7-AZAINDOLE-4-CARBOXALDEHYDE
- Product Name
- 7-AZAINDOLE-4-CARBOXALDEHYDE
- CAS No.
- 728034-12-6
- Chemical Name
- 7-AZAINDOLE-4-CARBOXALDEHYDE
- Synonyms
- 7-azaindole-4-carbaldehyde;7-azainole-4-carboxaldehyde;7-Azaindole-4-carbaldehyd...;7-AZAINDOLE-4-CARBOXALDEHYDE;1H-Pyrrolo[2,3-b]pyridin-4-carbaldehyde;1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde;1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde;1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde (9CI);1H-Pyrrolo[2,3-b]pyridine-4-carboxaldehyde (9CI, ACI)
- CBNumber
- CB4100557
- Molecular Formula
- C8H6N2O
- Formula Weight
- 146.15
- MOL File
- 728034-12-6.mol
7-AZAINDOLE-4-CARBOXALDEHYDE Property
- Density
- 1.368±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 12.72±0.40(Predicted)
- form
- Solid
- color
- yellow
- InChI
- InChI=1S/C8H6N2O/c11-5-6-1-3-9-8-7(6)2-4-10-8/h1-5H,(H,9,10)
- InChIKey
- IEPOMBHPYZJZNR-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=C(C=O)C=CN=2
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
N-Bromosuccinimide Price
- Product number
- CVT00121
- Product name
- 7-Azaindole-4-carboxaldehyde
- Purity
- AldrichCPR
- Packaging
- 1 g
- Price
- $1030
- Updated
- 2025/07/31
- Product number
- P860260
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-4-carbaldehyde
- Packaging
- 50mg
- Price
- $110
- Updated
- 2021/12/16
- Product number
- 4H56-1-075
- Product name
- 7-Azaindole-4-carbaldehyde
- Packaging
- 250mg
- Price
- $240
- Updated
- 2021/12/16
- Product number
- 4H56-1-075
- Product name
- 7-Azaindole-4-carbaldehyde
- Packaging
- 1g
- Price
- $699
- Updated
- 2021/12/16
- Product number
- 112244
- Product name
- 7-Azaindole-4-carbaldehyde
- Packaging
- 1g
- Price
- $908
- Updated
- 2021/12/16
7-AZAINDOLE-4-CARBOXALDEHYDE Chemical Properties,Usage,Production
Uses
7-Azaindole-4-carboxaldehyde is used as a pharmaceutical intermediate.
Synthesis
344327-11-3
728034-12-6
General procedure for the synthesis of 7-azaindole-4-carboxaldehyde from 4-cyano-7-azaindole: Part 4: Preparation of 1H-pyrrolo[2,3-b]pyridine-4-carboxaldehyde: 1H-pyrrolo[2,3-b]pyridine-4-carbonitrile (200 mg, 1.4 mmol) was dissolved in tetrahydrofuran (7 mL) and cooled to -78°C under nitrogen protection. Diisobutylaluminum hydride (DIBAL-H, 1.0 M toluene solution, 3.07 mL, 3.07 mmol) was added slowly. The reaction mixture was stirred at -78 °C for 1 h. The temperature was gradually increased to 55 °C and stirring was continued for 2 h. The reaction mixture was then stirred at -78 °C for 1 h. Subsequently, DIBAL-H (1.4 mL, 1.4 mmol) was added supplementally and the mixture continued to stir at 55 °C for 2 hours. After completion of the reaction, the mixture was cooled to 5 °C, acidified with 2 M hydrochloric acid and stirred for 15 min. Next, the reaction mixture was neutralized with saturated aqueous sodium bicarbonate, the organic phase was extracted with dichloromethane (5 x 25 mL), the organic layers were combined and washed with brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to give 1H-pyrrolo[2,3-b]pyridine-4-carbaldehyde (107 mg, 52% yield). Mass spectrum (ES+): m/z 146 [MH+]. 1H NMR (DMSO-d6, 400 MHz): δ 7.22 (d, 1H, J = 3.6 Hz), 7.57 (d, 1H, J = 4.8 Hz), 7.67 (d, 1H, J = 2.4 Hz), 8.61 (d, 1H, J = 5.2 Hz), 10.42 (s, 1H) .
References
[1] Patent: US2004/186124, 2004, A1. Location in patent: Page/Page column 14
[2] Patent: US2005/154014, 2005, A1
7-AZAINDOLE-4-CARBOXALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 7-AZAINDOLE-4-CARBOXALDEHYDE manufacturers
- Product
- 7-Azaindole-4-Carboxaldehyde 728034-12-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 0.0001kg
- Purity
- 98%min
- Supply Ability
- 100kgs/month
- Release date
- 2022-05-10
- Product
- 7-AZAINDOLE-4-CARBOXALDEHYDE 728034-12-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11