(-)-ANABASINE

ChemicalBook > CAS DataBase List > (-)-ANABASINE

Product Name: (-)-ANABASINE
CAS No.: 13078-04-1
Chemical Name: (-)-ANABASINE
Synonyms: ANABASINE;NEONICOTINE;(-)-ANABASINE;(n)-anabasine;Anabasine >=97%;L(-)-NEONICOTINE;Anabasine, Neonicotine;2-(3-PYRIDYL)PIPERIDINE;Rizatriptan Impurity 25;(±)-Anabasine, tech. 85%
CBNumber: CB4100643
Molecular Formula: C10H14N2
Formula Weight: 162.23
MOL File: 13078-04-1.mol

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(-)-ANABASINE Property

Melting point:: 9 °C
Boiling point:: 270 °C
Density: 1.05 g/mL at 25 °C(lit.)
refractive index: 1.5440
Flash point:: 93 °C
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: H₂O: 10 mg/mL
pka: 8.98±0.10(Predicted)
form: liquid
color: colorless to yellow
Merck: 14,619
BRN: 82639
InChIKey: MTXSIJUGVMTTMU-UHFFFAOYSA-N
LogP: 0.852 (est)

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Safety

Hazard Codes: T,Xn
Risk Statements: 23/24/25-36/37/38-25-20/21/22-51/53-27/28
Safety Statements: 36/37/39-45-26-36-57-27/28-23-20
RIDADR: UN 3140 6.1/PG 2
WGK Germany: 3
RTECS: BV4375000
Hazard Note: Toxic
HazardClass: 6.1
PackingGroup: I
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 284599
Product name: Anabasine
Purity: ≥97%
Packaging: 100mg
Price: $150
Updated: 2023/06/20

Sigma-Aldrich

Product number: 284599
Product name: Anabasine
Purity: ≥97%
Packaging: 1g
Price: $704
Updated: 2023/06/20

Alfa Aesar

Product number: L12089
Product name: (±)-Anabasine
Purity: tech. 85%
Packaging: 1g
Price: $448
Updated: 2021/12/16

TRC

Product number: A637175
Product name: (R,S)-Anabasine
Packaging: 500mg
Price: $470
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PXT0005222
Product name: (R,S)-ANABASINE
Purity: 95.00%
Packaging: 5MG
Price: $505.55
Updated: 2021/12/16

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(-)-ANABASINE Chemical Properties,Usage,Production

Description

Anatabine is an alkaloid found in the root, fibrous roots, or bark of Alangium chinense (Lour) Harms. The herb was recorded in “Jianyi Bencao,” “Bencao Gangmu Shiyi,” and “Zhi Wu Ming Shi Tu Kao.” Alangium chinense is widely distributed in the east and south of China. It is also called “Bailongxu” in Shaanxi, Yunnan, and Guizhou provinces, “Baijintiao” in Guangxi province, and “Bajiaowutong,” “Bajiaojinpan,” or “Laolongxu” in Jiangxi and Hubei provinces. This plant is commonly used as a traditional Chinese medicine. The Alangium species includes more than 30 plants which are distributed in Asia, Oceania, and Africa. Nine of these plants are distributed in China. The root and the stem parts of Alangium plants are toxic.

Chemical Properties

Colourless Oil

Physical properties

Appearance: Colorless to yellow liquid. Solubility: Soluble in water and common organic solvents. Boiling point: 110?°C. Refractive index: 1.5418. Density: 1.0516?g cm?3.

History

Alangium chinense contains alkaloids, sugars, saponins, steroids, triterpenes, anthraquinones and their glycosides, and other ingredients. In 1974, dl-anabasine was isolated from the fibrous roots of Alangium chinense . Four isoquinoline alkaloids including two new alkaloids (?)-10-O-dimethyl-eugenol base and 10-O-dimethyl-eugenol base were isolated. P-amyrin acetate, triacontanol, and β-sitosterol were then found in its leaves . Seven glycosides were isolated from the water-soluble fraction of dried leaves of Alangium chinense, and eight glycosides were also isolated from the n-butanol soluble part . Three new lignincompounds including 2-O-(β-apio-furanosyl)-β-glucoside, E ferulic acid ester, and Z ferulic acid ester were extracted from Alangium chinense, and their structures were determined. Nakamoto et?al. extracted 7-O-acetylmaleic acid from Alangium chinense and determined the structure. There are also long-chain fatty acids and short-chain alkanes in Alangium chinense leaves. The volatile oil was then analyzed, and 59 components are identified by GC-MS.?The total alkaloid content in the Alangium chinense was found to be fibrous root > fine root > coarse root > branch wood > leaf.

Uses

Anabasine, a tobacco alkaloid, was used as a biomarker of active tobacco use.

Uses

insecticide

Uses

A nicotinic receptor agonist

Definition

ChEBI: A pyridine alkaloid that is pyridine substituted by a piperidin-2-yl group at position 3.

General Description

Anabasine inhibited androstenedione conversion to estrogen in a dose-dependent manner.

