NS1643

Product Name: NS1643
CAS No.: 448895-37-2
Chemical Name: NS1643
Synonyms: NS1643, >98%;NS1643 ，S5773;NS-1643;NS 1643;NS1643, 10 mM in DMSO;NS-1643;NS1643;NS 1643;1,3-bis(5-(trifluoromethyl)-2-hydroxyphenyl)urea;N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea;Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-;KcsA,NS1643,NS 1643,Potassium Channel,Inhibitor,inhibit,NS-1643,Autophagy
CBNumber: CB3972395
Molecular Formula: C15H10F6N2O3
Formula Weight: 380.24
MOL File: 448895-37-2.mol

More

Less

NS1643 Property

Boiling point:: 342.3±42.0 °C(Predicted)
Density: 1.626±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,2-8°C
solubility: DMSO: ≥20mg/mL
pka: 6.84±0.13(Predicted)
form: solid
color: white to off-white

More

Less

Safety

Hazard Codes: Xn
Risk Statements: 22-36
Safety Statements: 26
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N0663
Product name: NS1643
Purity: ≥98% (HPLC), solid
Packaging: 5mg
Price: $246.05
Updated: 2025/07/31

Sigma-Aldrich

Product number: N0663
Product name: NS1643
Purity: ≥98% (HPLC), solid
Packaging: 25mg
Price: $776
Updated: 2022/05/15

Cayman Chemical

Product number: 20343
Product name: NS 1643
Purity: ≥98%
Packaging: 5mg
Price: $44
Updated: 2024/03/01

Cayman Chemical

Product number: 20343
Product name: NS 1643
Purity: ≥98%
Packaging: 10mg
Price: $84
Updated: 2024/03/01

Cayman Chemical

Product number: 20343
Product name: NS 1643
Purity: ≥98%
Packaging: 25mg
Price: $172
Updated: 2024/03/01

More

Less

NS1643 Chemical Properties,Usage,Production

Uses

NS 1643 is a human ether-a-go-go-related gene 1 potassium channel (KCNH2) activator.

Biological Activity

Human ether-a-go-go related gene (hERG) K + channel activator (EC 50 = 10.5 μ M). Exhibits different molecular mechanisms of action at hERG1 and hERG2 channels. Displays antiarrhythmic activity in vitro .

in vivo

NS1643 (6 mg/kg; i.p., twice per week) inhibits breast tumor metastasis^[2].

Animal Model:	NSG mice with human-derived TNBC tumor xenografts^[2]
Dosage:	6 mg/kg
Administration:	Intraperitoneal injection; 6 mg/kg; twice per week
Result:	Significantly reduceed tumor growth and the metastatic liver tumors were significantly smaller than those in the control group. Decreased levels of human nuclear antigen (HNA).

storage

+4°C

NS1643 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

NS1643 Suppliers

Canada 1 China 72 India 1 Switzerland 1 United Kingdom 1 United States 14 Global 90

SIGMA-RBI

Tel: --
Fax: --
Country: Switzerland
ProdList: 6896
Advantage: 91

More

Less

View Lastest Price from NS1643 manufacturers

Career Henan Chemica Co

Product: NS1643 448895-37-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: MIn98%HPLC/LC
Supply Ability: 100KGS
Release date: 2020-10-29

448895-37-2, NS1643Related Search:

NS 3694 1,4-Diazabicyclo[3.2.2]non-4-yl[5-[3-(trifluoromethyl)phenyl]-2-furanyl]methanone hydrochloride Adenosine 5'-[γ-thio]triphosphate TetralithiuM Salt APAMIN PENITREM A PNU 37883 hydrochloride TRAM-34 5-HYDROXYDECANOIC ACID SODIUM SALT CLOFILIUM TOSYLATE Gabapentin-lactam PAXILLINE Glibenclamide Minoxidil PCO 400 NS-6180 NS 1619 NS 1738 NS1652

N,N'-Bis[2-hydroxy-5-(trifluoromethyl)phenyl]urea

NS-1643;NS 1643

NS1643, >98%

NS-1643;NS1643;NS 1643

Urea, N,N'-bis[2-hydroxy-5-(trifluoromethyl)phenyl]-

1,3-bis(5-(trifluoromethyl)-2-hydroxyphenyl)urea

KcsA,NS1643,NS 1643,Potassium Channel,Inhibitor,inhibit,NS-1643,Autophagy

NS1643, 10 mM in DMSO

NS1643 ，S5773

448895-37-2

C15H10F6N2O3