophenyl)thiazol-2-amine
Purity
95+%
Packaging
100mg
Price
$86
Updated
2026/05/06
Synthonix
Product number
C51091
Product name
4-(3-Chlorophenyl)thiazol-2-amine
Purity
95+%
Packaging
250mg
Price
$96
Updated
2026/05/06
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4-(3-Chloro-phenyl)-thiazol-2-ylamine Chemical Properties,Usage,Production

Synthesis

17356-08-0

99-02-5

90533-23-6

The reaction mixture was stirred at 100 °C for 8 hours with thiourea (50 mmol), 3-chloroacetophenone (25 mmol) and iodine (25 mmol). After completion of the reaction, the mixture was cooled and extracted with ether to remove unreacted 3-chloroacetophenone. Subsequently, it was washed with aqueous sodium thiosulfate to remove excess iodine and then with cold water. The crude product was dissolved in hot water and filtered to remove the sulfone by-product. The filtrate was alkalized with aqueous Na2CO3 to afford 2-amino-4-(3-chlorophenyl)-1,3-thiazole. Finally, the crude product was purified by recrystallization from alcohol.

References

[1] Chemical and Pharmaceutical Bulletin, 2007, vol. 55, # 7, p. 1014 - 1017
[2] European Journal of Medicinal Chemistry, 2013, vol. 66, p. 305 - 313
[3] Arzneimittel-Forschung/Drug Research, 1986, vol. 36, # 9, p. 1391 - 1393
[4] Bioorganic and Medicinal Chemistry, 2014, vol. 22, # 2, p. 692 - 702
[5] Bioorganic and Medicinal Chemistry Letters, 2014, vol. 24, # 23, p. 5428 - 5431

4-(3-Chloro-phenyl)-thiazol-2-ylamine Preparation Products And Raw materials

Raw materials

Preparation Products

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4-(3-Chloro-phenyl)-thiazol-2-ylamine Suppliers

Energy Chemical
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