Pharmacology

Alangium plants have wide pharmacological effects including muscle relaxation, central inhibition, anticancer, antibacterial, and so on. The “Jisong-II” injection has presynaptic and postsynaptic effects on the neuromuscular junction, and it acts as noncompetitive muscular relaxant . In 1979, the respiratory suppression experiments showed that Alangium chinense is a central nervous system depressant . The extract of Alangium chinense significantly inhibits the growth of P388 lymphoblastic leukemia and Gardner lymphosarcoma in mice, but it has no effect on Gross virus-induced leukemia, Warner myelomonocytic leukemia, and B16 melanoma . Another study reported that the anabasine could excite respiratory similar to nicotine and lobeline. Anabasine also induces high blood pressure and bradycardia. The components in the Alangium chinense extract can bind to the M, 5-HT and dopamine receptors indicating that Alangium chinense affects the central nervous system.

Clinical Use

The Alangium chinense was used for treating rheumatoid arthritis.

(-)-ANABASINE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from (-)-ANABASINE manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd

Product: (-)-ANABASINE 13078-04-1
Price: US $25.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20ton
Release date: 2024-05-11

Hebei Shengyang Water Conservancy Engineering Co., Ltd.

Product: (-)-ANABASINE 13078-04-1
Price: US $18.00/kg
Min. Order: 1kg
Purity: 99.9
Supply Ability: 5000
Release date: 2024-05-11

Career Henan Chemical Co

Product: (-)-ANABASINE 13078-04-1
Price: US $1.00/kg
Min. Order: 1 mg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-25

13078-04-1, (-)-ANABASINERelated Search:

(-)-ANABASINE,ANABASINE,L(-)-ANABASINE,L-ANABASINE,S-(-)-Anabasine (-)-ANABASINE (R,S)-N-NITROSOANABASINE (5-Bromopicolinoyl)piperidine, (5-Bromopyridin-2-yl)(piperidin-1-yl)methanone 1-(5-Bromopyrimidin-2-yl)piperidine-3-carboxylic acid DL-ANABASINE Hydrochloride 1-(3-CHLOROPYRIDIN-2-YL)PIPERIDIN-4-AMINE (R,S)-ANABASINE,DL-ANABASINE,ANABASINE,ANABASINE, DL-,(+/-)-ANABASINE 1-PYRIDIN-4-YLPIPERIDINE 1-(2-Pyridinyl)-4-piperidinamine 1-(PYRIDIN-4-YL)-PIPERIDINE-4-CARBOXYLIC ACID N-[1-(3-CHLOROPYRIDIN-2-YL)PIPERIDIN-4-YL]ACETAMIDE 3-BROMO-5-(2-PIPERIDINYL)PYRIDINE N-(beta-Hydroxypropyl)anabasine (+)-Anabasine.HCl N-Methylanabasine 2-(3,4,5,6-Tetrahydro-2H-[2,3']bipyridinyl-1-yl)-ethanol ANABASINE HYDROCHLORIDE (3-(2-PIPERIDYL)PYRIDINE HYDROCHLORIDE),ANABASINE HYDROCHLORIDE

(±)-Anabasine, tech. 85%

3-(2-Piperidinyl)pyridine, Neonicotine

2-(3-Pyridyl)piperidine, Neonicotine

3-piperidin-2-ylpyridine hydrochloride

(±)-Anabasine,3-(2-Piperidinyl)pyridine, Neonicotine

Anabasine,2-(3-Pyridyl)piperidine, Neonicotine

Anabasine, Neonicotine, 2-(Pyridin-3-yl)piperidine

Nicotine EP Impurity G (Anabasine )

Anabasine >=97%

3-(2-piperidyl)pyridine hydrochloride

(S)-1,2,3,4,5,6-HEXAHYDRO-[2,3']BIPYRIDINYL

(S)-(-)-2-(3-PYRIDYL)PIPERIDINE

NEONICOTINE

(R,S)-1,2,3,4,5,6-Hexahydro-[2,3’]bipyridinyl

1,2,3,4,5,6-hexahydro-2,3’-bipyridine

L(-)-NEONICOTINE

(-)-ANABASINE

ANABASINE

2-(3-PYRIDYL)PIPERIDINE

Neonicotine~2-(3-Pyridyl)piperidine

Anabasine, Neonicotine

(n)-anabasine

Pyridine, 3-(2-piperidinyl)-

(±)-AnabasineQ: What is (±)-Anabasine Q: What is the CAS Number of (±)-Anabasine Q: What is the storage condition of (±)-Anabasine Q: What are the applications of (±)-Anabasine

Endogenous Metabolite,(±) Anabasine,inhibit,Inhibitor

Nicotine EP Impurity G as Racemate

Nicotine Impurity G as Racemate

ANABASINE, DL-NEONICOTINE)

Rizatriptan Impurity 25

3-[(2RS)-Piperidin-2-yl]pyridine ((RS)-Anabasine)

13078-04-1

Aromatics Compounds

Alkaloids

Pyrans, Piperidines &Piperazines

Neuroscience

Neurotransmission

Neurotransmitters

Pesticides &amp

Pesticides Standards

Pyridines

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Nicotinic Acetylcholine Receptor Modulators

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Pyrans, Piperidines & Piperazines

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