ChemicalBook > CAS DataBase List > 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE

3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE

Product Name: 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
CAS No.: 1666-04-2
Chemical Name: 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE
Synonyms: 3,6-Dimethylsalicylaldehyde;3,6-Dimethylsalicylaldehyde>3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE;Benzaldehyde, 2-hydroxy-3,6-dimethyl-;3,6-Dimethyl-2-formylphenol, 2-Formyl-3-hydroxy-p-xylene, 3,6-Dimethylsalicylaldehyde
CBNumber: CB41010273
Molecular Formula: C9H10O2
Formula Weight: 150.17
MOL File: 1666-04-2.mol

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3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Property

Melting point:: 59.0 to 63.0 °C
Boiling point:: 230.1±35.0 °C(Predicted)
Density: 1.136±0.06 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: soluble in Methanol
form: powder to crystal
pka: 8.63±0.15(Predicted)
color: White to Light yellow to Light orange

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Safety

HS Code: 2912490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

TCI Chemical

Product number: D4507
Product name: 3,6-Dimethylsalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $180
Updated: 2025/07/31

TCI Chemical

Product number: D4507
Product name: 3,6-Dimethylsalicylaldehyde
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $599
Updated: 2025/07/31

TRC

Product number: H824985
Product name: 2-Hydroxy-3,6-dimethylbenzaldehyde
Packaging: 100mg
Price: $45
Updated: 2021/12/16

TRC

Product number: H824985
Product name: 2-Hydroxy-3,6-dimethylbenzaldehyde
Packaging: 250mg
Price: $70
Updated: 2021/12/16

TRC

Product number: H824985
Product name: 2-Hydroxy-3,6-dimethylbenzaldehyde
Packaging: 500mg
Price: $105
Updated: 2021/12/16

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3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Chemical Properties,Usage,Production

Uses

2-Hydroxy-3,6-dimethylbenzaldehyde

Synthesis

95-87-4

50-00-0

1666-04-2

To a solution of 2,5-dimethylphenol (7.0 g, 57.3 mmol) in acetonitrile (250 mL) was sequentially added triethylamine (30.1 mL, 0.212 mol) and magnesium chloride (8.17 g, 86 mmol). The reaction mixture was stirred at room temperature for 15 minutes before adding paraformaldehyde (11.5 g, 0.38 mol). Subsequently, the mixture was heated to 80 °C and kept for 20 hours. After completion of the reaction, acetonitrile was removed by distillation under reduced pressure. A 10% hydrochloric acid solution was added to the residue and stirred for 30 min at room temperature. The mixture was extracted with dichloromethane (2 x 40 mL), the organic layers were combined and dried over anhydrous sodium sulfate. The organic phase was concentrated under reduced pressure and the resulting crude product was purified by fast column chromatography on silica gel (eluent: dichloromethane) to afford the target product 3,6-dimethyl-2-hydroxybenzaldehyde (27a) (3.56 g, 23.7 mmol, 42% yield). The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 2.21 (s, 3H), 2.57 (s, 3H), 6.62 (d, J = 8.0 Hz, 1H), 7.24 (d, J = 8.0 Hz, 1H), 10.30 (s, 1H), 12.18 (s, 1H).

References

[1] Journal of Organometallic Chemistry, 2005, vol. 690, # 23, p. 5125 - 5144
[2] Journal of the Chemical Society, Perkin Transactions 2, 2001, # 9, p. 1573 - 1584
[3] Patent: WO2012/140243, 2012, A1. Location in patent: Page/Page column 137-138
[4] Journal of Organic Chemistry, 2013, vol. 78, # 14, p. 6890 - 6910
[5] Patent: US2016/152543, 2016, A1. Location in patent: Paragraph 1197; 1198; 1199

3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE manufacturers

Hefei Lbao Physical & Chemical Science Co.,Ltd

Product: 2-Hydroxy-3,6-dimethylbenzaldehyde 1666-04-2
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: Customise
Release date: 2025-10-23

Career Henan Chemical Co

Product: 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE 1666-04-2
Price: US $3.00/KG
Min. Order: 1KG
Purity: 98%min
Supply Ability: 200KG
Release date: 2020-01-07

1666-04-2, 3,6-DIMETHYL-2-HYDROXY BENZALDEHYDERelated Search:

FUMARPROTOCETRARIC ACID 2-HYDROXY-3-ISOPROPYL-6-METHYLBENZOIC ACID LASALOCID A SODIUM SALT Mycophenolic acid ATRANORIN 2-HYDROXY-6-ISOPROPYL-3-METHYLBENZOIC ACID PSOROMIC ACID OCHRATOXIN A Adriamycin TOLUALDEHYDES ISLANDICIN STICTIC ACID CYNODONTIN 3-tert-butyl-2-hydroxy-6-methylbenzoic acid CATENARIN 1,4-DIHYDROXY-2,3-DIMETHYLANTHRAQUINONE AMMONIUM CARMINATE VINEOMYCINE A1

3,6-DIMETHYL-2-HYDROXY BENZALDEHYDE

3,6-Dimethyl-2-formylphenol, 2-Formyl-3-hydroxy-p-xylene, 3,6-Dimethylsalicylaldehyde

3,6-Dimethylsalicylaldehyde

3,6-Dimethylsalicylaldehyde&gt

Benzaldehyde, 2-hydroxy-3,6-dimethyl-

1666-04-2