1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
- Product Name
- 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
- CAS No.
- 754214-42-1
- Chemical Name
- 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID
- Synonyms
- 7-Azaindole-5-carboxylic ...;7-AZAINDOLE-5-CARBOXYLIC ACID;7-Azaindole-5-carboxylic acid 97%;1H-Pyrrolo[2,3-b]pyridin-5-carboxylic acid;4-(Di-n-propylsulfamoyl)benzeneboronic acid;1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-5-carbo×ylic acid
- CBNumber
- CB5774744
- Molecular Formula
- C8H6N2O2
- Formula Weight
- 162.15
- MOL File
- 754214-42-1.mol
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID Property
- storage temp.
- Sealed in dry,Room Temperature
- form
- solid
- Appearance
- White to light yellow Solid
- InChI
- InChI=1S/C8H6N2O2/c11-8(12)6-3-5-1-2-9-7(5)10-4-6/h1-4H,(H,9,10)(H,11,12)
- InChIKey
- SINFYKZXNIJIEU-UHFFFAOYSA-N
- SMILES
- C12NC=CC1=CC(C(O)=O)=CN=2
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
N-Bromosuccinimide Price
- Product number
- ADE000888
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $817
- Updated
- 2025/07/31
- Product number
- B530500
- Product name
- 1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid
- Packaging
- 2.5g
- Price
- $310
- Updated
- 2021/12/16
- Product number
- OR40241
- Product name
- 7-Azaindole-5-carboxylicacid
- Purity
- 97%
- Packaging
- 5g
- Price
- $259
- Updated
- 2021/12/16
- Product number
- 4H21-1-BX
- Product name
- 7-Azaindole-5-carboxylic acid
- Packaging
- 5G
- Price
- $285
- Updated
- 2021/12/16
- Product number
- CHM0013186
- Product name
- 7-AZAINDOLE-5-CARBOXYLIC ACID
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $733.43
- Updated
- 2021/12/16
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID Chemical Properties,Usage,Production
Chemical Properties
White solid
Uses
1H-Pyrrolo[2,3-b]pyridine-5-carboxylic acid is used in pharmaceutical synthesis and experimental research.
Synthesis
754214-41-0
754214-42-1
The general procedure for the synthesis of 7-azaindole-5-carboxylic acid from the compound (CAS: 754214-41-0) was as follows: the crude acid 10 was dissolved in dichloromethane (5 mL), and DDQ was added in batches until TLC analysis showed complete consumption of the starting material. The reaction mixture was concentrated to give a solid residue containing azaindole 11. The residue was dissolved in 5% HCl in methanol solution (5 mL) and stirred for 1.5 hours at room temperature. After completion of the reaction, the mixture was concentrated and diluted with chloroform and saturated saline. The mixture was alkalized to pH 11 with 50% NaOH solution and the organic layer was discarded. The aqueous layer was neutralized with 6 M HCl and extracted with ethyl acetate (4 times). The organic extracts were combined, dried with magnesium sulfate, filtered and concentrated. The residue was purified by preparative thin layer chromatography (PTLC) using dichloromethane: methanol = 9:1 as eluent to give 7-azaindole-5-carboxylic acid 12 (3.19 mg, 3% overall yield in three steps). The product was characterized by 1H NMR (400 MHz, CD3OD): δ 6.58 (d, J = 3.5 Hz, 1H), 7.42 (d, J = 3.5 Hz, 1H), 8.58 (d, J = 2.0 Hz, 1H), 8.85 (d, J = 1.7 Hz, 1H).
References
[1] Patent: WO2004/78757, 2004, A2. Location in patent: Page 53-55
1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID manufacturers
- Product
- 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 754214-42-1
- Price
- US $8.80/KG
- Min. Order
- 1KG
- Purity
- 97%-99%
- Supply Ability
- 100kg
- Release date
- 2019-08-05