1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

Product Name: 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
CAS No.: 156270-06-3
Chemical Name: 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
Synonyms: 7-azaindole-3-carboxylic ...;7-AZAINDOLE-3-CARBOXYLIC ACID;7-Azaindole-3-carboxylic acid 95%;Methyl 7-azaindole-3-carboxylic acid;Pyrrolo[2,3-b]pyridine-3-carboxylicacid;1H-Pyrrolo[2,3-B]Pyridine-3-CarboxylicAci;1H-pyrrolo[2,3-b]pyridine-3-carbo×ylic acid;1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 3-Carboxy-1H-pyrrolo[2,3-b]pyridine
CBNumber: CB2728988
Molecular Formula: C8H6N2O2
Formula Weight: 162.15
MOL File: 156270-06-3.mol

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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Property

Melting point:: 205-209 °C
Boiling point:: 425.3±45.0 °C(Predicted)
Density: 1.49±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: 0.52±0.20(Predicted)
Appearance: Off-white to light brown Solid
Water Solubility: Slightly soluble in water.
InChI: InChI=1S/C8H6N2O2/c11-8(12)6-4-10-7-5(6)2-1-3-9-7/h1-4H,(H,9,10)(H,11,12)
InChIKey: KYBIRFFGAIFLPM-UHFFFAOYSA-N
SMILES: C12NC=C(C(O)=O)C1=CC=CN=2

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Safety

Hazard Codes: Xn
Risk Statements: 22-36/37/38
Safety Statements: 26
WGK Germany: 3
HazardClass: IRRITANT
HS Code: 29339980

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC

Product number: B529778
Product name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicAcid
Packaging: 100mg
Price: $60
Updated: 2021/12/16

AK Scientific

Product number: X4656
Product name: 7-Azaindole-3-carboxylic acid
Packaging: 5g
Price: $61
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK384725
Product name: 7-Azaindole-3-carboxylic acid
Purity: 97%
Packaging: 1g
Price: $94
Updated: 2021/12/16

Matrix Scientific

Product number: 046628
Product name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid
Purity: >95%
Packaging: 5g
Price: $105
Updated: 2021/12/16

Oakwood

Product number: 066602
Product name: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid
Purity: 97%
Packaging: 250mg
Price: $25
Updated: 2021/12/16

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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

7-Azaindole-3-carboxylic acid is a reactant for synthesis of azaindol derivatives as new acrosin inhibitors and for preparation of triazoles via regioselective heterocyclizaiton reactions. It is also a reactant for synthesis of azaindolylcarboxy-endo-tropanamide.

Synthesis

1065100-83-5

156270-06-3

(1) (1H-pyrrolo[2,3-b]pyridin-3-yl)methanol was used as a raw material and reacted with formaldehyde under microwave radiation at a molar ratio of 1:1.2. In the reaction system, the concentration of 7-azaindole to water was 1 mol/L, the molar ratio of 7-azaindole to tetramethylguanidine was 2:5, and the mass ratio of 7-azaindole to MFI zeolites was 6:7. (2) The 7-azaindole obtained from step (1) was The 7-azaindole-3-methanol was dissolved in dichloromethane, heated to 50 °C, KMnO4 was added (the molar ratio of 7-azaindole-3-methanol to KMnO4 was 12:15) and mixed thoroughly. The reaction mixture was stirred for 3 hours, then filtered, the filtrate was evaporated under reduced pressure, and the resulting solid was purified by recrystallization to give 7-azaindole-3-carboxylic acid in 94.3% yield and 99.3% purity.

References

[1] Patent: CN107903261, 2018, A. Location in patent: Paragraph 0021-0031; 0035-0038; 0042-0045; 0049-0059

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Suppliers

China 158 Germany 2 India 4 Switzerland 1 United Kingdom 5 United States 17 Global 187

ITIC MEDCHEM(SUZHOU) CO.,LTD.

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid 156270-06-3
Price: US $2.20-8.80/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons
Release date: 2025-07-08

Henan Aochuang Chemical Co.,Ltd.

Product: 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid 156270-06-3
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-29

Career Henan Chemical Co

Product: 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 156270-06-3
Price: US $8.80/KG
Min. Order: 1KG
Purity: 97%-99%
Supply Ability: 100kg
Release date: 2019-08-05

156270-06-3, 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACIDRelated Search:

1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 4-bromo- 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID METHYL 7-AZAINDOLE-3-GLYOXYLATE 6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid,1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 6-chloro- 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 4-chloro- 5-(BENZYLOXY)-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID 1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-(methylthio)-, methyl ester 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid 5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE

7-AZAINDOLE-3-CARBOXYLIC ACID

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

Methyl 7-azaindole-3-carboxylic acid

7-azaindole-3-carboxylic ...

1H-pyrrolo[2,3-b]pyridine-3-carbo×ylic acid

7-Azaindole-3-carboxylic acid 95%

1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 3-Carboxy-1H-pyrrolo[2,3-b]pyridine

1H-Pyrrolo[2,3-B]Pyridine-3-CarboxylicAci

Pyrrolo[2,3-b]pyridine-3-carboxylicacid

156270-06-3

Carboxylic Acids

Fused Ring Systems

Azaindoles