ChemicalBook > CAS DataBase List > 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID

Product Name
1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
CAS No.
156270-06-3
Chemical Name
1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
Synonyms
7-azaindole-3-carboxylic ...;7-AZAINDOLE-3-CARBOXYLIC ACID;7-Azaindole-3-carboxylic acid 95%;Methyl 7-azaindole-3-carboxylic acid;Pyrrolo[2,3-b]pyridine-3-carboxylicacid;1H-Pyrrolo[2,3-B]Pyridine-3-CarboxylicAci;1H-pyrrolo[2,3-b]pyridine-3-carbo×ylic acid;1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID;1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 3-Carboxy-1H-pyrrolo[2,3-b]pyridine
CBNumber
CB2728988
Molecular Formula
C8H6N2O2
Formula Weight
162.15
MOL File
156270-06-3.mol
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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Property

Melting point:
205-209 °C
Boiling point:
425.3±45.0 °C(Predicted)
Density 
1.49±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
form 
solid
pka
0.52±0.20(Predicted)
Appearance
Off-white to light brown Solid
Water Solubility 
Slightly soluble in water.
InChI
InChI=1S/C8H6N2O2/c11-8(12)6-4-10-7-5(6)2-1-3-9-7/h1-4H,(H,9,10)(H,11,12)
InChIKey
KYBIRFFGAIFLPM-UHFFFAOYSA-N
SMILES
C12NC=C(C(O)=O)C1=CC=CN=2
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29339980
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TRC
Product number
B529778
Product name
1H-Pyrrolo[2,3-b]pyridine-3-carboxylicAcid
Packaging
100mg
Price
$60
Updated
2021/12/16
AK Scientific
Product number
X4656
Product name
7-Azaindole-3-carboxylic acid
Packaging
5g
Price
$61
Updated
2021/12/16
Frontier Specialty Chemicals
Product number
JK384725
Product name
7-Azaindole-3-carboxylic acid
Purity
97%
Packaging
1g
Price
$94
Updated
2021/12/16
Matrix Scientific
Product number
046628
Product name
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid
Purity
>95%
Packaging
5g
Price
$105
Updated
2021/12/16
Oakwood
Product number
066602
Product name
1H-Pyrrolo[2,3-b]pyridine-3-carboxylicacid
Purity
97%
Packaging
250mg
Price
$25
Updated
2021/12/16
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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Chemical Properties,Usage,Production

Chemical Properties

Solid

Uses

7-Azaindole-3-carboxylic acid is a reactant for synthesis of azaindol derivatives as new acrosin inhibitors and for preparation of triazoles via regioselective heterocyclizaiton reactions. It is also a reactant for synthesis of azaindolylcarboxy-endo-tropanamide.

Synthesis

1065100-83-5

156270-06-3

(1) (1H-pyrrolo[2,3-b]pyridin-3-yl)methanol was used as a raw material and reacted with formaldehyde under microwave radiation at a molar ratio of 1:1.2. In the reaction system, the concentration of 7-azaindole to water was 1 mol/L, the molar ratio of 7-azaindole to tetramethylguanidine was 2:5, and the mass ratio of 7-azaindole to MFI zeolites was 6:7. (2) The 7-azaindole obtained from step (1) was The 7-azaindole-3-methanol was dissolved in dichloromethane, heated to 50 °C, KMnO4 was added (the molar ratio of 7-azaindole-3-methanol to KMnO4 was 12:15) and mixed thoroughly. The reaction mixture was stirred for 3 hours, then filtered, the filtrate was evaporated under reduced pressure, and the resulting solid was purified by recrystallization to give 7-azaindole-3-carboxylic acid in 94.3% yield and 99.3% purity.

References

[1] Patent: CN107903261, 2018, A. Location in patent: Paragraph 0021-0031; 0035-0038; 0042-0045; 0049-0059

1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID Suppliers

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View Lastest Price from 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
1H-Pyrrolo[2,3-B]Pyridine-3-Carboxylic Acid 156270-06-3
Price
US $2.20-8.80/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons
Release date
2025-07-08
Henan Aochuang Chemical Co.,Ltd.
Product
1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid 156270-06-3
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-29
Career Henan Chemical Co
Product
1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID 156270-06-3
Price
US $8.80/KG
Min. Order
1KG
Purity
97%-99%
Supply Ability
100kg
Release date
2019-08-05

156270-06-3, 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACIDRelated Search:

1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 4-bromo- 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID METHYL 7-AZAINDOLE-3-GLYOXYLATE 6-chloro-1H-pyrrolo[2,3-b]pyridine-3-carboxylic acid,1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 6-chloro- 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 4-chloro- 5-(BENZYLOXY)-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 1H-PYRROLO[2,3-B]PYRIDINE-4-CARBOXYLIC ACID 1-Benzenesulfonyl-1H-pyrrolo[2,3-b]pyridine-5-carboxylic acid methyl ester 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 4-(methylthio)-, methyl ester 5-METHOXY-1H-PYRROLO[3,2-B]PYRIDINE-2-CARBOXYLIC ACID 1H-PYRROLO[2,3-B]PYRIDINE-6-CARBOXYLIC ACID 1H-Pyrrolo[2,3-b]pyridine-2-carboxylic acid, 3-amino-, ethyl ester 6-chloro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid 1H-PYRROLO[2,3-B]PYRIDINE-5-CARBOXYLIC ACID 6-chloro-1H-pyrrolo[3,2-c]pyridine-2-carboxylic acid 5-fluoro-1H-pyrrolo[2,3-b]pyridine-2-carboxylic acid ETHYL 4-METHOXY-1H-PYRROLO[2,3-B]PYRIDINE-2-CARBOXYLATE

  • 7-AZAINDOLE-3-CARBOXYLIC ACID
  • 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLIC ACID
  • Methyl 7-azaindole-3-carboxylic acid
  • 7-azaindole-3-carboxylic ...
  • 1H-pyrrolo[2,3-b]pyridine-3-carbo×ylic acid
  • 7-Azaindole-3-carboxylic acid 95%
  • 1H-Pyrrolo[2,3-b]pyridine-3-carboxylic acid, 3-Carboxy-1H-pyrrolo[2,3-b]pyridine
  • 1H-Pyrrolo[2,3-B]Pyridine-3-CarboxylicAci
  • Pyrrolo[2,3-b]pyridine-3-carboxylicacid
  • 156270-06-3
  • Carboxylic Acids
  • Fused Ring Systems
  • Azaindoles